Metabolomics identifies a biological response to chronic low-dose natural uranium contamination in urine samples

Metabolomics

Volumn 9, Issue 6, 2013, Pages 1168-1180

  Grison, Stéphane ^a   Favé, Gaëlle ^b,c,d   Maillot, Matthieu ^b,c,d   Manens, Line ^a   Delissen, Olivia ^a   Blanchardon, Eric ^a   Banzet, Nathalie ^b,c,d   Defoort, Catherine ^b,c,d   Bott, Romain ^b,c,d   Dublineau, Isabelle ^a   Aigueperse, Jocelyne ^a   Gourmelon, Patrick ^a   Martin, Jean Charles ^b,c,d   Souidi, Maâmar ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c INSERM   (France)

^d INSERM   (France)

Author keywords

Chronic; Low dose; Metabolomics; N methylnicotinamide; Uranium; Urine

Indexed keywords

4,6-DIHYDROXYQUINOLINE; 5 HYDROXYINDOLEACETIC ACID; CREATINE; DRINKING WATER; N METHYLNICOTINAMIDE; NICOTINAMIDE; NICOTINIC ACID; QUINOLINE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG; URANIUM;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BLOOD CELL COUNT; CALIBRATION; CONTROLLED STUDY; CREATININE CLEARANCE; DOSE KIDNEY FUNCTION RELATION; ELECTROSPRAY; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; RAT; RECEIVER OPERATING CHARACTERISTIC; SIGNAL NOISE RATIO; URINALYSIS;

EID: 84887885124     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-013-0544-7     Document Type: Article

References (40)

