Sapropterin dihydrochloride, 6-R-L-erythro-5,6,7,8- tetrahydrobiopterin, in the treatment of phenylketonuria

Expert Opinion on Investigational Drugs

Volumn 17, Issue 2, 2008, Pages 245-251

  Michals Matalon, Kimberlee ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Phenylalanine; Phenylalanine hydroxylase; Phenylketonuria; Tetrahydrobiopterin (BH4)

Indexed keywords

AROMATIC AMINO ACID; CHAPERONE; DIHYDROPTERIDINE REDUCTASE; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MUTANT PROTEIN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; PLACEBO; PTERIN DERIVATIVE; QUINONE DERIVATIVE; SAPROPTERIN; TETRAHYDROBIOPTERIN; TRYPTOPHAN; TYROSINE; 5,6,7,8-TETRAHYDROBIOPTERIN; BIOPTERIN; DRUG DERIVATIVE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; CLINICAL TRIAL; DIET RESTRICTION; DRUG ABSORPTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG SYNTHESIS; HUMAN; HYPERPHENYLALANINEMIA; MAXIMUM PLASMA CONCENTRATION; MOLECULAR GENETICS; MULTIPLE CYCLE TREATMENT; NONSENSE MUTATION; PHENYLKETONURIA; REVIEW; SINGLE DRUG DOSE; TREATMENT OUTCOME; ANIMAL; BIOSYNTHESIS; BLOOD; GENETICS; GENOTYPE;

ANIMALS; BIOPTERIN; CLINICAL TRIALS AS TOPIC; GENOTYPE; HUMANS; PHENYLALANINE; PHENYLKETONURIAS;

EID: 39049099124     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.2.245     Document Type: Review

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