Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 1, 2014, Pages 107-115

  Pedroni, Silvia M A ^a   Gonzalez, Juan M ^b   Wade, Jean ^a   Jansen, Maurits A ^c   Serio, Andrea ^d   Marshall, Ian ^c   Lennen, Ross J ^c   Girardi, Guillermina ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Complement; Cortical fetal brain damage; Glutamate; Preterm birth; Statin

Indexed keywords

COMPLEMENT COMPONENT C5A; COMPLEMENT INHIBITOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; PRAVASTATIN; PROTEIN KINASE B; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; BRAIN CELL; BRAIN CORTEX; BRAIN DAMAGE; BRAIN MALFORMATION; CELL DEATH; CELL SURVIVAL; COGNITIVE DEFECT; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; CYTOARCHITECTURE; FEMALE; FETUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; SOCIALIZATION; TISSUE INJURY;

COMPLEMENT; CORTICAL FETAL BRAIN DAMAGE; GLUTAMATE; PRETERM BIRTH; STATIN;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELLS, CULTURED; CEREBRAL CORTEX; COMPLEMENT ACTIVATION; COMPLEMENT C5A; FEMALE; FETUS; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HUMANS; INFANT, NEWBORN; MICE; MODELS, ANIMAL; NEURONS; PRAVASTATIN; PREGNANCY; PREMATURE BIRTH; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 84887671771     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.10.011     Document Type: Article

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