1. Arogunjo, A. M., Hollriegl, V., Giussani, A., Leopold, K., Gerstmann, U., Veronese, I., et al. (2009). Uranium and thorium in soils, mineral sands, water and food samples in a tin mining area in Nigeria with elevated activity. Journal of Environmental Radioactivity, 100(3), 232-240.
2. Berradi, H., Bertho, J. M., Dudoignon, N., Mazur, A., Grandcolas, L., Baudelin, C., et al. (2008). Renal anemia induced by chronic ingestion of depleted uranium in rats. Toxicological Sciences, 103(2), 397-408.
3. Blantz, R. C. (1975). The mechanism of acute renal failure after uranyl nitrate. [Clinical Trial Research Support, US Gov't, Non-P. H. S. Research Support, US Gov't, P. H. S.]. Journal of Clinical Investigation, 55(3), 621-635. doi: 10. 1172/JCI107970.
4. Bleise, A., Danesi, P. R., & Burkart, W. (2003). Properties, use and health effects of depleted uranium (DU): A general overview. Journal of Environmental Radioactivity, 64(2-3), 93-112.
5. Briner, W. (2010). The toxicity of depleted uranium. International Journal of Environmental Research and Public Health, 7(1), 303-313.
6. Bussy, C., Lestaevel, P., Dhieux, B., Amourette, C., Paquet, F., Gourmelon, P., et al. (2006). Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain. Neurotoxicology, 27(2), 245-252.
7. Corona, G., Rizzolio, F., Giordano, A., & Toffoli, G. (2012). Pharmaco-metabolomics: an emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets. Journal of Cellular Physiology, 227(7), 2827-2831.
8. Craft, E., Abu-Qare, A., Flaherty, M., Garofolo, M., Rincavage, H., & Abou-Donia, M. (2004). Depleted and natural uranium: chemistry and toxicological effects. Journal of Toxicology and Environmental Health, Part B. Critical Reviews, 7(4), 297-317.
9. De Santis, M., Cesari, E., Nobili, E., Straface, G., Cavaliere, A. F., & Caruso, A. (2007). Radiation effects on development. Birth Defects Research Part C: Embryo Today, 81(3), 177-182.
10. Draper, J., Enot, D. P., Parker, D., Beckmann, M., Snowdon, S., Lin, W., et al. (2009). Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'. BMC Bioinformatics, 10, 227.
11. Dublineau, I., Grandcolas, L., Grison, S., Baudelin, C., Paquet, F., Voisin, P., et al. (2007). Modifications of inflammatory pathways in rat intestine following chronic ingestion of depleted uranium. [Research Support, Non-US Gov't]. Toxicological Sciences, 98(2), 458-468. doi: 10. 1093/toxsci/kfm132.
12. Dublineau, I., Grison, S., Grandcolas, L., Baudelin, C., Tessier, C., Suhard, D., et al. (2006). Absorption, accumulation and biological effects of depleted uranium in Peyer's patches of rats. [In Vitro Research Support, Non-US Gov't]. Toxicology, 227(3), 227-239. doi: 10. 1016/j. tox. 2006. 08. 010.
13. Ejnik, J. W., Hamilton, M. M., Adams, P. R., & Carmichael, A. J. (2000). Optimal sample preparation conditions for the determination of uranium in biological samples by kinetic phosphorescence analysis (KPA). Journal of Pharmaceutical and Biomedical Analysis, 24(2), 227-235.
14. European-Commission. (2011). EUR 24756 EN - Study on the longer-term impact of European Union funding of research in the field of Environment and Health. Luxembourg: Publications Office of the European Union.
15. Feugier, A., Frelon, S., Gourmelon, P., & Claraz, M. (2008). Alteration of mouse oocyte quality after a subchronic exposure to depleted Uranium. Reproductive Toxicology, 26(3-4), 273-277.
16. Gagnaire, B., Adam-Guillermin, C., Bouron, A., & Lestaevel, P. (2010). The effects of radionuclides on animal behavior. Reviews of Environmental Contamination and Toxicology, 210, 35-58.
17. Griffin, J. L., Walker, L. A., Shore, R. F., & Nicholson, J. K. (2001). Metabolic profiling of chronic cadmium exposure in the rat. Chemical Research in Toxicology, 14(10), 1428-1434.
18. Grison, S., Martin, J. C., Grandcolas, L., Banzet, N., Blanchardon, E., Tourlonias, E., et al. (2012). The metabolomic approach identifies a biological signature of low-dose chronic exposure to cesium 137. Journal of Radiation Research, 53(1), 33-43.
19. Gueguen, Y., Grandcolas, L., Baudelin, C., Grison, S., Tissandie, E., Jourdain, J. R., et al. (2007). Effect of acetaminophen administration to rats chronically exposed to depleted uranium. Toxicology, 229(1-2), 62-72.
20. Haley, D. P., Bulger, R. E., & Dobyan, D. C. (1982). The long-term effects of uranyl nitrate on the structure and function of the rat kidney. [Research Support, US Gov't, P. H. S.]. Virchows Archiv. B, Cell pathology including molecular pathology, 41(1-2), 181-192.
