메뉴 건너뛰기




Volumn 10, Issue , 2013, Pages

Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo

Author keywords

Experimental autoimmune encephalomyelitis (EAE); Molecular imaging; Near infrared fluorescence; Protease

Indexed keywords

CATHEPSIN B; DIAGNOSTIC AGENT; NANOPARTICLE; NEAR INFRARED IMAGING AGENT; POLYGLACTIN; UNCLASSIFIED DRUG;

EID: 84887520916     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-138     Document Type: Article
Times cited : (24)

References (47)
  • 1
    • 80053300497 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
    • 10.1111/j.1476-5381.2011.01302.x, 3229753, 21371012
    • Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol 2011, 164:1079-1106. 10.1111/j.1476-5381.2011.01302.x, 3229753, 21371012.
    • (2011) Br J Pharmacol , vol.164 , pp. 1079-1106
    • Constantinescu, C.S.1    Farooqi, N.2    O'Brien, K.3    Gran, B.4
  • 2
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • 10.1093/brain/awl075, 16632554
    • Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129:1953-1971. 10.1093/brain/awl075, 16632554.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 3
    • 0035554898 scopus 로고    scopus 로고
    • Multiple sclerosis: a two-stage disease
    • 10.1038/ni0901-762, 11526378
    • Steinman L. Multiple sclerosis: a two-stage disease. Nat Immunol 2001, 2:762-764. 10.1038/ni0901-762, 11526378.
    • (2001) Nat Immunol , vol.2 , pp. 762-764
    • Steinman, L.1
  • 4
    • 84884281404 scopus 로고    scopus 로고
    • Using EAE to better understand principles of immune function and autoimmune pathology
    • Rangachari M, Kuchroo VK. Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun 2013, http://dx.doi.org/10.1016/j.jaut.2013.1006.1008.
    • (2013) J Autoimmun
    • Rangachari, M.1    Kuchroo, V.K.2
  • 5
    • 0022468240 scopus 로고
    • Dissociation between histological and clinical signs of experimental auto-immune encephalomyelitis
    • Kallen B, Nilsson O. Dissociation between histological and clinical signs of experimental auto-immune encephalomyelitis. Acta Pathol, Microbiol, et Immunol Scand - Sec A, Pathol 1986, 94:159-164.
    • (1986) Acta Pathol, Microbiol, et Immunol Scand - Sec A, Pathol , vol.94 , pp. 159-164
    • Kallen, B.1    Nilsson, O.2
  • 7
    • 84875325750 scopus 로고    scopus 로고
    • Murine whole-organ immune cell populations revealed by multi-epitope-ligand cartography
    • 10.1369/0022155412470140, 23160665
    • Eckhardt J, Ostalecki C, Kuczera K, Schuler G, Pommer AJ, Lechmann M. Murine whole-organ immune cell populations revealed by multi-epitope-ligand cartography. J Histochem Cytochem 2013, 61:125-133. 10.1369/0022155412470140, 23160665.
    • (2013) J Histochem Cytochem , vol.61 , pp. 125-133
    • Eckhardt, J.1    Ostalecki, C.2    Kuczera, K.3    Schuler, G.4    Pommer, A.J.5    Lechmann, M.6
  • 8
    • 84873709408 scopus 로고    scopus 로고
    • Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels
    • Paul D, Cowan AE, Ge S, Pachter JS. Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. Microvasc Res 2013, 86:1-10.
    • (2013) Microvasc Res , vol.86 , pp. 1-10
    • Paul, D.1    Cowan, A.E.2    Ge, S.3    Pachter, J.S.4
  • 9
    • 80054862353 scopus 로고    scopus 로고
    • Paranodal myelin retraction in relapsing experimental autoimmune encephalomyelitis visualized by coherent anti-Stokes Raman scattering microscopy
    • 10.1117/1.3638180, 3206924, 22029353
    • Fu Y, Frederick TJ, Huff TB, Goings GE, Miller SD, Cheng JX. Paranodal myelin retraction in relapsing experimental autoimmune encephalomyelitis visualized by coherent anti-Stokes Raman scattering microscopy. J Biomed Opt 2011, 16:106006. 10.1117/1.3638180, 3206924, 22029353.
