Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E

Biochemistry

Volumn 42, Issue 20, 2003, Pages 6234-6240

  Hooker, Lisa ^a,c   Sully, R Rachel ^a,c   Handa, Balraj ^a,d   Ono, Naomi ^b   Koyano, Hiroshi ^b   Klumpp, Klaus ^a,e  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b NIPPON ROCHE RESEARCH CENTER   (Japan)

^c OSI Pharmaceuticals   (United Kingdom)

^d Argenta Discovery Ltd   (United Kingdom)

^e ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; CROSSLINKING; ENZYME INHIBITION; MOLECULAR STRUCTURE; RNA; ULTRAVIOLET RADIATION;

CAP BINDING;

VIRUSES;

7 METHYLGUANOSINE; CAPPED RNA; ENDONUCLEASE; GUANOSINE TRIPHOSPHATE DERIVATIVE; MESSENGER RNA PRECURSOR; NUCLEOTIDE; OLIGONUCLEOTIDE; PHOSPHATE; PROTEIN EIF4E; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BINDING SITE; CELL NUCLEUS; CONTROLLED STUDY; CROSS LINKING; ENERGY; ENZYME SUBUNIT; HUMAN; INFLUENZA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; RNA CLEAVAGE; TRANSCRIPTION INITIATION; ULTRAVIOLET IRRADIATION;

BASE SEQUENCE; CROSS-LINKING REAGENTS; ENDONUCLEASES; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; INFLUENZA A VIRUS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RNA CAP ANALOGS; RNA CAP-BINDING PROTEINS; RNA CAPS; ULTRAVIOLET RAYS; VIRAL PROTEINS; VIRUS REPLICATION;

HUMAN INFLUENZA VIRUS; INFLUENZA VIRUS; RNA VIRUSES;

EID: 0038182864     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027081r     Document Type: Article

References (23)

1. Lamb, R. A., and Krug, R. M. (2001) Orthomyxoviridae: The Viruses and Their Replication, in Fields Virology (Knipe, D. M., Howley, P. M., Eds.) Vol. 1, pp 1487-1532, Lippincott Williams & Wilkins, Philadelphia.
2. Tomassini, J., Selnick, H., Davies, M. E., Armstrong, M. E., Baldwin, J., Bourgeois, M., Hastings, J., Hazuda, D., Lewis, J., McClements, W., Ponticello, G., Radzilowski, E., Smith, G., Tebben, A., and Wolfe, A. (1994) Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob. Agents Chemother. 38, 2827-2837.
3. Tisdale, M., Ellis, M., Klumpp, K., Court, S., and Ford, M. (1995) Inhibition of Influenza virus transcription by 2′-Deoxy-2′-Fluoroguanosine. Antimicrob. Agents Chemother. 39, 2454-2458.
4. Blaas, D., Patzelt, E., and Kuechler, E. (1982) Identification of the cap binding protein of influenza virus. Nucleic Acids Res. 10, 4803-12.
5. Ulmanen, I., Broni, B. A., and Krug, R. M. (1981) Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proc. Natl. Acad. Sci. U.S.A. 78, 7355-7359.
6. Honda, A., Mizumoto, K., and Ishihama, A. (1999) Two separate sequences of PB2 subunit constitute the cap binding site of influenza virus RNA polymerase. Genes Cells 4, 475-485.
7. Li, M. L., Rao, P., and Krug, R. M. (2001) The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J. 20, 2078-2086.
8. Biswas, S. K., and Nayak, D. P. (1994) Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1. J. Virol. 68, 1819-1826.
9. Braam, J., Ulmanen, I., and Krug, R. M. (1983) Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription. Cell 34, 609-618.
10. Marcotrigiano, J., Gingras, A. C., Sonenberg, N., and Burley, S. K. (1997) Cocrystal structure of the messenger RNA 5′ capbinding protein (eIF4E) bound to 7-methyl-GDP. Cell 89, 951-961.
11. Matsuo, H., Li, H., McGuire, A. M., Fletcher, C. M., Gingras, A. C., Sonenberg, N., and Wagner, G. (1997) Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat. Struct. Biol. 4, 717-724.
12. Hodel, A. E., Gershon, P. D., Shi, X., Wang, S. M., and Quiocho, F. A. (1997) Specific protein recognition of an mRNA cap through its alkylated base. Nat. Struct. Biol. 4, 350-354.
13. Hodel, A. E., Gershon, P. D., Quiocho, F. A., and Lockless, S. W. (1998) Structural basis for sequence-nonspecific recognition of 5′-capped mRNA by a cap-modifying enzyme: Recognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2′-O-methyltransferase. Mol. Cell 1, 443-447.
14. de la Luna, S., Martinez, C., and Ortin, J. (1989) Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains. Virus Res. 13, 143-155.
15. Klumpp, K., Hooker, L., and Handa, B. (2001) Influenza virus endoribonuclease. Methods Enzymol. 342, 451-466.
16. Izawa, K., Shiragami, H., and Yamashita, K. (1996) Process for producing 9-substituted purines. Eur. Pat. Appl. CODEN: EPXXDW EP 728757 A1 19960828 CAN 125:247846 AN 1996: 612722.
17. Goss, D. J., Woodley, C. L., and Wahba, A. J. (1987) A fluorescence study of the binding of eucaryotic initiation factors to messenger RNA and messenger RNA analogues. Biochemistry 26, 1551-1556.
18. Minich, W. B., Balasta, M. L., Goss, D. J., and Rhoads, R. E. (1994) Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF4E: Increased cap affinity of the phosphorylated form. Proc. Natl. Acad. Sci. U.S.A. 91, 7668-7672.
19. Niedzwiecka, A., Marcotrigiano, J., Stepinski, J., Jankowska-Anyszka, M., Wyslouch-Cieszynska, A., Dadlez, M., Gingras, A. C., Mak, P., Darzynkiewicz, E., Sonenberg, N., Burley, S. K., and Stolarski, R. (2002) Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5′ cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J. Mol. Biol. 319, 615-635.
20. von der Haar, T., Ball, P. D., and McCarthy, J. E. G. (2000) Stabilisation of eukaryotic initiation factor 4E binding to the mRNA 5′-cap by domains of eIF4G. J. Biol. Chem. 275, 30551-30555.
21. Carberry, S. E., Darzynkiewicz, E., Stepinski, J., Tahara, S. T., Rhoads, R. E., and Goss, D. J. (1990) A spectroscopic study of the binding of N-7 substituted cap analogues to human protein synthesis initiation factor 4E. Biochemistry 29, 3337-3341.
22. Hu, G., Gershon, P. D., Hodel, A. E., and Quiocho, F. A. (1999) mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains. Proc. Natl. Acad. Sci. U.S.A. 96, 7149-7145.
23. Cai, A., Jankowska-Anyszka, M., Centers, A., Chlebicka, L., Stepinski, J., Stolarski, R., Darzynkiewicz, E., and Rhoads, R. (1999) Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation. Biochemistry 38, 8538-8547.