Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle

Journal of Veterinary Pharmacology and Therapeutics

Volumn 36, Issue 3, 2013, Pages 248-257

  Wu, H ^a   Baynes, R E ^a   Leavens, T ^a   Tell, L A ^b   Riviere, J E ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUNIXIN; CLONIXIN; DRUG RESIDUE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL TISSUE; ARTICLE; CATTLE; DRUG ABSORPTION; DRUG ELIMINATION; LIVER; MALE; MONTE CARLO METHOD; NONHUMAN; POPULATION MODEL; PRIORITY JOURNAL; ALGORITHM; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BLOOD; BOVINAE; COMPUTER SIMULATION; DRUG ADMINISTRATION ROUTE; FEMALE; METABOLISM;

ANIMALIA; BOS;

ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATTLE; CLONIXIN; COMPUTER SIMULATION; DRUG ADMINISTRATION ROUTES; DRUG RESIDUES; FEMALE; LIVER; MALE; MODELS, BIOLOGICAL; MONTE CARLO METHOD;

EID: 84877637829     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2012.01420.x     Document Type: Article

References (33)

1. Anderson, K.L., Neff-Davis, C.A., Davis, L.E. & Bass, V.D. (1990) Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations. American Journal of Veterinary Research, 51, 1464-1467.
2. Baynes, R.E., Payne, M., Martin-Jimenez, T., Abdullah, A., Anderson, K.L., Webb, A.I., Craigmill, A. & Riviere, J.E. (2000) Extralabel use of ivermecin and moxidectin in food animals. Journal of the American Veterinary Medical Association, 217, 668-671.
3. Buur, J.L., Baynes, R.E., Smith, G. & Riviere, J.E. (2006a) Pharmacokinetics of flunixin meglumine in swine after intravenous dosing. Journal of Veterinary Pharmacology and Therapeutics, 29, 437-440.
4. Buur, J., Baynes, R., Smith, G. & Riviere, J. (2006b) Use of probilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine. Antimicrobial Agents and Chemotherapy, 50, 2344-2351.
5. Cameron, B.D., Done, J.N. & Young, W.B. (1985) The pharmacokinetics of flunixin (Finadyne) in the plasma and milk of lactating cows: a comparison between formulations. European Association for Veterinary Pharmacology and Toxicology, 3rd Cong, 88
6. Clement, R.P., Simmons, R.D., Christopher, R.J., Charles, S.F., Casciano, C.N., McCullough, C.B., Lamendola, J.F. & Cayen, M.N. (1992) Design and conduct of studies to meet residue chemistry requirements; residue depletion and metabolism of flunixin in cattle. In Xenobiotics and Food-Producing Animals. Eds Hutson, D.H., Hawkins, D.R., Paulson, G.D. & Struble, C.B., pp. 37-49. American Chemical Society, Washington, DC.
7. Concordet, D. & Toutain, P.L. (1997) The withdrawal time estimation of veterinary drugs: a nonparametric approach. Journal of Veterinary Pharmacology and Therapeutics, 20, 374-379.
8. Duan, J.Z. (2007) Applications of population pharmacokinetics in current drug labelling. Journal of Clinical Pharmacy and Therapeutics, 32, 57-59.
9. Elmas, M., Yazar, E., Uney, K. & Karabacak, A. (2006) Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits. Veterinary Research Communications, 30, 73-81.
10. Ette, E. (1997) Stability and performance of a population pharmacokinetic model. Journal of Clinical Pharmacology, 37, 486-495.
11. FDA. (June 21, 2005) U.S. Department of Agriculture, Food and Drug Administration (FDA). Guidance for industry no. 3: general principles for evaluation the safety of compounds used in food producing animals. [Online] http://www.fda.gov/downloads/animalveterinary/guidancecomplianceenforcement/guidanceforindustry/ucm052180.pdf.
12. FDA. (2007) FARAD newsletter. Issue#9 2007.
13. FOIA. (1998) Freedom of information summary: supplemental new animal drug application (NADA 101-479). http://www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm064905.pdf
14. Hannon, S.J., Perrett, T., Wildman, B.K., Schunicht, O.C., Vogstad, A.R., Fenton, R.K., Burciaga-Robles, L.O., Pollock, C.M., Jim, G.K., Berg, J. & Booker, C.W. (2009) Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves. Veterinary Therapeutics, 10, E1-E18.
