Prediction of flunixin tissue residue concentrations in livers from diseased cattle

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 876-879

  Wu, H ^a   Baynes, R E ^a   Tell, L A ^b   Riviere, J E ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Flunixin; Monte Carlo simulation; Population pharmacokinetics; Tissue residue

Indexed keywords

DRUG RESIDUE; FLUNIXIN; CLONIXIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CATTLE; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG ELIMINATION; DRUG TISSUE LEVEL; LIVER METABOLISM; MONTE CARLO METHOD; PREDICTION; RESIDUE ANALYSIS; ANALOGS AND DERIVATIVES; ANIMAL; BOVINE; CHEMISTRY; FOOD CONTAMINATION; LIVER; THEORETICAL MODEL;

ANIMALIA; BOS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATTLE; CLONIXIN; FOOD CONTAMINATION; LIVER; MODELS, THEORETICAL; MONTE CARLO METHOD;

EID: 84887536941     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.10.018     Document Type: Article

References (16)

1. Bolder U., Ton-Nu H.T., Schteinqart C.D., Frick E., Hofmann A.F. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997, 112:214-225.
2. Cera, D.A., 2011. Drug Residues in Animal Derived Foods. <> (accessed 07.10.2012). http://www.fda.gov/AnimalVeterinary/ScienceResearch/ucm248790.htm.
3. Deyrup C.L., Southern K.J., Cornett J.A., Shultz C.E., Cera D.A. Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey. J. Am. Vet. Med. Assoc. 2012, 241:249-253.
4. Elmas M., Yazar E., Uney K., Karabacak A. Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits. Vet. Res. Commun. 2006, 30:73-81.
5. FOIA, 1998. Freedom of information summary: supplemental new animal drug application (NADA 101-479). <> (accessed 07.10.2012). http://www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm064905.pdf.
6. Holcomb S.S. Third-spacing: when body fluid shifts. Nursing Crit. Care 2009, 4:9-12.
7. Hwang Y., Yun H. Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats. Exp. Anim. 2011, 60:187-191.
8. Kissell, L.W., Baynes, R.E., Riviere, J.E., Smith, G.W., 2013. Occurrence of flunixin residues in bovine milk samples from the USA. Food. Addit. Contam. Part A.Chem. Anal. Control. Expo. Risk. Assess. June 21 [Epub ahead of print] doi:10.1080/19440049.2013.803604.
9. Kopcha M., Ahl A.S. Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals. J. Am. Vet. Med. Assoc. 1989, 194:45-49.
10. Landoni M.F., Cunningham F.M., Lees P. Determination of pharmacokinetics and pharmacodynamics of flunixin in calves by use of pharmacokinetic/pharmacodynamics modeling. Am. J. Vet. Res. 1995, 56:786-794.
11. Monshouwer M., Witkamp R.F. Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini review. Vet. Quart. 2000, 22:17-20.
12. Rao G.S., Ramesh S., Ahmad A.H., Tripathi H.C., Sharma L.D., Malik J.K. Effects of endotoxin-induced fever and probenecid on disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administration of enrofloxacin in goats. J. Vet. Pharmacol. Ther. 2000, 23:365-372.
13. Sarwari A.R., Mackowiak P.A. The pharmacologic consequences of fever. Infect. Dis. Clin. North. Am. 1996, 10:21-32.
14. US Department of Agriculture, 2009. Food Safety Inspection Service. <> (accessed 07.10.2012). http://www.fsis.usda.gov/PDF/2009_Red_Book.pdf.
15. US Department of Agriculture, 2010. Food Safety Inspection Service. <> (accessed 07.10.2012). http://www.fsis.usda.gov/PDF/2010_Red_Book.pdf.
16. Wu H., Baynes R.E., Leavens T., Tell L.A., Riviere J.E. Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle. J. Vet. Pharmacol. Ther. 2012, 36:248-257.