Antidepressant-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodents

Pharmacology Biochemistry and Behavior

Volumn 114-115, Issue , 2013, Pages 23-30

  Yamada, Koji ^a   Kobayashi, Minoru ^a   Mori, Akihisa ^a   Jenner, Peter ^b   Kanda, Tomoyuki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b Centre for Research in Rehabilitation School of Health Science and Social Care   (United Kingdom)

Author keywords

Adenosine A2A receptor; Antidepressant; Forced swimming test; Istradefylline; KW 6002; Tail suspension test

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADENOSINE A2 RECEPTOR; ANTIDEPRESSANT AGENT; CORTICOSTERONE; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; ISTRADEFYLLINE; PAROXETINE; QUINPIROLE; SELEGILINE; VENLAFAXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; EXPERIMENTAL TEST; FORCED SWIMMING TEST; IMMOBILITY; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; TAIL; TAIL SUSPENSION TEST;

MUS; RATTUS; RODENTIA;

5-HT; 5-HYDROXYTRYPTAMINE; 50% EFFECTIVE DOSE; 8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN; 8-OH-DPAT; ACTH; ADENOSINE A(2A) RECEPTOR; ADRENOCORTICOTROPIC HORMONE; ANTIDEPRESSANT; CATECHOLAMINE-O-METHYLTRANSFERASE; COMT; ED(50); FORCED SWIM TEST; FORCED SWIMMING TEST; FST; HPA; HYPOTHALAMIC-PITUITARY-ADRENAL; ISTRADEFYLLINE; KW-6002; MAO; MED; MINIMUM EFFECTIVE DOSE; MONOAMINE OXIDASE; PARKINSON'S DISEASE; PD; SEROTONIN NORADRENALINE REUPTAKE INHIBITOR; SEROTONIN-NORADRENALINE REUPTAKE INHIBITOR; SNRI; SSRI; TAIL SUSPENSION TEST; TCA; TRICYCLIC ANTIDEPRESSANT; TST;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; MALE; MICE; PURINES; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL; SWIMMING;

EID: 84887588837     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.10.022     Document Type: Article

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