Ultrasound Directs a Transposase System for Durable Hepatic Gene Delivery in Mice

Ultrasound in Medicine and Biology

Volumn 39, Issue 12, 2013, Pages 2351-2361

  Anderson, Cynthia D ^a   Urschitz, Johann ^a   Khemmani, Mark ^a   Owens, Jesse B ^a   Moisyadi, Stefan ^a,b   Shohet, Ralph V ^a   Walton, Chad B ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b Manoa BioSciences   (United States)

Author keywords

Hepatic gene therapy; Microbubbles; Site specific chromosomal integration; Transposase; Ultrasound

Indexed keywords

BLOOD VESSELS; CHROMOSOMES; GENE ENCODING; GENE TRANSFER; INTEGRATION; MAMMALS; ULTRASONICS; VECTORS;

CHROMOSOMAL INTEGRATION; CLONING AND SEQUENCING; GENOMIC INTEGRATION; HEPATIC GENES; MICROBUBBLES; PULSE REPETITION FREQUENCIES; TRANSPOSASE; ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION;

PLANTS (BOTANY);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 6; CONTROLLED STUDY; DNA SEQUENCE; DNA VECTOR; ECHOGRAPHY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER PARENCHYMA; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE; ULTRASOUND TARGETED MICROBUBBLE DESTRUCTION;

HEPATIC GENE THERAPY; MICROBUBBLES; SITE-SPECIFIC CHROMOSOMAL INTEGRATION; TRANSPOSASE; ULTRASOUND;

ANIMALS; DELAYED-ACTION PREPARATIONS; DNA TRANSPOSABLE ELEMENTS; GENETIC VECTORS; HEK293 CELLS; HIGH-ENERGY SHOCK WAVES; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; RADIATION DOSAGE; SONICATION; TRANSFECTION; TRANSPOSASES;

EID: 84887822373     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2013.07.002     Document Type: Article

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