Children with celiac disease and high tTGA are genetically and phenotypically different

World Journal of Gastroenterology

Volumn 19, Issue 41, 2013, Pages 7114-7120

  Mubarak, Amani ^a   Spierings, Eric ^b   Wolters, Victorien M ^a   Otten, Henny G ^b   ten Kate, Fiebo J W ^b   Houwen, Roderick H J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Anti tissue transglutaminase antibodies; Celiac disease; Human leukocyte antigen; Phenotype; Serology

Indexed keywords

HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; HETERODIMER; HLA ANTIGEN; HLA DQ ANTIGEN; HLA DQ2.2 ANTIGEN; HLA DQ2.5 ANTIGEN; HLA DQ8 ANTIGEN; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; BIOPSY; CELIAC DISEASE; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL SYMPTOM; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; PHENOTYPIC VARIATION; POLYMERASE CHAIN REACTION; ABDOMINAL PAIN; ANEMIA; APHTHOUS STOMATITIS; GASTROINTESTINAL BIOPSY; HISTOLOGY; NAUSEA; PATHOLOGIST; PHENOTYPE;

ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES; CELIAC DISEASE; HUMAN LEUKOCYTE ANTIGEN; PHENOTYPE; SEROLOGY;

ADOLESCENT; AGE FACTORS; ASYMPTOMATIC DISEASES; AUTOANTIBODIES; BIOPSY; CELIAC DISEASE; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; DUODENUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HLA-DQ ANTIGENS; HUMANS; IMMUNOGLOBULIN A; INFANT; INFANT, NEWBORN; MALE; PHENOTYPE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TRANSGLUTAMINASES;

EID: 84887547142     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i41.7114     Document Type: Article

References (26)