    • (2011) J Biomed Opt , vol.16 , pp. 106006
    • Fu, Y.1    Frederick, T.J.2    Huff, T.B.3    Goings, G.E.4    Miller, S.D.5    Cheng, J.X.6
  • 10
    • 33846928866 scopus 로고    scopus 로고
    • Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis
    • 10.1073/pnas.0610544104, 1783904, 17261805
    • Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2007, 104:1937-1942. 10.1073/pnas.0610544104, 1783904, 17261805.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1937-1942
    • Radu, C.G.1    Shu, C.J.2    Shelly, S.M.3    Phelps, M.E.4    Witte, O.N.5
  • 11
    • 84860157822 scopus 로고    scopus 로고
    • Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [(1)(8)F]DPA-714
    • 10.1523/JNEUROSCI.2900-11.2012, 22539835
    • Abourbeh G, Theze B, Maroy R, Dubois A, Brulon V, Fontyn Y, Dolle F, Tavitian B, Boisgard R. Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [(1)(8)F]DPA-714. J Neurosci 2012, 32:5728-5736. 10.1523/JNEUROSCI.2900-11.2012, 22539835.
    • (2012) J Neurosci , vol.32 , pp. 5728-5736
    • Abourbeh, G.1    Theze, B.2    Maroy, R.3    Dubois, A.4    Brulon, V.5    Fontyn, Y.6    Dolle, F.7    Tavitian, B.8    Boisgard, R.9
  • 12
    • 0001710321 scopus 로고    scopus 로고
    • MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS)
    • Barkhof F. MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS). Mult Scler 1999, 5:283-286.
    • (1999) Mult Scler , vol.5 , pp. 283-286
    • Barkhof, F.1
  • 13
    • 41849109453 scopus 로고    scopus 로고
    • Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis
    • 10.1093/brain/awn004, 18234693
    • Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain 2008, 131:1123-1133. 10.1093/brain/awn004, 18234693.
    • (2008) Brain , vol.131 , pp. 1123-1133
    • Chen, J.W.1    Breckwoldt, M.O.2    Aikawa, E.3    Chiang, G.4    Weissleder, R.5
  • 14
    • 82655181352 scopus 로고    scopus 로고
    • VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis
    • 10.1096/fj.11-183772, 3394669, 21908714
    • Serres S, Mardiguian S, Campbell SJ, McAteer MA, Akhtar A, Krapitchev A, Choudhury RP, Anthony DC, Sibson NR. VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis. FASEB J 2011, 25:4415-4422. 10.1096/fj.11-183772, 3394669, 21908714.
    • (2011) FASEB J , vol.25 , pp. 4415-4422
    • Serres, S.1    Mardiguian, S.2    Campbell, S.J.3    McAteer, M.A.4    Akhtar, A.5    Krapitchev, A.6    Choudhury, R.P.7    Anthony, D.C.8    Sibson, N.R.9
  • 15
    • 41049089072 scopus 로고    scopus 로고
    • Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease
    • 10.1186/1742-2094-5-6, 2267451, 18237444
    • Luo J, Ho P, Steinman L, Wyss-Coray T. Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease. J Neuroinflammation 2008, 5:6. 10.1186/1742-2094-5-6, 2267451, 18237444.
    • (2008) J Neuroinflammation , vol.5 , pp. 6
    • Luo, J.1    Ho, P.2    Steinman, L.3    Wyss-Coray, T.4
  • 16
    • 79951838515 scopus 로고    scopus 로고
    • Longitudinal near-infrared imaging of myelination
    • 10.1523/JNEUROSCI.2698-10.2011, 3044505, 21325505
    • Wang C, Wu C, Popescu DC, Zhu J, Macklin WB, Miller RH, Wang Y. Longitudinal near-infrared imaging of myelination. J Neurosci 2011, 31:2382-2390. 10.1523/JNEUROSCI.2698-10.2011, 3044505, 21325505.
