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Volumn 13, Issue 18, 2013, Pages 2386-2394

Repurposed drugs in metabolic disorders

Author keywords

Drug development; Metabolic disorders; Metabolism; New indication; Reprofiling; Repurposing; Retasking

Indexed keywords

4 PHENYLBUTYRIC ACID; AMITRIPTYLINE; APOMORPHINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CICLETANINE; COLESEVELAM; DAPROPTERIN; DASATINIB; DULOXETINE; FLUOXETINE; GLIZONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; LADOSTIGIL; LITHIUM; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MILNACIPRAN; MONOAMINE OXIDASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; NORTRIPTYLINE; OLANZAPINE; PIOGLITAZONE; PIOZ; PRAMIPEXOLE; QUETIAPINE; SAPROPTERIN; TETRACYCLINE DERIVATIVE; TETRAHYDROBIOPTERIN; UBIDECARENONE; UBIQUINONE; UNCLASSIFIED DRUG;

EID: 84887901946     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/15680266113136660166     Document Type: Article
Times cited : (18)

References (71)
  • 1
    • 79960830371 scopus 로고    scopus 로고
    • Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases
    • Xu, K.; Coté, T. R. Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. Brief. Bioinform, 2011, 12, 341-345.
    • (2011) Brief. Bioinform , vol.12 , pp. 341-345
    • Xu, K.1    Coté, T.R.2
  • 3
    • 77954813961 scopus 로고    scopus 로고
    • Repurposing Strategies for Therapeutics
    • Sleigh, S. H.; Barton, C. L. "Repurposing Strategies for Therapeutics. " Pharm. Med, 2010, 24, 151-159.
    • (2010) Pharm. Med , vol.24 , pp. 151-159
    • Sleigh, S.H.1    Barton, C.L.2
  • 4
    • 0034176921 scopus 로고    scopus 로고
    • Tetrahydrobiopterin biosynthesis, regeneration and functions
    • Thöny, B.; Auerbach, G.; Blau, N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem. J, 2000, 347, 1-16.
    • (2000) Biochem. J , vol.347 , pp. 1-16
    • Thöny, B.1    Auerbach, G.2    Blau, N.3
  • 5
    • 84887929984 scopus 로고    scopus 로고
    • (access May 2012), FOLIA HISTOCHEMICA ET CYTOBIOLOGICA 2005 Department of Functional Morphology, Division of Animal Anatomy, University of Warmia and Mazury, Olsztyn, Poland; page 4]
    • Cáka, J. The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA 2005 Department of Functional Morphology, Division of Animal Anatomy, University of Warmia and Mazury, Olsztyn, Poland; 2005; page 4] http://fhc. amb. edu. pl/archives/fulltxt/vol44/44-1/03-12. pdf, (access May 2012).
    • (2005) The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons
    • Cáka, J.1
  • 6
    • 84875243923 scopus 로고    scopus 로고
    • Dopa-Responsive Dystonia Revisited: Diagnostic Delay, Residual Signs, and Nonmotor Signs
    • Tadic, V.; Kasten, M.; Brüggemann, N.; Stiller, S.; Hagenah, J.; Klein, C. Dopa-Responsive Dystonia Revisited: Diagnostic Delay, Residual Signs, and Nonmotor Signs. Arch. Neurol, 2012, 17, 1-5.
    • (2012) Arch. Neurol , vol.17 , pp. 1-5
    • Tadic, V.1    Kasten, M.2    Brüggemann, N.3    Stiller, S.4    Hagenah, J.5    Klein, C.6
  • 7
    • 65549115456 scopus 로고    scopus 로고
    • Nitric oxide and vascular insulin resistance
    • Wu, G.; Meininger, C. J. Nitric oxide and vascular insulin resistance. Biofactors, 2009, 35, 21-27.
    • (2009) Biofactors , vol.35 , pp. 21-27
    • Wu, G.1    Meininger, C.J.2
  • 8
    • 13444262357 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Regulator of endothelial nitric oxide synthase in vascular disease
    • Channon, K. M. Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc. Med, 2004, 14, 823-827.