1. Ferguson A, Arranz E, O'Mahony S. Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential. Gut 1993; 34: 150-151 [PMID: 8432463 DOI: 10.1136/ gut.34.2.150.Ferguson]
2. Catassi C, Fabiani E, Rätsch IM, Coppa GV, Giorgi PL, Pierdomenico R, Alessandrini S, Iwanejko G, Domenici R, Mei E, Miano A, Marani M, Bottaro G, Spina M, Dotti M, Montanelli A, Barbato M, Viola F, Lazzari R, Vallini M, Guariso G, Plebani M, Cataldo F, Traverso G, Ventura A. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 1996; 412: 29-35 [PMID: 8783752 DOI: 10.1111/j.1651-2227.1996.tb14244.x]
3. Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med 2012; 367: 2419-2426 [PMID: 23252527 DOI: 10.1056/ NEJMcp1113994.]
4. Mäki M, Collin P. Coeliac disease. Lancet 1997; 349: 1755-1759 [PMID: 9193393 DOI: 10.1016/S0140-6736(96)70237-4]
5. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992; 102: 330-354 [PMID: 1727768]
6. Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother 2000; 54: 368-372 [PMID: 10989975 DOI: 10.1016/S0753-3322(01)80003-2.Oberhuber]
7. Bonamico M, Thanasi E, Mariani P, Nenna R, Luparia RP, Barbera C, Morra I, Lerro P, Guariso G, De Giacomo C, Scotta S, Pontone S, Carpino F, Magliocca FM. Duodenal bulb biopsies in celiac disease: a multicenter study. J Pediatr Gastroenterol Nutr 2008; 47: 618-622 [PMID: 18979585 DOI: 10.1097/MPG.0b013e3181677d6e]
8. Prasad KK, Thapa BR, Nain CK, Singh K. Assessment of the diagnostic value of duodenal bulb histology in patients with celiac disease, using multiple biopsy sites. J Clin Gastroenterol 2009; 43: 307-311 [PMID: 18827714 DOI: 10.1097/ MCG.0b013e31815b9d11]
9. Rostom A, Dubé C, Cranney A, Saloojee N, Sy R, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, Mac-Neil J, Mack D, Patel D, Moher D. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 2005; 128: S38-S46 [PMID: 15825125 DOI: 10.1053/j.gastro.2005.02.028]
10. Hill ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 2005; 128: S25-S32 [PMID: 15825123 DOI: 10.1053/j.gastro.2005.02.012]
11. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990; 65: 909-911 [PMID: 2205160 DOI: 10.1136/adc.65.8.909]
12. Mubarak A, Nikkels P, Houwen R, Ten Kate F. Reproducibility of the histological diagnosis of celiac disease. Scand J Gastroenterol 2011; 46: 1065-1073 [PMID: 21668407 DOI: 10.3109/00365521.2011.589471]
13. Mearin ML, Ivarsson A, Dickey W. Coeliac disease: is it time for mass screening? Best Pract Res Clin Gastroenterol 2005; 19: 441-452 [PMID: 15925848]
14. Baudon JJ, Johanet C, Absalon YB, Morgant G, Cabrol S, Mougenot JF. Diagnosing celiac disease: a comparison of human tissue transglutaminase antibodies with antigliadin and antiendomysium antibodies. Arch Pediatr Adolesc Med 2004; 158: 584-588 [PMID: 15184223 DOI: 10.1001/archpedi. 158.6.584]
15. Bürgin-Wolff A, Gaze H, Hadziselimovic F, Huber H, Lentze MJ, Nusslé D, Reymond-Berthet C. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child 1991; 66: 941-947 [PMID: 1819255 DOI: 10.1136/adc.66.8.941]
16. Lagerqvist C, Dahlbom I, Hansson T, Jidell E, Juto P, Olcén P, Stenlund H, Hernell O, Ivarsson A. Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age. J Pediatr Gastroenterol Nutr 2008; 47: 428-435 [PMID: 18852634 DOI: 10.1097/ MPG.0b013e31817d80f4]
17. Maglio M, Tosco A, Paparo F, Auricchio R, Granata V, Colicchio B, Indolfi V, Miele E, Troncone R. Serum and intestinal celiac disease-associated antibodies in children with celiac disease younger than 2 years of age. J Pediatr Gastroenterol Nutr 2010; 50: 43-48 [PMID: 19934769 DOI: 10.1097/ MPG.0b013e3181b99c8f]
18. Mubarak A, Gmelig-Meyling FH, Wolters VM, Ten Kate FJ, Houwen RH. Immunoglobulin G antibodies against deamidated-gliadin-peptides outperform anti-endomysium and tissue transglutaminase antibodies in children & lt; 2 years age. APMIS 2011; 119: 894-900 [PMID: 22085366 DOI: 10.1111/j.1600-0463.2011.02817.x]
19. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut 2013; 62: 43-52 [PMID: 22345659 DOI: 10.1136/ gutjnl-2011-301346]
20. Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM. Gliadin-specific, HLADQ(alpha 1*0501, beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178: 187-196 [PMID: 8315377 DOI: 10.1084/ jem.178.1.187]
21. Osman AA, Günnel T, Dietl A, Uhlig HH, Amin M, Fleckenstein B, Richter T, Mothes T. B cell epitopes of gliadin. Clin Exp Immunol 2000; 121: 248-254 [PMID: 10931138 DOI: 10.1046/j.1365-2249.2000.01312.x]
22. Vader W, Stepniak D, Kooy Y, Mearin L, Thompson A, van Rood JJ, Spaenij L, Koning F. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci USA 2003; 100: 12390-12395 [PMID: 14530392 DOI: 10.1073/pnas.2135229100]
23. Nenna R, Mora B, Megiorni F, Mazzilli MC, Magliocca FM, Tiberti C, Bonamico M. HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease. J Pediatr Gastroenterol Nutr 2008; 47: 288-292 [PMID: 18728523 DOI: 10.1097/MPG.0b013e3181615ca7]
24. Dahlbom I, Korponay-Szabó IR, Kovács JB, Szalai Z, Mäki M, Hansson T. Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase. J Pediatr Gastroenterol Nutr 2010; 50: 140-146 [PMID: 19841593 DOI: 10.1097/MPG.0b013e3181a81384]
25. Vivas S, Ruiz de Morales JG, Riestra S, Arias L, Fuentes D, Alvarez N, Calleja S, Hernando M, Herrero B, Casqueiro J, Rodrigo L. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol 2009; 15: 4775-4780 [PMID: 19824110 DOI: 10.3748/wjg.15.4775]
26. Taavela J, Kurppa K, Collin P, Lähdeaho ML, Salmi T, Saavalainen P, Haimila K, Huhtala H, Laurila K, Sievänen H, Mäki M, Kaukinen K. Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease. Clin Gastroenterol Hepatol 2013; 11: 166-71. e1 [PMID: 23063678 DOI: 10.1016/ j.cgh.2012.09.030]