    • (2011) J Neurosci , vol.31 , pp. 2382-2390
    • Wang, C.1    Wu, C.2    Popescu, D.C.3    Zhu, J.4    Macklin, W.B.5    Miller, R.H.6    Wang, Y.7
  • 17
    • 0001273549 scopus 로고    scopus 로고
    • Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation
    • 10.1364/OL.26.000893, 18040483
    • Ntziachristos V, Weissleder R. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett 2001, 26:893-895. 10.1364/OL.26.000893, 18040483.
    • (2001) Opt Lett , vol.26 , pp. 893-895
    • Ntziachristos, V.1    Weissleder, R.2
  • 18
    • 1942454913 scopus 로고    scopus 로고
    • Experimental fluorescence tomography of tissues with noncontact measurements
    • 10.1109/TMI.2004.825633, 15084074
    • Schulz RB, Ripoll J, Ntziachristos V. Experimental fluorescence tomography of tissues with noncontact measurements. IEEE Trans Med Imaging 2004, 23:492-500. 10.1109/TMI.2004.825633, 15084074.
    • (2004) IEEE Trans Med Imaging , vol.23 , pp. 492-500
    • Schulz, R.B.1    Ripoll, J.2    Ntziachristos, V.3
  • 19
    • 70349251400 scopus 로고    scopus 로고
    • Compensation of optical heterogeneity-induced artifacts in fluorescence molecular tomography: theory and in vivo validation
    • 10.1117/1.3149855, 19566314
    • Mohajerani P, Adibi A, Kempner J, Yared W. Compensation of optical heterogeneity-induced artifacts in fluorescence molecular tomography: theory and in vivo validation. J Biomed Opt 2009, 14:034021. 10.1117/1.3149855, 19566314.
    • (2009) J Biomed Opt , vol.14 , pp. 034021
    • Mohajerani, P.1    Adibi, A.2    Kempner, J.3    Yared, W.4
  • 21
    • 33748308883 scopus 로고    scopus 로고
    • Targeting proteases: successes, failures and future prospects
    • 10.1038/nrd2092, 16955069
    • Turk B. Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 2006, 5:785-799. 10.1038/nrd2092, 16955069.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 785-799
    • Turk, B.1
  • 22
    • 33846164404 scopus 로고    scopus 로고
    • Emerging roles of cysteine cathepsins in disease and their potential as drug targets
    • 10.2174/138161207780162962, 17311556
    • Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des 2007, 13:387-403. 10.2174/138161207780162962, 17311556.
    • (2007) Curr Pharm Des , vol.13 , pp. 387-403
    • Vasiljeva, O.1    Reinheckel, T.2    Peters, C.3    Turk, D.4    Turk, V.5    Turk, B.6
  • 23
    • 34748859681 scopus 로고    scopus 로고
    • The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    • 10.1124/pr.59.3.3, 2034302, 17878513
    • Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007, 59:251-287. 10.1124/pr.59.3.3, 2034302, 17878513.
    • (2007) Pharmacol Rev , vol.59 , pp. 251-287
    • Kobori, H.1    Nangaku, M.2    Navar, L.G.3    Nishiyama, A.4
  • 24
    • 0036737795 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation
    • 10.1002/glia.10108, 12203394
    • Rosenberg GA. Matrix metalloproteinases in neuroinflammation. Glia 2002, 39:279-291. 10.1002/glia.10108, 12203394.
    • (2002) Glia , vol.39 , pp. 279-291
    • Rosenberg, G.A.1
  • 25
    • 0029004145 scopus 로고
    • Increased cathepsin B activity in multiple sclerosis brain
    • 10.1016/0022-510X(95)00039-5, 7561950
    • Bever CT, Garver DW. Increased cathepsin B activity in multiple sclerosis brain. J Neurol Sci 1995, 131:71-73. 10.1016/0022-510X(95)00039-5, 7561950.