21. Handley-Sidhu, S., Keith-Roach, M. J., Lloyd, J. R., & Vaughan, D. J. (2010). A review of the environmental corrosion, fate and bioavailability of munitions grade depleted uranium. Science of the Total Environment, 408(23), 5690-5700.
22. Kathren, R. L., & Burklin, R. K. (2008). Acute chemical toxicity of uranium. Health Physics, 94(2), 170-179.
23. Leggett, R. W. (1989). The behavior and chemical toxicity of U in the kidney: a reassessment. [Review]. Health Physics, 57(3), 365-383.
24. Lestaevel, P., Romero, E., Dhieux, B., Ben Soussan, H., Berradi, H., Dublineau, I., et al. (2009). Different pattern of brain pro-/anti-oxidant activity between depleted and enriched uranium in chronically exposed rats. Toxicology, 258(1), 1-9.
25. Magdo, H. S., Forman, J., Graber, N., Newman, B., Klein, K., Satlin, L., et al. (2007). Grand rounds: nephrotoxicity in a young child exposed to uranium from contaminated well water. [Case Reports Research Support, N. I. H., Extramural Research Support, Non-US Gov't Research Support, US Gov't, Non-P. H. S.]. Environmental Health Perspectives, 115(8), 1237-1241. doi: 10. 1289/ehp. 9707.
26. Paquet, F., Houpert, P., Blanchardon, E., Delissen, O., Maubert, C., Dhieux, B., et al. (2006). Accumulation and distribution of uranium in rats after chronic exposure by ingestion. Health Physics, 90(2), 139-147.
27. Racine, R., Grandcolas, L., Grison, S., Stefani, J., Delissen, O., Gourmelon, P., et al. (2010). Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat. Journal of Steroid Biochemistry and Molecular Biology, 120(1), 60-66.
28. 238U series radionuclides as a source of increased radioactivity in groundwater originating from Finnish bedrock: Proceedings of the Helsinki Conference. IAHS Publ, 222, 71.
29. Schwenk, M., Gundert-Remy, U., Heinemeyer, G., Olejniczak, K., Stahlmann, R., Kaufmann, W., et al. (2003). Children as a sensitive subgroup and their role in regulatory toxicology: DGPT workshop report. Archives of Toxicology, 77(1), 2-6.
30. Senn, T., Hazen, S. L., & Tang, W. H. (2012). Translating metabolomics to cardiovascular biomarkers. [Research Support, N. I. H., Extramural Review]. Progress in Cardiovascular Diseases, 55(1), 70-76. doi: 10. 1016/j. pcad. 2012. 06. 004.
31. Shim, C. K., Sawada, Y., Iga, T., & Hanano, M. (1984). Estimation of renal secretory function for organic cations by endogenous N1-methylnicotinamide in rats with experimental renal failure. Journal of Pharmacokinetics and Biopharmaceutics, 12(1), 23-42.
32. Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., & Siuzdak, G. (2006). XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Analytical Chemistry, 78(3), 779-787.
33. Souidi, M., Gueguen, Y., Linard, C., Dudoignon, N., Grison, S., Baudelin, C., et al. (2005). In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. Toxicology, 214(1-2), 113-122.
34. Souidi, M., Tissandie, E., Racine, R., Ben Soussan, H., Rouas, C., Grignard, E., et al. (2009). Uranium: Properties and biological effects after internal contamination. Annals of Clinical Biology (Paris), 67(1), 23-38.
35. Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., et al. (2007). Proposed minimum reporting standards for chemical analysis. Metabolomics, 3(3), 211-221.
36. Tissandie, E., Gueguen, Y., Lobaccaro, J. M., Grandcolas, L., Voisin, P., Aigueperse, J., et al. (2007). In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat. Biochimica et Biophysica Acta, 1770(2), 266-272.
37. Wade-Gueye, N. M., Delissen, O., Gourmelon, P., Aigueperse, J., Dublineau, I., & Souidi, M. (2012). Chronic exposure to natural uranium via drinking water affects bone in growing rats. [Comparative Study Research Support, Non-US Gov't]. Biochimica et Biophysica Acta, 1820(7), 1121-1127. doi: 10. 1016/j. bbagen. 2012. 04. 019.
38. Wang, L., & Pinkerton, K. E. (2007). Air pollutant effects on fetal and early postnatal development. Birth Defects Research Part C: Embryo Today, 81(3), 144-154.
39. Wappelhorst, O., Kuhn, I., Heidenreich, H., & Markert, B. (2002). Transfer of selected elements from food into human milk. Nutrition, 18(4), 316-322.
40. Zhang, A., Sun, H., & Wang, X. (2012). Serum metabolomics as a novel diagnostic approach for disease: a systematic review. [Research Support, Non-US Gov't]. Analytical and Bioanalytical Chemistry, 404(4), 1239-1245. doi: 10. 1007/s00216-012-6117-1.