Substrate stiffness influences the outcome of antitumor drug screening in vitro

Clinical Hemorheology and Microcirculation

Volumn 55, Issue 1, 2013, Pages 121-131

  Feng, Jiantao ^a,b   Tang, Yong ^a   Xu, Yonggang ^c   Sun, Quanmei ^a,b   Liao, Fulong ^a,d   Han, Dong ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b Tsinghua University   (China)

^c XIYUAN HOSPITAL   (China)

^d INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

drug screening system; microenvironment; pharmacology; Stiffness; tumor

Indexed keywords

CISPLATIN; DIMETICONE; PACLITAXEL; PLASTIC;

ARTICLE; ARTICULAR CARTILAGE; BONE DISEASE; BREAST TUMOR; CELL CYCLE PROGRESSION; CELL STRAIN MCF 7; COLLAGENOUS BONE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG SENSITIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; RIGIDITY; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT;

DRUG SCREENING SYSTEM; MICROENVIRONMENT; PHARMACOLOGY; STIFFNESS; TUMOR;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CISPLATIN; COLLAGEN; DIMETHYLPOLYSILOXANES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; PACLITAXEL; STRESS, MECHANICAL;

EID: 84887857597     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-131696     Document Type: Article

References (32)

1. S. Bhattacharyya, J. Wei and J. Varga, Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities, Nature Reviews Rheumatology 8 (2011), 42-54
2. S. Braune, A. Hoñow, C. Mrowietz, J. Cui, K. Kratz, J. Hellwig, C. Ü züm, R. Klitzing, A. Lendlein and F. Jung, Hemocompatibility of soft hydrophobic poly (n-butyl acrylate) networks with elastic moduli adapted to the elasticity of human arteries, Clin Hemorheol Microcirc 49 (2011), 375-390
3. A.J. Engler, S. Sen, H.L. Sweeney and D.E. Discher, Matrix elasticity directs stem cell lineage specification, Cell 126 (2006), 677-689
4. I.J. Fidler, S.J. Kim and R.R. Langley, The role of the organ microenvironment in the biology and therapy of cancer metastasis, Journal of Cellular Biochemistry 101 (2006), 927-936
5. P.M. Gilbert, K.L. Havenstrite, K.E.G. Magnusson, A. Sacco, N.A. Leonardi, P. Kraft, N.K. Nguyen, S. Thrun, M.P. Lutolf and H.M. Blau, Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture, Science Signalling 329 (2010), 1078
6. W.N. Hait, Anticancer drug development: The grand challenges, Nature Reviews Drug Discovery 9 (2010), 253-254
7. S.L. Holbeck, J.M. Collins and J.H. Doroshow, Analysis of food and drug administration-approved anticancer agents in the NCI60 panel of human tumor cell lines, Molecular Cancer Therapeutics 9 (2010), 1451
8. F. Jung, J. Goers, T. Roch, A. Zaupa, B. Pierce, A. Neffe and A. Lendlein, Physically crosslinked gelatins functionalized with tyrosine moieties do not induce angiogenesis or thrombus formation in the developing vasculature in the avian chorioallantoic membrane, Clin Hemorheol Microcirc 50 (2012), 55-63
9. H. Kobayashi, Y. Takemura and T. Ohnuma, Relationship between tumor cell density and drug concentration and the cytotoxic effects of doxorubicin or vincristine: Mechanism of inoculum effects, Cancer Chemotherapy and Pharmacology 31 (1992), 6-10
10. A. Kostic, C.D. Lynch and M.P. Sheetz, Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism, PLoS One 4 (2009), e6361
11. A. Krüger, S. Braune, K. Kratz, A. Lendlein and F. Jung, The influence of poly (n-butyl acrylate) networks on viability and function of smooth muscle cells and vascular fibroblasts, Clin Hemorheol Microcirc 52 (2012), 283-294
12. K.R. Levental, H. Yu, L. Kass, J.N. Lakins, M. Egeblad, J.T. Erler, S.F.T. Fong, K. Csiszar, A. Giaccia and W. Weninger, Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell 139 (2009), 891-906