    • (2004) Trends Cardiovasc. Med , vol.14 , pp. 823-827
    • Channon, K.M.1
  • 9
    • 85047690420 scopus 로고    scopus 로고
    • Tetrahydrobiopterindependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
    • Alp, N. J.; Mussa, S.; Khoo, J.; Cai, S.; Guzik, T.; Jefferson, A.; Goh, N.; Rockett, K. A.; Channon, K. M. Tetrahydrobiopterindependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J. Clin. Invest, 2003, 112, 725-735.
    • (2003) J. Clin. Invest , vol.112 , pp. 725-735
    • Alp, N.J.1    Mussa, S.2    Khoo, J.3    Cai, S.4    Guzik, T.5    Jefferson, A.6    Goh, N.7    Rockett, K.A.8    Channon, K.M.9
  • 13
    • 84863393087 scopus 로고    scopus 로고
    • Evolving patient selection and clinical benefit criteria for sapropterin dihydrochloride (Kuvan®) treatment of PKU patients
    • Gordon, P.; Thomas, J. A.; Suter, R.; Jurecki, E. Evolving patient selection and clinical benefit criteria for sapropterin dihydrochloride (Kuvan®) treatment of PKU patients. Mol. Genet. Metab, 2012, 105, 672-676.
    • (2012) Mol. Genet. Metab , vol.105 , pp. 672-676
    • Gordon, P.1    Thomas, J.A.2    Suter, R.3    Jurecki, E.4
  • 15
    • 39049099124 scopus 로고    scopus 로고
    • Sapropterin dihydrochloride, 6-R-L-erythro 5, 6, 7, 8-tetrahydrobiopterin, in the treatment of phenylketonuria
    • Michals-Matalon, K. Sapropterin dihydrochloride, 6-R-L-erythro 5, 6, 7, 8-tetrahydrobiopterin, in the treatment of phenylketonuria. Expert Opin. Investig. Drugs, 2008, 17, 245-251.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 245-251
    • Michals-Matalon, K.1
  • 16
    • 84887944983 scopus 로고    scopus 로고
    • In: Pharmazeutische Zeitung Online 15, (access May 2012)
    • Wick-Urban, B. Trotz Ketonurie normal essen. In: Pharmazeutische Zeitung Online 15, 2007, (access May 2012).
    • (2007) Trotz Ketonurie normal essen
    • Wick-Urban, B.1
  • 17
    • 84887867727 scopus 로고    scopus 로고
    • Merck Serono erhält Zulassungsempfehlung für Kuvan(R) in Europa, September
    • Merck Serono erhält Zulassungsempfehlung für Kuvan(R) in Europa. Pressemitteilung von Merck Serono, vom 26. September 2008.
    • (2008) Pressemitteilung von Merck Serono, vom 26
  • 18
    • 77954946690 scopus 로고    scopus 로고
    • Tetrahydrobiopterin as a novel therapeutic intervention for autism
    • Frye, R. E.; Huffman, L. C.; Elliott, G. R. Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics, 2010, 7, 241-249.
    • (2010) Neurotherapeutics , vol.7 , pp. 241-249
    • Frye, R.E.1    Huffman, L.C.2    Elliott, G.R.3
  • 19
    • 79960803194 scopus 로고    scopus 로고
    • Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin
    • Moens, A. L.; Kietadisorn, R.; Lin, J. Y.; Kass, D. Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin. J. Mol. Cell. Cardiol, 2011, 51, 559-563.
    • (2011) J. Mol. Cell. Cardiol , vol.51 , pp. 559-563
    • Moens, A.L.1    Kietadisorn, R.2    Lin, J.Y.3    Kass, D.4
  • 20
    • 0035667921 scopus 로고    scopus 로고
    • Biochemical functions of coenzyme Q10
    • Crane, F. L. Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr, 2001, 20, 591-598.
    • (2001) J. Am. Coll. Nutr , vol.20 , pp. 591-598
    • Crane, F.L.1
  • 22
    • 0029042393 scopus 로고
    • Biochemical, physiological and medical aspects of ubiquinone function
    • Ernster, L.; Dallner, G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta, 1995, 1271, 195-204.
    • (1995) Biochim. Biophys. Acta , vol.1271 , pp. 195-204
    • Ernster, L.1    Dallner, G.2
  • 23
    • 33645099245 scopus 로고    scopus 로고
    • Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
    • Bhagavan, H. N.; Chopra, R. K. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res, 2006, 40, 445-453.