    • (1995) J Neurol Sci , vol.131 , pp. 71-73
    • Bever, C.T.1    Garver, D.W.2
  • 26
    • 80054899016 scopus 로고    scopus 로고
    • Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis
    • 10.1111/j.1582-4934.2010.01229.x, 21143385
    • Haves-Zburof D, Paperna T, Gour-Lavie A, Mandel I, Glass-Marmor L, Miller A. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. J Cell Mol Med 2011, 15:2421-2429. 10.1111/j.1582-4934.2010.01229.x, 21143385.
    • (2011) J Cell Mol Med , vol.15 , pp. 2421-2429
    • Haves-Zburof, D.1    Paperna, T.2    Gour-Lavie, A.3    Mandel, I.4    Glass-Marmor, L.5    Miller, A.6
  • 29
    • 78650185098 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE
    • 10.1016/j.jneuroim.2010.08.011, 20832870
    • Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA, McQuaid S. Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J Neuroimmunol 2010, 229:180-191. 10.1016/j.jneuroim.2010.08.011, 20832870.
    • (2010) J Neuroimmunol , vol.229 , pp. 180-191
    • Bennett, J.1    Basivireddy, J.2    Kollar, A.3    Biron, K.E.4    Reickmann, P.5    Jefferies, W.A.6    McQuaid, S.7
  • 30
    • 79960134214 scopus 로고    scopus 로고
    • Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents
    • 10.1158/1535-7163.MCT-11-0008, 21586628
    • Zhang Q, Bindokas V, Shen J, Fan H, Hoffman RM, Xing HR. Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents. Mol Cancer Ther 2011, 10:1173-1184. 10.1158/1535-7163.MCT-11-0008, 21586628.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1173-1184
    • Zhang, Q.1    Bindokas, V.2    Shen, J.3    Fan, H.4    Hoffman, R.M.5    Xing, H.R.6
  • 32
    • 0032697682 scopus 로고    scopus 로고
    • Near-infrared optical imaging of protease activity for tumor detection
    • 10.1148/radiology.213.3.r99dc14866, 10580968
    • Mahmood U, Tung CH, Bogdanov A, Weissleder R. Near-infrared optical imaging of protease activity for tumor detection. Radiology 1999, 213:866-870. 10.1148/radiology.213.3.r99dc14866, 10580968.
    • (1999) Radiology , vol.213 , pp. 866-870
    • Mahmood, U.1    Tung, C.H.2    Bogdanov, A.3    Weissleder, R.4
  • 33
    • 0032951071 scopus 로고    scopus 로고
    • In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    • 10.1038/7933, 10207887
    • Weissleder R, Tung CH, Mahmood U, Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17:375-378. 10.1038/7933, 10207887.
    • (1999) Nat Biotechnol , vol.17 , pp. 375-378
    • Weissleder, R.1    Tung, C.H.2    Mahmood, U.3    Bogdanov, A.4
  • 34
    • 0034760321 scopus 로고    scopus 로고
    • Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model
    • 10.1148/radiol.2212010368, 11687699
    • Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH. Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology 2001, 221:523-529. 10.1148/radiol.2212010368, 11687699.
    • (2001) Radiology , vol.221 , pp. 523-529
    • Bremer, C.1    Bredow, S.2    Mahmood, U.3    Weissleder, R.4    Tung, C.H.5
  • 36
    • 66749152769 scopus 로고    scopus 로고
    • Noninvasive quantitative tomography of the therapeutic response to dexamethasone in ovalbumin-induced murine asthma
    • 10.1124/jpet.108.147579, 19293392
    • Korideck H, Peterson JD. Noninvasive quantitative tomography of the therapeutic response to dexamethasone in ovalbumin-induced murine asthma. J Pharmacol Exp Ther 2009, 329:882-889. 10.1124/jpet.108.147579, 19293392.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 882-889
    • Korideck, H.1    Peterson, J.D.2
  • 38
    • 33746223025 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo
    • 10.1161/CIRCULATIONAHA.106.619056, 16801460
    • Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 2006, 114:55-62. 10.1161/CIRCULATIONAHA.106.619056, 16801460.
