Anti cancer activity on graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leads

Current Topics in Medicinal Chemistry

Volumn 13, Issue 14, 2013, Pages 1666-1673

  Paul, Jeno ^a   Gnanam, R ^a   Jayadeepa, R M ^a   Arul, L ^a  

^a TAMIL NADU AGRICULTURAL UNIVERSITY   (India)

Author keywords

Acetogenins; Annonamine; AutoDock vina; Graviola; HeLa cell line; Kaempferol; PC3 cell line; R programming

Indexed keywords

ACETOGENIN; ANNONA MURICATA EXTRACT; ANONAINE; ASIMILOBINE; FRIEDELIN; KAEMPFEROL; LIGAND; PLANT EXTRACT; QUERCETIN; XYLOPINE;

ANNONA MURICATA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; EXTRACTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; PHYTOCHEMISTRY; PROTEIN ANALYSIS; TOXICITY TESTING;

ANNONA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; HELA CELLS; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PLANT EXTRACTS;

EID: 84887932620     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/15680266113139990117     Document Type: Article

References (26)

1. Li J. W. H. and Vederas J. C., Drug discovery and natural products: end of an era or an endless frontier. Science, 2009, 325, 161-165.
2. N. A. S. Lost., Crops of the Incas: Little-Known Plants of the Andes with Promise for Worldwide Cultivation. Ad Hoc Panel of the Advisory Committee on Technology Innovation, Board on Science and Technology for International Development, National Research Council. Washington, DC: The National Academies Press. 1989.
3. Abraham Z., Glimpses of Indian Ethno botany. Oxford and Publishing Co, New Delhi. 1981, 308-320.
4. Cassileth, Barrie., Integrative Oncology: Complementary Therapies, Herbs, and Other OTC Agents. Oncology, September 2008.
5. Nicholas H. Oberlies., The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Cancer Letters, 1997, 115, 73-79.
6. Q. Ye.; K. He, N.; H. Oberlies et al., Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins. Journal of Medicinal Chemistry, 1996, vol. 39, no. 9, pp. 1790-1796.
7. Alali F. Q. et al., Annonaceous acetogenins: recent progress. J. Nat. Prod., 1999, Mar; 62 (3), 504-40.
8. McLaughlin, J. L. et al., Paw paw and cancer: annonaceous acetogenins from discovery to commercial products. J. Nat. Prod., 2008, Jul; 71 (7), 1311-21, doi: 10. 1021/np800191t. Epub 2008 Jul4.
9. Li, Z.; Xu, M.; Xing, S.; Ho, W. T.; Ishii, T.; Li, Q.; Fu, X.; Zhao, Z. J., Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J. Biol. Chem., 2007, Feb 9, 282 (6), 3428-32. Epub 2006 Dec 18.
10. Steiner, A. Z.; Terplan, M.; Paulson, R. J., Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis. Hum. Reprod, 2005 Jun; 20 (6), 1511-5. Epub 2005 Apr 21.
11. Klareskog, L.; van der Heijde, D.; de Jager, J. P.; Gough, A.; Kalden, J.; Malaise, M.; Martin Mola E.; Pavelka, K.; Sany, J.; Settas, L.; Wajdula, J.; Pedersen, R.; Fatenejad, S.; Sanda, M., Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004, Feb 28, 363 (9410), 675-681.
12. Nadiminty, N.; Tummala, R.; Liu, C.; Yang, J.; Lou, W.; Evans, C. P.; Gao, A. C., NF-kappaB2/p52 induces resistance to Enzalutamide in Prostate Cancer: Role of the androgen receptor and its variants. Mol. Cancer Ther., 2013, May 22.
13. Von Der Maase, H.; Hansen, S. W.; Roberts, J. T.; Dogliotti, L.; Oliver, T.; Moore, M. J.; Bodrogi, I.; Albers, P., et al., Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol., 2000, 18 (17): 3068.
14. st edn. Vol I, 2007, 232-255.
15. Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. " Adv. Drug Deliv. Rev., March 2001, 46 (1-3): 3-26. doi: 10. 1016/S0169-409X(00)00129-0.
16. http://www. chemaxon. com/products/marvin/.
17. Bamborough & Cohen, Modeling protein-ligand complexes. Curr. Opin. Struct. 1996, Biol., 6, 236-241.
18. Trott, O.; Olson, A. J., AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. Journal of Computational Chemistry, 2010, 31, 455-461.
19. Laurie, A. T.; Jackson, R. M., Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites. Bioinformatics, 2005, 21, 1908-1916.
20. Peter J. A. Cock, Tiago Antao, Jeffrey T. Chang, Brad A. Chapman, Cymon J. Cox, Andrew Dalke, Iddo Friedberg, Thomas Hamelryck, Frank Kauff, Bartek Wilczynski, Michiel J. L. de Hoon: "Biopython: freely available Python tools for computational molecular biology and Bioinformatics. " Bioinformatics, 2009, 25 (11), 1422-1423. doi: 10. 1093/bioinformatics/btp163.
21. Ribeiro de Souza, E. B.; da Silva R. R.; Afonso, S.; and Scarminio, I. S., Enhanced extraction yields and mobile phase separations by solvent mixtures for the analysis of metabolites in Annona muricata L. leaves. J. Sep. Sci., 2009. 32(23-24), 4176-4185.
22. http://www. opentox. org/.
23. Székely, G. J.; and Rizzo, M. L., Hierarchical clustering via Joint Between-Within Distances: Extending Ward's Minimum Variance Method. Journal of Classification, 2005, 22, 151-183.
24. Ward, Joe H., Hierarchical Grouping to Optimize an Objective Function. " Journal of the American Statistical Association, 1963, 58 (301), 236-244. doi: 10. 2307/2282967. JSTOR 2282967. MR 0148188.
25. Torres, M. P.; Rachagani, S.; Purohit, V.; Pandey, P.; Joshi, S.; Moore, E. D.; Johansson, S. L.; Singh, P. K.; Ganti, A. K.; and Batra, S. K., Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Lett., 2012, 323(1), 29-40.
26. Hamizah, S. A. H.; Roslida, O.; Fezah, K. L.; Tan, Y. S.; Tor and C. I. Tan., Chemopreventive Potential of Annona muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice. Asian Pacific Journal of Cancer Prevention, 2012, 13(6), 2533-2539.