    • (2006) Free Radic. Res , vol.40 , pp. 445-453
    • Bhagavan, H.N.1    Chopra, R.K.2
  • 24
    • 84859436493 scopus 로고    scopus 로고
    • CoQ(10) deficiencies and MNGIE: Two treatable mitochondrial disorders
    • Hirano, M.; Garone, C.; Quinzii, C. M. CoQ(10) deficiencies and MNGIE: Two treatable mitochondrial disorders. Biochim. Biophys. Acta, 2012, 1820, 625-631.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 625-631
    • Hirano, M.1    Garone, C.2    Quinzii, C.M.3
  • 25
    • 80054861726 scopus 로고    scopus 로고
    • Primary and secondary CoQ(10) deficiencies in humans
    • Quinzii, C. M.; Hirano, M. Primary and secondary CoQ(10) deficiencies in humans. Biofactors, 2011, 37, 361-365.
    • (2011) Biofactors , vol.37 , pp. 361-365
    • Quinzii, C.M.1    Hirano, M.2
  • 27
    • 34248215663 scopus 로고    scopus 로고
    • CoQ10 deficiency diseases in adults
    • Quinzii, C. M.; Hirano, M.; DiMauro, S. CoQ10 deficiency diseases in adults. Mitochondrion, 2007, 7(suppl), S122-S126.
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL.
    • Quinzii, C.M.1    Hirano, M.2    DiMauro, S.3
  • 29
    • 0034822296 scopus 로고    scopus 로고
    • Neonatal presentation of coenzyme Q10 deficiency
    • Rahman, S.; Hargreaves, I.; Clayton, P.; Heales, S. Neonatal presentation of coenzyme Q10 deficiency. J. Pediatr, 2001, 139, 456-458.
    • (2001) J. Pediatr , vol.139 , pp. 456-458
    • Rahman, S.1    Hargreaves, I.2    Clayton, P.3    Heales, S.4
  • 30
    • 84863874490 scopus 로고    scopus 로고
    • Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ(10)
    • Horvath, R. Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ(10). J. Inherit. Metab. Dis, 2012, 35, 679-687.
    • (2012) J. Inherit. Metab. Dis , vol.35 , pp. 679-687
    • Horvath, R.1
  • 32
    • 57149086339 scopus 로고    scopus 로고
    • Decreased ubiquinone availability and impaired mitochondrial cytochrome oxidase activity associated with statin treatment
    • Duncan, A. J.; Hargreaves, I. P.; Damian, M. S.; Land, J. M.; Heales, S. J. Decreased ubiquinone availability and impaired mitochondrial cytochrome oxidase activity associated with statin treatment. Toxicol. Mech. Methods, 2009, 19, 44-50.
    • (2009) Toxicol. Mech. Methods , vol.19 , pp. 44-50
    • Duncan, A.J.1    Hargreaves, I.P.2    Damian, M.S.3    Land, J.M.4    Heales, S.J.5
  • 33
    • 85026134689 scopus 로고    scopus 로고
    • 10 and cardiovascular disease: A review
    • 10 and cardiovascular disease: a review. J. Cardiovasc. Nurs, 2002, 16, 9-20.
    • (2002) J. Cardiovasc. Nurs , vol.16 , pp. 9-20
    • Sarter, B.1
  • 34
    • 84864616144 scopus 로고    scopus 로고
    • Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
    • Muraki, A.; Miyashita, K.; Mitsuishi, M.; Tamaki, M.; Tanaka, K.; Itoh, H. Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. J. Appl. Physiol, 2012, 113, 479-486.
    • (2012) J. Appl. Physiol , vol.113 , pp. 479-486
    • Muraki, A.1    Miyashita, K.2    Mitsuishi, M.3    Tamaki, M.4    Tanaka, K.5    Itoh, H.6
  • 36
    • 77954685883 scopus 로고    scopus 로고
    • Coenzyme Q10: A therapy for hypertension and statin-induced myalgia? Cleve
    • Wyman, M.; Leonard, M.; Morledge, T. Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleve. Clin. J. Med, 2010, 77, 435-442.
