Helper-independent piggyBac plasmids for gene delivery approaches: Strategies for avoiding potential genotoxic effects

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 18, 2010, Pages 8117-8122

  Urschitz, Johann ^a   Kawasumi, Miyuri ^a,b   Owens, Jesse ^a   Morozumi, Kazuto ^a,c   Yamashiro, Hideaki ^a   Stoytchev, Ilko ^a   Marh, Joel ^a   Dee, James A ^a   Kawamoto, Kris ^a   Coates, Craig J ^d,e   Kaminski, Joseph M ^f   Pelczar, Pawel ^e,g   Yanagimachi, Ryuzo ^a   Moisyadi, Stefan ^a,e  

^a UNIVERSITY OF HAWAII   (United States)

^b KEIO UNIVERSITY   (Japan)

^c INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^d TEXAS A AND M UNIVERSITY   (United States)

^e Manoa BioSciences   (United States)

^f CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Gene therapy; Transfection; Transgenesis; Transposase; Transposon

Indexed keywords

PIGGYBAC TRANSPOSASE; PLASMID VECTOR; TRANSPOSASE; UNCLASSIFIED DRUG;

ARTICLE; BIOENGINEERING; CONTROLLED STUDY; EMBRYO; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE THERAPY; GENOTOXICITY; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENICS; TRANSPOSON;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA DAMAGE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MICE; PLASMIDS; TRANSPOSASES;

ANIMALIA;

EID: 77952369001     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003674107     Document Type: Article

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