    • (2006) Circulation , vol.114 , pp. 55-62
    • Deguchi, J.O.1    Aikawa, M.2    Tung, C.H.3    Aikawa, E.4    Kim, D.E.5    Ntziachristos, V.6    Weissleder, R.7    Libby, P.8
  • 41
    • 77952687414 scopus 로고    scopus 로고
    • Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis
    • 10.1186/ar3038, 2911895, 20509880
    • Peterson JD, Labranche TP, Vasquez KO, Kossodo S, Melton M, Rader R, Listello JT, Abrams MA, Misko TP. Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis. Arthritis Res Ther 2010, 12:R105. 10.1186/ar3038, 2911895, 20509880.
    • (2010) Arthritis Res Ther , vol.12
    • Peterson, J.D.1    Labranche, T.P.2    Vasquez, K.O.3    Kossodo, S.4    Melton, M.5    Rader, R.6    Listello, J.T.7    Abrams, M.A.8    Misko, T.P.9
  • 42
    • 0025310390 scopus 로고
    • Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction
    • Kennedy MK, Tan LJ, Miller SD, Dal Canto MC. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. J Immunol 1990, 145:117-126.
    • (1990) J Immunol , vol.145 , pp. 117-126
    • Kennedy, M.K.1    Tan, L.J.2    Miller, S.D.3    Dal Canto, M.C.4
  • 43
    • 0025990276 scopus 로고
    • Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance
    • Tan LJ, Kennedy MK, Dal Canto MC, Miller SD. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J Immunol 1991, 147:1797-1802.
    • (1991) J Immunol , vol.147 , pp. 1797-1802
    • Tan, L.J.1    Kennedy, M.K.2    Dal Canto, M.C.3    Miller, S.D.4
  • 44
    • 0026557522 scopus 로고
    • Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition
    • Tan LJ, Kennedy MK, Miller SD. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J Immunol 1992, 148:2748-2755.
    • (1992) J Immunol , vol.148 , pp. 2748-2755
    • Tan, L.J.1    Kennedy, M.K.2    Miller, S.D.3
  • 45
    • 80052670800 scopus 로고    scopus 로고
    • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells
    • 10.4049/jimmunol.1004175, 3159828, 21821796
    • Getts DR, Turley DM, Smith CE, Harp CT, McCarthy D, Feeney EM, Getts MT, Martin AJ, Luo X, Terry RL, King NJ, Miller SD. Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. J Immunol 2011, 187:2405-2417. 10.4049/jimmunol.1004175, 3159828, 21821796.
    • (2011) J Immunol , vol.187 , pp. 2405-2417
    • Getts, D.R.1    Turley, D.M.2    Smith, C.E.3    Harp, C.T.4    McCarthy, D.5    Feeney, E.M.6    Getts, M.T.7    Martin, A.J.8    Luo, X.9    Terry, R.L.10    King, N.J.11    Miller, S.D.12
  • 46
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • 10.1084/jem.182.1.75, 2192093, 7540658
    • McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med 1995, 182:75-85. 10.1084/jem.182.1.75, 2192093, 7540658.
    • (1995) J Exp Med , vol.182 , pp. 75-85
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 47
    • 0034650422 scopus 로고    scopus 로고
    • Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis
    • Vanderlugt CL, Eagar TN, Neville KL, Nikcevich KM, Bluestone JA, Miller SD. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. J Immunol 2000, 164:670-678.
    • (2000) J Immunol , vol.164 , pp. 670-678
    • Vanderlugt, C.L.1    Eagar, T.N.2    Neville, K.L.3    Nikcevich, K.M.4    Bluestone, J.A.5    Miller, S.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.