    • (2010) Clin. J. Med , vol.77 , pp. 435-442
    • Wyman, M.1    Leonard, M.2    Morledge, T.3
  • 38
    • 33745934695 scopus 로고    scopus 로고
    • Mitochondrial disorder aggravated by propranolol
    • Finsterer, J.; Gelpi, E. Mitochondrial disorder aggravated by propranolol. South. Med. J, 2006, 99, 768-771.
    • (2006) South. Med. J , vol.99 , pp. 768-771
    • Finsterer, J.1    Gelpi, E.2
  • 40
    • 0037797108 scopus 로고    scopus 로고
    • Colesevelam HCl: A non-systemic lipidaltering drug
    • Bays, H.; Dujovne, C. Colesevelam HCl: a non-systemic lipidaltering drug. Expert Opin. Pharmacother, 2003, 4, 779-790.
    • (2003) Expert Opin. Pharmacother , vol.4 , pp. 779-790
    • Bays, H.1    Dujovne, C.2
  • 41
    • 84873147810 scopus 로고    scopus 로고
    • Colesevelam hydrochloride: Evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action
    • Zema, M. J. Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action. Core Evid, 2012, 7, 61-75.
    • (2012) Core Evid , vol.7 , pp. 61-75
    • Zema, M.J.1
  • 42
    • 84887909322 scopus 로고    scopus 로고
    • Sankyo Parke Davis, Parsippany, NJ, (PI revised 07/2000) reviewed 07/2000, (access June 2012)
    • Product Information: Welchol(TM), colesevelam hydrochloride. Sankyo Parke Davis, Parsippany, NJ, (PI revised 07/2000) reviewed 07/2000, (access June 2012).
    • Product Information: Welchol(TM), colesevelam hydrochloride
  • 43
    • 84857039646 scopus 로고    scopus 로고
    • Efficacy of colesevelam on lowering glycemia and lipids
    • Aggarwal, S.; Loomba, R. S.; Arora, R. R. Efficacy of colesevelam on lowering glycemia and lipids. J. Cardiovasc. Pharmacol, 2012, 59, 198-205.
    • (2012) J. Cardiovasc. Pharmacol , vol.59 , pp. 198-205
    • Aggarwal, S.1    Loomba, R.S.2    Arora, R.R.3
  • 44
    • 84864216037 scopus 로고    scopus 로고
    • Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus
    • Goldberg, R. B.; Rosenson, R. S.; Hernandez-Triana, E.; Misir, S.; Jones, M. R. Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus. J. Clin. Lipidol, 2012, 6, 318-324.
    • (2012) J. Clin. Lipidol , vol.6 , pp. 318-324
    • Goldberg, R.B.1    Rosenson, R.S.2    Hernandez-Triana, E.3    Misir, S.4    Jones, M.R.5
  • 45
    • 84874156268 scopus 로고    scopus 로고
    • Colesevelam for type 2 diabetes mellitus
    • doi: 10. 1002/14651858. CD009361. pub2, (access June 2012)
    • Ooi, C. P.; Loke, S. C. Colesevelam for type 2 diabetes mellitus. Cochrane Database Syst. Rev., 2012, 12, CD009361. doi: 10. 1002/14651858. CD009361. pub2, (access June 2012).
    • (2012) Cochrane Database Syst. Rev , vol.12
    • Ooi, C.P.1    Loke, S.C.2
  • 46
    • 84887894965 scopus 로고    scopus 로고
    • (access July), Drug patent watch, ACTOS
    • Drug patent watch. Drug patent expirations and intelligence. ACTOS. http://drugpatentwatch. com/ultimate/preview/tradename/index. php?query=ACTO, (access July 2012).
    • (2012) Drug patent expirations and intelligence
  • 47
    • 0025769847 scopus 로고
    • Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds
    • (Tokyo)
    • Momose, Y.; Meguro, K.; Ikeda, H.; Hatanaka, C.; Oi, S.; Sohda, T. Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds. Chem. Pharm. Bull. (Tokyo), 1991, 39, 1440-1445.
    • (1991) Chem. Pharm. Bull , vol.39 , pp. 1440-1445
    • Momose, Y.1    Meguro, K.2    Ikeda, H.3    Hatanaka, C.4    Oi, S.5    Sohda, T.6
  • 48
    • 0033851704 scopus 로고    scopus 로고
    • Pioglitazone
    • Gillies, P. S., Dunn, C. J. Pioglitazone. Drugs, 2000, 60, 333-343.
