High expression of astrocyte elevated gene-1 (AEG-1) is associated with progression of cervical intraepithelial neoplasia and unfavorable prognosis in cervical cancer

World Journal of Surgical Oncology

Volumn 11, Issue , 2013, Pages

  Huang, Ke ^a   Li, Li A ^a   Meng, Yuanguang ^a   You, Yanqin ^a   Fu, Xiaoyu ^a   Song, Lei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

AEG 1; Cervical cancer; Prognosis; Tissue microarrays

Indexed keywords

ADULT; AGED; ARTICLE; ASTROCYTE ELEVATED GENE 1; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR GENE; TUMOR VOLUME; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

ADENOCARCINOMA; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 84887642519     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-11-297     Document Type: Article

References (22)

1. Dehn D, Torkko KC, Shroyer KR. Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma. Cancer 2007, 111:1-14. 10.1002/cncr.22425, 17219448.
2. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005, 353:8-15. 10.1016/j.gene.2005.04.006, 15927426.
3. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, Mills AS, Waxman S, Fisher RA, Llovet JM, Fisher PB, Sarkar D. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009, 119:465-477. 10.1172/JCI36460, 2648696, 19221438.
4. Yu C, Chen K, Zheng H, Guo X, Jia W, Li M, Zeng M, Li J, Song L. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009, 30:894-901. 10.1093/carcin/bgp064, 19304953.
5. Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY, Wu J, Yuan J, Zhang HZ, Zeng MS, Li M. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008, 14:3319-3326. 10.1158/1078-0432.CCR-07-4054, 18519759.
6. Song H, Li C, Li R, Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 2010, 25:1201-1209. 10.1007/s00384-010-1009-3, 20625905.
7. Song L, Li W, Zhang H, Liao W, Dai T, Yu C, Ding X, Zhang L, Li J. Overexpression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 2009, 219:317-326. 10.1002/path.2595, 19644957.
8. Jian-bo X, Hui W, Yu-long H, Chang-hua Z, Long-juan Z, Shi-rong C, Wen-hua Z. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 2011, 28:455-462. 10.1007/s12032-010-9475-6, 20300973.
9. Wang F, Ke ZF, Sun SJ, Chen WF, Yang SC, Li SH, Mao XP, Wang LT. Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biol Ther 2011, 12:539-548. 10.4161/cbt.12.6.16301, 21750404.
10. Li J, Yang L, Song L, Xiong H, Wang L, Yan X, Yuan J, Wu J, Li M. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009, 28:3188-3196. 10.1038/onc.2009.171, 19633686.
11. Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K, Fisher PB. Activation of the nuclear factor κB pathway byastrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006, 66:1509-1516. 10.1158/0008-5472.CAN-05-3029, 16452207.
12. Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, Song L, Yuan J, Li J, Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 2010, 70:3750-3759. 10.1158/0008-5472.CAN-09-3838, 20388776.
13. Xie D, Sham JS, Zeng WF, Lin HL, Che LH, Wu HX, Wen JM, Fang Y, Hu L, Guan XY. Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer 2003, 107:896-902. 10.1002/ijc.11514, 14601048.
14. Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX, Xie D. Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci 2010, 101:1543-1549. 10.1111/j.1349-7006.2010.01560.x, 20367640.
15. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Place RF, Pookot D, Majid S, Igawa M, Dahiya R. Knockdown of astrocyte - elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007, 26:7647-7655. 10.1038/sj.onc.1210572, 17563745.
16. Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, Robertson CL, Dumur CI, Hylemon PB, Mukhopadhyay ND, Bhere D, Shah K, Ahmad R, Giashuddin S, Stafflinger J, Subler MA, Windle JJ, Fisher PB, Sarkar D. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology 2012, 56:1782-1791. 10.1002/hep.25868, 3449036, 22689379.
17. Lee SG, Jeon HY, Su ZZ, Richards JE, Vozhilla N, Sarkar D, Van Maerken T, Fisher PB. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009, 28:2476-2484. 10.1038/onc.2009.93, 19448665.
18. Liao WT, Guo L, Zhong Y, Wu YH, Li J, Song LB. Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. J Transl Med 2011, 9:205-215. 10.1186/1479-5876-9-205, 3286424, 22133054.
19. Long M, Dong K, Gao P, Wang X, Liu L, Yang S, Lin F, Wei J, Zhang H. Overexpression of astrocyte-elevated gene-1 is associated with cervical carcinoma progression and angiogenesis. Oncol Rep 2013, 30:1414-1422.
20. Emdad L, Lee SG, Su ZZ, Jeon HY, Boukerche H, Sarkar D, Fisher PB. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 2009, 106:21300-21305. 10.1073/pnas.0910936106, 2795510, 19940250.
21. Ash SC, Yang DQ, Britt DE. LYRIC/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells. Biochem Biophys Res Commun 2008, 371:333-338. 10.1016/j.bbrc.2008.04.084, 2573900, 18440304.
22. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009, 15:9-20. 10.1016/j.ccr.2008.11.013, 2676231, 19111877.