Inhibition of telomerase recruitment and cancer cell death

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 33171-33180

  Nakashima, Mai ^a,b   Nandakumar, Jayakrishnan ^a,c   Sullivan, Kelly D ^a   Espinosa, Joaquín M ^a   Cech, Thomas R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER THERAPIES; CANCER CELLS; EXPRESSION CASSETTE; HELA CELL LINE; HUMAN CELLS; HUMAN TUMORS; SURVIVAL MECHANISMS; TELOMERE LENGTH;

AMINO ACIDS; CELL CULTURE; CELL DEATH; CHROMOSOMES;

ENZYME INHIBITION;

TELOMERASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL ELONGATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MUTATION RATE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CANCER; CELL BIOLOGY; TELOMERASE; TELOMERES; TPP1;

AMINOBENZOATES; AMINOPEPTIDASES; APOPTOSIS; CELL SURVIVAL; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; HELA CELLS; HUMANS; MUTATION; NAPHTHALENES; NEOPLASMS; SERINE PROTEASES; TELOMERASE;

EID: 84887836986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.518175     Document Type: Article

References (27)

1. Palm, W., and de Lange, T. (2008) How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301-334
2. Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., and Harley, C. B. (1992) Telomere end-replication problem and cell aging. J. Mol. Biol. 225, 951-960
3. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015
4. Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Jr., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., Grollman, A. P., He, T. C., He, Y., Hruban, R. H., Jallo, G. I., Mandahl, N., Meeker, A. K., Mertens, F., Netto, G. J., Rasheed, B. A., Riggins, G. J., Rosenquist, T. A., Schiffman, M., Shih, I. M., Theodorescu, D., Torbenson, M. S., Velculescu, V. E., Wang, T. L., Wentzensen, N., Wood, L. D., Zhang, M., McLendon, R. E., Bigner, D. D., Kinzler, K. W., Vogelstein, B., Papadopoulos, N., and Yan, H. (2013) TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc. Natl. Acad. Sci. U.S.A. 110, 6021-6026
5. Huang, F. W., Hodis, E., Xu, M. J., Kryukov, G. V., Chin, L., and Garraway, L. A. (2013) Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957-959
6. Horn, S., Figl, A., Rachakonda, P. S., Fischer, C., Sucker, A., Gast, A., Kadel, S., Moll, I., Nagore, E., Hemminki, K., Schadendorf, D., and Kumar, R. (2013) TERT promoter mutations in familial and sporadic melanoma. Science 339, 959-961
7. Liu, X., Bishop, J., Shan, Y., Pai, S., Liu, D., Murugan, A. K., Sun, H., El- Naggar, A. K., and Xing, M. (2013) Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr.-Relat. Cancer 20, 603-610
8. Liu, X., Wu, G., Shan, Y., Hartmann, C., von Deimling, A., and Xing, M. (2013) Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. Cell Cycle 12, 1637-1638
9. Arita, H., Narita, Y., Fukushima, S., Tateishi, K., Matsushita, Y., Yoshida, A., Miyakita, Y., Ohno, M., Collins, V. P., Kawahara, N., Shibui, S., and Ichimura, K. (2013) Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 126, 267-276
10. Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., and Cech, T. R. (1997) Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567
11. Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., and Weinberg, R. A. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785-795
12. Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., and Artandi, S. E. (2009) A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science 323, 644-648
13. Cristofari, G., Adolf, E., Reichenbach, P., Sikora, K., Terns, R. M., Terns, M. P., and Lingner, J. (2007) Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. Mol. Cell 27, 882-889
14. Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O'Connor, M. S., and Songyang, Z. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445, 559-562
15. Abreu, E., Aritonovska, E., Reichenbach, P., Cristofari, G., Culp, B., Terns, R. M., Lingner, J., and Terns, M. P. (2010) TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol. Cell. Biol. 30, 2971-2982
16. Nandakumar, J., and Cech, T. R. (2013) Finding the end. Recruitment of telomerase to telomeres. Nat. Rev. Mol. Cell Biol. 14, 69-82
17. Sexton, A. N., Youmans, D. T., and Collins, K. (2012) Specificity requirements for human telomere protein interaction with telomerase holoenzyme. J. Biol. Chem. 287, 34455-34464
18. Nandakumar, J., Bell, C. F., Weidenfeld, I., Zaug, A. J., Leinwand, L. A., and Cech, T. R. (2012) The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature 492, 285-289
19. Zhong, F. L., Batista, L. F., Freund, A., Pech, M. F., Venteicher, A. S., and Artandi, S. E. (2012) TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 150, 481-494
20. Pascolo, E., Wenz, C., Lingner, J., Hauel, N., Priepke, H., Kauffmann, I., Garin-Chesa, P., Rettig, W. J., Damm, K., and Schnapp, A. (2002) Mechanism of human telomerase inhibition by BIBR1532, a synthetic, nonnucleosidic drug candidate. J. Biol. Chem. 277, 15566-15572
21. Damm, K., Hemmann, U., Garin-Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., Guilliard, B., Lauritsch, I., Müller, E., Pascolo, E., Sauter, G., Pantic, M., Martens, U. M., Wenz, C., Lingner, J., Kraut, N., Rettig, W. J., and Schnapp, A. (2001) A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968
22. Latrick, C. M., and Cech, T. R. (2010) POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J. 29, 924-933
23. Takai, H., Smogorzewska, A., and de Lange, T. (2003)DNAdamage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556
24. Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T. (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325
25. Eller, M. S., Puri, N., Hadshiew, I. M., Venna, S. S., and Gilchrest, B. A. (2002) Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp. Cell Res. 276, 185-193
26. El-Daly, H., Kull, M., Zimmermann, S., Pantic, M., Waller, C. F., and Martens, U. M. (2005) Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood 105, 1742-1749
27. Bryan, T. M., Englezou, A., Dalla-Pozza, L., Dunham, M. A., and Reddel, R. R. (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3, 1271-1274