    • (2000) Drugs , vol.60 , pp. 333-343
    • Gillies, P.S.1    Dunn, C.J.2
  • 49
    • 55249125525 scopus 로고    scopus 로고
    • Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferatoractivated receptor gamma agonist
    • Nicolakakis, N.; Aboulkassim, T.; Ongali, B.; Lecrux, C.; Fernandes, P.; Rosa-Neto, P.; Tong, X. K.; Hamel, E. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferatoractivated receptor gamma agonist. J. Neurosci, 2008, 28, 9287-9296.
    • (2008) J. Neurosci , vol.28 , pp. 9287-9296
    • Nicolakakis, N.1    Aboulkassim, T.2    Ongali, B.3    Lecrux, C.4    Fernandes, P.5    Rosa-Neto, P.6    Tong, X.K.7    Hamel, E.8
  • 51
    • 85027958993 scopus 로고    scopus 로고
    • Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products
    • Li, F.; Cai, Z.; Chen, F.; Shi, X.; Zhang, Q.; Chen, S.; Shi, J.; Wang, D. W.; Dong, N. Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products. Basic Res. Cardiol, 2012, 107, 306.
    • (2012) Basic Res. Cardiol , vol.107 , pp. 306
    • Li, F.1    Cai, Z.2    Chen, F.3    Shi, X.4    Zhang, Q.5    Chen, S.6    Shi, J.7    Wang, D.W.8    Dong, N.9
  • 52
    • 84872561751 scopus 로고    scopus 로고
    • Understanding Rechallenge and Resistance in the Tyrosine Kinase Inhibitor Era: Imatinib in Gastrointestinal Stromal Tumor
    • (in press)
    • Agulnik, M.; Giel, J. L. Understanding Rechallenge and Resistance in the Tyrosine Kinase Inhibitor Era: Imatinib in Gastrointestinal Stromal Tumor. Am. J. Clin. Oncol, 2012, (in press).
    • (2012) Am. J. Clin. Oncol
    • Agulnik, M.1    Giel, J.L.2
  • 53
    • 84867330680 scopus 로고    scopus 로고
    • Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFR rearrangement and type 1 diabetes
    • Salaroli, A.; Loglisci, G.; Serrao, A.; Alimena, G.; Breccia, M. Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFR rearrangement and type 1 diabetes. Ann. Hematol, 2012, 91, 1823-1824.
    • (2012) Ann. Hematol , vol.91 , pp. 1823-1824
    • Salaroli, A.1    Loglisci, G.2    Serrao, A.3    Alimena, G.4    Breccia, M.5
  • 54
    • 84867800328 scopus 로고    scopus 로고
    • Rapid amelioration of hyperglycemia facilitated by dasatinib in a chronic myeloid leukemia patient with type 2 diabetes mellitus
    • Ono, K.; Suzushima, H.; Watanabe, Y.; Kikukawa, Y.; Shimomura, T.; Furukawa, N.; Kawaguchi, T.; Araki, E. Rapid amelioration of hyperglycemia facilitated by dasatinib in a chronic myeloid leukemia patient with type 2 diabetes mellitus. Intern. Med, 2012, 51, 2763-2766.
    • (2012) Intern. Med , vol.51 , pp. 2763-2766
    • Ono, K.1    Suzushima, H.2    Watanabe, Y.3    Kikukawa, Y.4    Shimomura, T.5    Furukawa, N.6    Kawaguchi, T.7    Araki, E.8
  • 55
    • 84872940798 scopus 로고    scopus 로고
    • Nilotinib exacerbates diabetes mellitus by decreasing secretion of endogenous insulin
    • Ito, Y.; Miyamoto, T.; Chong, Y.; Maki, T.; Akashi, K.; Kamimura, T. Nilotinib exacerbates diabetes mellitus by decreasing secretion of endogenous insulin. Int. J. Hematol., 2013, 97, 135-138.
    • (2013) Int. J. Hematol , vol.97 , pp. 135-138
    • Ito, Y.1    Miyamoto, T.2    Chong, Y.3    Maki, T.4    Akashi, K.5    Kamimura, T.6
  • 56
    • 84862173517 scopus 로고    scopus 로고
    • Dreug repositioning: Extracting added value from prior R&D investments
    • Mucke, H. A. M. Dreug repositioning: extracting added value from prior R&D investments. Insight Pharma. Report, 2010.
