Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease

Clinical Neurology and Neurosurgery

Volumn 115, Issue 9, 2013, Pages 1693-1696

  Mansouri, Leila ^a   Fekih Mrissa, Najiba ^a   Klai, Sarra ^a   Mansour, Malek ^a   Gritli, Nasreddine ^a   Mrissa, Ridha ^a  

^a MILITARY HOSPITAL OF TUNIS   (Tunisia)

Author keywords

Alzheimer's disease; Human; MTHFR protein; Risk factor

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK FACTOR;

ALZHEIMER'S DISEASE; HUMAN; MTHFR PROTEIN; RISK FACTOR;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84887627010     PISSN: 03038467     EISSN: 18726968     Source Type: Journal    
DOI: 10.1016/j.clineuro.2013.03.015     Document Type: Article

References (28)

1. L.L. Fernandez, and R.M. Scheibe Is MTHFR polymorphism a risk factor for Alzheimer disease like APOE? Arquivos de Neuro-Psiquiatria 63 2005 1 6
2. T.S. Wingo, J.J. Lah, A.I. Levey, and D.J. Cutler Autosomal recessive causes likely in early-onset Alzheimer disease Archives of Neurology 69 2012 59 64
3. I. Spiroski, S. Kedev, S. Antov, T. Arsov, M. Krstevska, and S. Dzhekova-Stojkova Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis Acta Biochimica Polonica 55 2008 587 594
4. C. Huerta, V. Alvarez, I.F. Mata, E. Coto, R. Ribacoba, and C. Martinez Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease Neuroscience Letters 370 2004 151 154
5. G.A. Jicha, J.E. Parisi, D.W. Dickson, R.H. Cha, K.A. Johnson, and G.E. Smith Age and apoE associations with complex pathologic features in Alzheimer's disease Journal of the Neurological Sciences 273 2008 34 39
6. M. Nishiyama, Y. Kato, M. Hashimoto, S. Yukawa, K. Omori, and E. Apolipoprotein methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia - an epidemiological study using the polymerase chain reaction (PCR) method Epidemiology 10 2000 163 172
7. R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton, and P.M. Ueland Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease Archives of Neurology 55 1998 1449 1455
8. R. Surtees, J. Leonard, and S. Austin Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway Lancet 338 1991 1550 1554
9. I.M. Graham, L.E. Daly, H.M. Refsum, K. Robinson, L.E. Brattström, and P.M. Ueland Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project JAMA 277 1997 1775 1781
10. D. Religa, K. Czyzewski, M. Styczynska, B. Peplonska, J. Lokk, and M. Chodakowska-Zebrowska Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease Neuroscience Letters 404 2006 56 60
11. N. Fekih-Mrissa, S. Klai, A. Bafoun, B. Nciri, J. Hmida, and N. Gritli Role of thrombophilia in vascular access thrombosis among chronic hemodialysis patients in Tunisia Therapeutic Apheresis and Dialysis 15 2011 40 43
12. S. Klai, N. Fekih-Mrissa, S. El Housaini, N. Kaabechi, B. Nsiri, and R. Rachdi Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies Blood Coagulation and Fibrinolysis 22 2011 374 378
13. J.P. Casas, A.D. Hingorani, L.E. Bautista, and P. Sharma Meta-analysis of genetics studies in ischemic stroke. Thirty-two genes involving approximately 18,000 cases and 58,000 controls Archives of Neurology 61 2004 1652 1662
14. L. Klotz, M. Farkas, N. Bain, S. Keskitalo, A. Semmler, and B. Ineichen The variant methylenetetrahydrofolate reductase c.1298A > C (p.E429A) is associated with multiple sclerosis in a German case-control study Neuroscience Letters 468 2010 183 185
15. P. Goyette, J.S. Sumner, R. Milos, A.M.V. Duncan, D.S. Rosenblatt, and R.G. Matthews Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification Nature Genetics 7 1994 195 200
16. P. Goyette, A. Pai, R. Milos, P. Frosst, P. Tran, and Z. Chen Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Mammalian Genome 9 1998 652 656
17. V.C. da Silva, F.J. Ramos, E.M. Freitas, P.R. de Brito-Marques, M.N. Cavalcanti, and V. D'Almeida Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms Arquivos de Neuro-Psiquiatria 64 2006 941 945
18. E. Strandhagen, H. Zetterberg, N. Aires, M. Palmér, L. Rymo, and K. Blennow The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study International Journal of Molecular Medicine 13 2004 811 815
19. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
20. A.I. Freitas, I. Mendonça, G. Guerra, M. Brión, R.P. Reis, and A. Carracedo Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal) Thrombosis Research 122 2008 648 656
21. D. Religa, M. Styczynska, B. Peplonska, T. Gabryelewicz, A. Pfeffer, and M. Chodakowska Homocysteine, apolipoprotein E and methylenetetrahydrofolate reductase in Alzheimer1s disease and mild cognitive impairment Dementia and Geriatric Cognitive Disorders 16 2003 64 70
22. B. Regland, K. Blennow, T. Germgard, A.C. Koch-Schmidt, and C.G. Gottfries The role of polymorphic genes apolipoprotein E and methylenotetrahidrofolate reductase in the development of dementia of Alzheimer type Dementia and Geriatric Cognitive Disorders 10 1999 245 251
23. A. Postiglione, G. Milan, A. Ruoceo, G. Gallotta, G. Guiotto, and G. Di Minno Plasma folate, vitamin B12, and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia: a case-control study Gerontology 47 2001 324 329
24. T. Brunelli, S. Bagnoli, B. Giusti, B. Nacmias, G. Pepe, and S. Sorbi The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease Neuroscience Letters 315 2001 103 105
25. J.A. Prince, L. Feuk, S.L. Sawyer, J. Gottfries, A. Ricksten, and K. Nägga Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease European Journal of Human Genetics 9 2001 437 444
26. D. Seripa, G.D. Forno, M.G. Matera, C. Gravina, M. Margaglione, and M.T. Palermo Methylenetetrahydrofolate reductase, angiotensin converting enzyme gene polymorphisms in two genetically, and diagnostically distinct cohort of Alzheimer patients Neurobiology of Aging 24 2003 933 939
27. Y. Wakutani, H. Kowa, M. Kusumi, K. Nakaso, K. Yasui, and K. Isoe-Wada A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease Neurobiology of Aging 25 2004 291 294
28. P. Bosco, R.M. Guéant-Rodríguez, G. Anello, A. Romano, B. Namour, and R.S. Spada Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease Journal of Neurology, Neurosurgery and Psychiatry 75 2004 1036 1038