15. Hardee, G.E., Smith, J.A. & Harris, S.J. (1985) Pharmacokinetics of flunixin meglumine in the cow. Research in Veterinary Science, 39, 110-112.
16. Hwang, Y. & Yun, H. (2011) Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats. Experimental Animals, 60, 187-191.
17. Johansson, M. & Anler, E.L. (1988) Gas chromatographic analysis of flunixin in equine urine after extractive methylation. Journal of Chromatography, 427, 55-66.
18. Landoni, M.F., Cunningham, F.M. & Lees, P. (1995) Determination of pharmacokinetics and pharmacodynamics of flunixin in calves by use of pharmacokinetic/pharmacodynamics modeling. American Journal of Veterinary Research, 56, 786-794.
19. Lees, P. & Higgins, A.J. (1984) Flunixin inhibits prostaglandin E2 production in equine inflammation. Research in Veterinary Science, 37, 347-349.
20. Lichtenwalner, D.M., Cameron, B.D. & Young, C. (1986) The metabolism and pharmacokinetics of flunixin in cows and steers. 14th World Congress on Diseases of Cattle, 14, 1179-1183.
21. Maclachlan, D.J. (2009) Influence of physiological status on residues of lipophilic xenobiotics in livestock. Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 26, 697-712.
22. Martin-Jimenez, T. & Riviere, J.E. (1998) Population pharmacokinetics in veterinary medicine: potential use for therapeutic drug monitoring and prediction of tissue residues. Journal of Veterinary Pharmacology and Therapeutics, 21, 167-189.
23. Monshouwer, M. & Witkamp, R.F. (2000) Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini review. The Veterinary Quarterly, 22, 17-20.
24. Odensvik, K. (1995) Pharmacokinetics of flunixin and its effect on prostaglandin F2alpha metabolite concentrations after oral and intravenous administration in heifers. Journal of Veterinary Pharmacology and Therapeutics, 18, 254-259.
25. Odensvik, K. & Johansson, I.M. (1995) High-performance liquid chromatography method for determination of flunixin in bovine pharmacokinetics after single and repeated doses of the drug. American Journal of Veterinary Research, 56, 489-495.
26. Rantala, M., Kaartinen, L., Valimaki, E., Stryrman, M., Hiekkaranta, M., Niemi, A., Saari, L. & Pyorala, S. (2002) Efficacy and pharmacokinetics of enrofloxacin and flunixin megumine for treatment of cows with experimentally induced Escherichia coli Mastitis. Journal of Veterinary Pharmacology and Therapeutics, 25, 251-258.
27. Rao, G.S., Ramesh, S., Ahmad, A.H., Tripathi, H.C., Sharma, L.D. & Malik, J.K. (2000) Effects of endotoxin-induced fever and probenecid on disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administration of enrofloxacin in goats. Journal of Veterinary Pharmacology and Therapeutics, 23, 365-372.
28. Sarwari, A.R. & Mackowiak, P.A. (1996) The pharmacologic consequences of fever. Infectious Disease Clinics of North America, 10, 21-32.
29. Sheiner, L.B., Rosenberg, B. & Marathe, V.V. (1977) Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. Journal of Pharmacokinetics and Biopharmaceutics, 5, 445-479.
30. Smith, G.F., Davis, J.L., Tell, L.A., Webb, A.I. & Riviere, J.E. (2008) Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. Journal of the American Veterinary Medical Association, 22, 697-701.
31. USDA FSIS (2007) U.S. Department of Agriculture, Food Safety Inspection Service, p. 3. http://www.fsis.usda.gov/PDF/2007_Red_Book_Complete.pdf
32. USDA FSIS (2008) U.S. Department of Agriculture, Food Safety Inspection Service, p. 7. http://www.fsis.usda.gov/PDF/2008_Red_Book.pdf .
33. Vane, J.R. & Botting, J.H. & Botting, R.M. (1996) Overview-mechanism of action of anti-inflammatory drugs. In Improved Non-steroid Anti-inflammatory Drugs. COX-2 Enzyme Inhibitors. Eds Vane, J.R., Botting, J.H. & Botting, R.M., pp. 1-27. Kluwer Academic Publishers and William Harvey Press, London.