Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32160-32171

  Ugolev, Yelena ^a   Segal, Tali ^a   Yaffe, Dana ^a   Gros, Yael ^a   Schuldiner, Shimon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; DIRECTED MUTAGENESIS; HUNTINGTON DISEASE; MAJOR FACILITATOR SUPERFAMILY; MULTIDRUG TRANSPORTERS; RANDOM MUTAGENESIS; RECOGNITION SITE; SUBSTRATE TRANSPORTS;

AMINO ACIDS; MUTAGENESIS;

DIGITAL STORAGE;

GLYCINE; PROLINE; PROTEOLIPOSOME; PROTON; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORTER 2;

ALPHA HELIX; ARTICLE; CHEMICAL INTERACTION; CONFORMATION; CONFORMATIONAL REARRANGEMENT; CONTROLLED STUDY; DRUG MECHANISM; FUNGAL STRAIN; FUNGUS GROWTH; GENETIC TRANSFECTION; MUTAGENESIS; MUTANT; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN DETERMINATION; SACCHAROMYCES CEREVISIAE;

DIRECTED EVOLUTION; ION-COUPLED TRANSPORTERS; MEMBRANE PROTEINS; MFS SUPERFAMILY; MULTIDRUG TRANSPORTERS; NEUROTRANSMITTER TRANSPORT; NEUROTRANSMITTERS; PXXP MOTIFS;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RATS; SACCHAROMYCES CEREVISIAE; TETRABENAZINE; TOURETTE SYNDROME; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84887491306     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.502971     Document Type: Article

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