    • (2010) Insight Pharma. Report
    • Mucke, H.A.M.1
  • 60
    • 39249084415 scopus 로고    scopus 로고
    • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    • Peng, Q.; Masuda, N.; Jiang, M.; Li, Q.; Zhao, M.; Ross, C. A.; Duan, W. The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model. Exp. Neurol, 2008, 210, 154-163.
    • (2008) Exp. Neurol , vol.210 , pp. 154-163
    • Peng, Q.1    Masuda, N.2    Jiang, M.3    Li, Q.4    Zhao, M.5    Ross, C.A.6    Duan, W.7
  • 62
    • 67649522902 scopus 로고    scopus 로고
    • Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity
    • Jang, S.-W.; Liu, X.; Chan, C.-B.; Weinshenker, D.; Hall, R. A.; Xiao, G.; Ye, K. Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem. Biol, 2009, 16, 644-656.
    • (2009) Chem. Biol , vol.16 , pp. 644-656
    • Jang, S.-W.1    Liu, X.2    Chan, C.-B.3    Weinshenker, D.4    Hall, R.A.5    Xiao, G.6    Ye, K.7
  • 65
    • 80052712639 scopus 로고    scopus 로고
    • Clinical and experimental applications of sodium phenylbutyrate
    • Iannitti, T.; Palmieri, B. Clinical and experimental applications of sodium phenylbutyrate. Drugs R D, 2011, 11, 227-249.
    • (2011) Drugs R D , vol.11 , pp. 227-249
    • Iannitti, T.1    Palmieri, B.2
  • 66
    • 0031889082 scopus 로고    scopus 로고
    • A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: Partial restoration of nasal epithelial CFTR function
    • Rubenstein, R. C.; Zeitlin, P. L. A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. Am. J. Respir. Crit. Care Med, 1998, 157, 484-490.
    • (1998) Am. J. Respir. Crit. Care Med , vol.157 , pp. 484-490
    • Rubenstein, R.C.1    Zeitlin, P.L.2
  • 67
    • 0035145334 scopus 로고    scopus 로고
    • Alternative pathway therapy for urea cycle disorders: Twenty years later
    • Batshaw, M. L.; MacArthur, R. B.; Tuchman, M. Alternative pathway therapy for urea cycle disorders: twenty years later. J. Pediatr, 2001, 138(suppl 1), S46-S55.
    • (2001) J. Pediatr , vol.138 , Issue.SUPPL. 1
    • Batshaw, M.L.1    McArthur, R.B.2    Tuchman, M.3
  • 69
    • 84865142947 scopus 로고    scopus 로고
    • Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2
    • Gonzales, E.; Grosse, B.; Cassio, D.; Davit-Spraul, A.; Fabre, M.; Jacquemin, E. Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2. J. Hepatol, 2012, 57, 695-698.
    • (2012) J. Hepatol , vol.57 , pp. 695-698
    • Gonzales, E.1    Grosse, B.2    Cassio, D.3    Davit-Spraul, A.4    Fabre, M.5    Jacquemin, E.6
  • 70
    • 84868678406 scopus 로고    scopus 로고
    • Progressive familial intrahepatic cholestasis
    • Jacquemin, E. Progressive familial intrahepatic cholestasis. Clin. Res. Hepatol. Gastroenterol, 2012, 36(suppl 1), S26-S35.
    • (2012) Clin. Res. Hepatol. Gastroenterol , vol.36 , Issue.SUPPL. 1
    • Jacquemin, E.1
  • 71
    • 84862487151 scopus 로고    scopus 로고
    • Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease
    • doi: 10. 1371/journal. pone. 0038113, (access September 2012)
    • Roy, A.; Ghosh, A.; Jana, A.; Liu, X.; Brahmachari, S.; Gendelman, H. E.; Pahan, K. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One, 2012, 7, e38113. doi: 10. 1371/journal. pone. 0038113, (access September 2012).
    • (2012) PLoS One , vol.7
    • Roy, A.1    Ghosh, A.2    Jana, A.3    Liu, X.4    Brahmachari, S.5    Gendelman, H.E.6    Pahan, K.7


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