Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 10, 2013, Pages

  Gladden, James D ^a,b   Zelickson, Blake R ^a,c   Guichard, Jason L ^a,b   Ahmed, Mustafa I ^a,b   Yancey, Danielle M ^a,b   Ballinger, Scott ^a,c,d   Shanmugam, Mayilvahanan ^e   Babu, Gopal J ^e   Johnson, Michelle S ^c,d   Darley Usmar, Victor ^a,c,d   Dell'Italia, Louis J ^a,b,f  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^f BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Heart failure; Mitochondria; Volume overload; Xanthine oxidase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALLOPURINOL; OXYGEN; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

ANALYZER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTOCAVAL FISTULA; ARTICLE; BIOENERGY; BLOOD FLOW VELOCITY; CALCIUM SIGNALING; CONTROLLED STUDY; DISEASE SEVERITY; ECHOCARDIOGRAPHY; ENZYME INHIBITION; EXTRACELLULAR FLUID; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE OVERLOAD; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE COMPLIANCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART STRESS; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VOLUME; HEMODYNAMIC STRESS; HOSPITALIZATION; HYPOTHESIS; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; LUNG WEIGHT; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MITRAL VALVE REGURGITATION; MYOFILAMENT; NONHUMAN; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; RAT; SYSTOLE; VELOCITY;

HEART FAILURE; MITOCHONDRIA; VOLUME OVERLOAD; XANTHINE OXIDASE;

ADENOSINE TRIPHOSPHATE; ALLOPURINOL; ANIMALS; CALCIUM SIGNALING; CARDIOTONIC AGENTS; CREATINE KINASE; DIASTOLE; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; ENZYME INHIBITORS; HEART FAILURE; HEART VENTRICLES; HEMODYNAMICS; MYOCYTES, CARDIAC; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM; STROKE VOLUME; SYSTOLE; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE; XANTHINE OXIDASE;

EID: 84887577497     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00007.2013     Document Type: Article

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