Time and dose-dependent effects of phenobarbital on the rat liver miRNAome

Toxicology

Volumn 314, Issue 2-3, 2013, Pages 247-253

  Koufaris, Costas ^a,b   Wright, Jayne ^c   Osborne, Michael ^a   Currie, Richard A ^c   Gooderham, Nigel J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^c JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Dose; MicroRNA; Proliferation; Temporal; Xenobiotic

Indexed keywords

CYTOCHROME P450; MICRORNA; MICRORNA 182; MICRORNA 195; MICRORNA 199A; MICRORNA 19B; MICRORNA 200A; MICRORNA 200B; MICRORNA 29B; MICRORNA 324; MICRORNA 429; MICRORNA 494; MICRORNA 93; MICRORNA 96; MICRORNA 99A; PHENOBARBITAL; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CELL PROLIFERATION; DNA METHYLATION; DNA REPLICATION; DRUG EFFECT; HEPATOMEGALY; HYPERPLASIA; IMMUNOBLOTTING; LIVER; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA EXTRACTION;

RATTUS; RODENTIA;

EID: 84887807704     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.10.004     Document Type: Article

References (24)

1. Bracken C.P., Gregory P.A., Kolesnikoff N., Bert A.G., Wang J., Shannon M.F., Goodall G.J. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008, 68(19):7846-7854.
2. Chen H., Sun Y., Dong R., Yang S., Pan C. Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation. PLoS ONE 2011, 6(5):e20238.
3. Counts J.L., Sarmiento J.I., Harbison M.L., Downing J.C., McClain R.M., Goodman J.I. Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration. Carcinogenesis 1996, 17(6):1251-1257.
4. Esau C., Davis S., Murray S.F., Yu X.X., Pandey S.K., et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006, 3:87-98.
5. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E., Liu S., Alder H., Costinean S., Fernandez-Cymering C., Volinia S., Guler G., Morrison C.D., Cha K.K., Marcussi G., Calin G.A., Huebner K.m., Croce C.M. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:15805-15810.
6. Gailhouste L., Gomez-Santos L., Hagiwara K., Hatada I., Kitagawa N., et al. MiR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology 2013, 10.1002/hep.26422.
7. Garzon R., Liu S., Fabbri M., Liu Z., Heaphy C.E., Callegari E., Schwind S., Pang J., Yu J., Muthusamy N., Havelange V., Volinia S., Blum W., Rush L.J., Perrotti D., Andreeff M., Bloomfield C.D., Byrd J., Chan K., Wu L.C., Croce C.M., Marcucci G. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009, 113(25):6411-6418.
8. Kamburov A., Wierling C., Lehrach H., Herwig R. ConsensusPathDB-a database for integrating human functional interaction networks. Nucl. Acids Res. 2009, 37:D623-D628.
9. Koufaris C., Wright J., Currie R.A., Gooderham N.J. Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. Toxicol. Sci. 2012, 128(2):532-543.
10. Koufaris C., Gooderham N.J. Are differences in microRNA regulation implicated in species-dependent response to toxicological exposures?. Toxicol. Sci. 2013, 131(2):337-342.
11. Lempiäinen H., Couttet P., Bolognani F., Müller A., Dubost V., Luisier R., Espinola Adel R., Vitry V., Unterberger E.B., Thomson J.P., Treindl F., Metzger U., Wrzodek C., Hahne F., Zollinger T., Brasa S., Kalteis M., Marcellin M., Giudicelli F., Braeuning A., Morawiec L., Zamurovic N., Längle U., Scheer N., Schübeler D., Goodman J., Chibout S.D., Marlowe J., Theil D., Heard D.J., Grenet O., Zell A., Templin M.F., Meehan R.R., Wolf R.C., Elcombe C.R., Schwarz M., Moulin P., Terranova R., Moggs J.G. Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion. Toxicol. Sci. 2013, 131(2):375-386.
12. Li T., Francl J.M., Boehme S., Chiang J.Y. Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis. Hepatology 2013, 10.1002/hep.26427.
13. Li Z.G., Branham W.S., Dial S.L., Wang Y., Guo L., Shi L., Chen T. Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. BMC Genomics 2010, 11:609.
14. Lu T.P., Lee C.Y., Tsai M.H., Chiu Y.C., Hsiao C.K., et al. miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets. PLoS ONE 2012, 7:e42390.
15. Moffat I.D., Boutros P.C., Celius T., Linden J., Pohjanvirta R., Okey A.B. MicroRNAs in adult rodent liver are refractory to dioxin treatment. Toxicol. Sci. 2007, 99:470-487.
16. Phillips J.M., Burgoon L.D., Goodman J.I. Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. Toxicol. Sci. 2009, 109(June (2)):193-205.
17. Song G.S., Sharma A.D., Roll G.R., Ng R., Lee A.Y., Blelloch R.H., Frandsen N.M., Willenbring H. MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology 2010, 51(5):1735-1743.
18. Taylor E.L., Gant T.W. Emerging fundamental roles for non-coding RNA species in toxicology. Toxicology 2008, 3(246 (1)):34-39.
19. Trajkovski M., Hausser J., Soutschek J., Bhat B., Akin A., et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 2013, 474:649-653.
20. Waterman C.L., Currie R.A., Cottrell L.A., Dow J., Wright J., Waterfield C.F., Griffin J.L. An integrated functional genomic study of acute phenobarbital exposure in the rat. BMC Genomics 2010, 11:9.
21. Whysner J., Ross P.M., Williams G.M. Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 1996, 71(1-2):153-191.
22. Williams G.M., Iatropoulos M.J. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol. Pathol. 2002, 30(1):41-53.
23. Xu S., Witmer P.D., Lumayag S., Kovacs B., Valle D. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J. Biol. Chem. 2007, 282:25053-25066.
24. Yauk C.L., Jackson K., Malowany M.W., Williams A. Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response. Mutat. Res.-Gen. Toxicol. Environ. 2010, 722(2):131-139.