13. F. Liao and D. Han, Biomechanopharmacology: A new discipline interfacing hemorheology and pharmacology, Biorheology 39 (2002), 652-653
14. F. Liao, M. Li, D. Han, J. Cao and K. Chen, Biomechanopharmacology: A new borderline discipline, Trends in Pharmacological Sciences 27 (2006), 287-289
15. C.M. Lo, H.B. Wang, M. Dembo and Y. Wang, Cell movement is guided by the rigidity of the substrate, Biophysical Journal 79 (2000), 144-152
16. A. Mayer, K. Kratz, B. Hiebl, A. Lendlein and F. Jung, Interaction of angiogenically stimulated intermediate CD163+ monocytes/macrophages with soft hydrophobic poly (n-butyl acrylate) networks with elastic moduli matched to that of human arteries, Artificial Organs 36 (2012), E28-E38
17. J.D. Mih, A.S. Sharif, F. Liu, A. Marinkovic, M.M. Symer and D.J. Tschumperlin, A multiwell platform for studying stiffness-dependent cell biology, PLoS One 6 (2011), e19929
18. A.S. Narang and D.S. Desai, Anticancer Drug Development, Pharmaceutical Perspectives of Cancer Therapeutics (2009), 49-92
19. S. Nemir and J.L. West, Synthetic materials in the study of cell response to substrate rigidity, Annals of Biomedical Engineering 38 (2010), 2-20
20. R.S. O'Connor, X. Hao, K. Shen, K. Bashour, T. Akimova, W.W. Hancock, L.C. Kam and M.C. Milone, Substrate rigidity regulates human T cell activation and proliferation, The Journal of Immunology 189 (2012), 1330-1339
21. Q. Pan, D.G. Li, H.M. Lu, Y.Q. Wang, W.Z. Zhang and Q.F. Xu, A new immortalized rat cell line, hepatic stellate cell-PQ, exhibiting characteristics of hepatic stellate cell, Hepatobiliary Pancreat Dis Int 4 (2005), 281-284
22. M.J. PaszeK, N. Zahir, K.R. Johnson, J.N. Lakins, G.I. Rozenberg, A. Gefen, C.A. Reinhart-King, S.S. Margulies, M. Dembo and D. Boettiger, Tensional homeostasis and the malignant phenotype, Cancer Cell 8 (2005), 241-254
23. F. Rehfeldt, A.J. Engler, A. Eckhardt, F. Ahmed and D.E. Discher, Cell responses to the mechanochemical microenvironment-implications for regenerative medicine and drug delivery, Advanced Drug Delivery Reviews 59 (2007), 1329-1339
24. T. Roch, J. Cui, K. Kratz, A. Lendlein and F. Jung, Immuno-compatibility of soft hydrophobic poly (n-butyl acrylate)networks with elastic moduli for regeneration of functional tissues, Clin Hemorheol Microcirc 50 (2012), 131-142
25. E.L. Schiffrin, Vascular stiffening and arterial compliance, American Journal of Hypertension 17 (2004), 39S-48S.
26. M.A. Shah and G.K. Schwartz, Cell cycle-mediated drug resistance, Clinical Cancer Research 7 (2001), 2168-2181
27. S.V. Sharma, D.A. Haber and J. Settleman, Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents, Nature Reviews Cancer 10 (2010), 241-253
28. R.H. Shoemaker, The NCI60 human tumour cell line anticancer drug screen, Nature Reviews Cancer 6 (2006), 813-823
29. A.I. Teixeira, S. Ilkhanizadeh, J.A. Wigenius, J.K. Duckworth, O. Inganäs and O. Hermanson, The promotion of neuronal maturation on soft substrates, Biomaterials 30 (2009), 4567-4572
30. R.W. Tilghman, C.R. Cowan, J.D. Mih, Y. Koryakina, D. Gioeli, J.K. Slack-Davis, B.R. Blackman, D.J. Tschumperlin and J.T. Parsons, Matrix rigidity regulates cancer cell growth and cellular phenotype, PLoS One 5 (2010), e12905
31. B. Trappmann, J.E. Gautrot, J.T. Connelly, D.G.T. Strange, Y. Li, M.L. Oyen, M.A.C. Stuart, H. Boehm, B. Li and V. Vogel, Extracellular-matrix tethering regulates stem-cell fate, Nature Materials 11 (2012), 642-649
32. U. Yaqoob, S. Cao, U. Shergill, K. Jagavelu, Z. Geng, M. Yin, T.M. de Assuncao, Y. Cao, A. Szabolcs and S. Thorgeirsson, Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment, Cancer Research 72 (2012), 4047-4059.