Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification

Frontiers in Molecular Neuroscience

Volumn 3, Issue MAR, 2010, Pages

  Madry, Christian ^a   Betz, Heinrich ^a   Geiger, Jörg R P ^a   Laube, Bodo ^b  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Excitatory glycine receptor; Ligand binding domain; NMDA receptor; NR1 antagonist; NR3 subunit; Supralinear potentiation; Voltage block; Zn2+

Indexed keywords

EID: 84887456738     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2010.00006     Document Type: Article

References (38)

1. Armstrong, N., and Gouaux, E. (2000). Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28, 165-181.
2. Awobuluyi, M., Yang, J., Ye, Y., Chatterton, J. E., Godzik, A., Lipton, S. A., and Zhang, D. (2007). Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-Daspartate receptors. Mol. Pharmacol. 71, 112-122.
3. Betz, H., and Laube, B. (2006). Glycine receptors: recent insights into their structural organization and functional diversity. J. Neurochem. 97, 1600-1610.
4. Chatterton, J. E., Awobuluyi, M., Premkumar, L. S., Takahashi, H., Talantova, M., Shin, Y., Cui, J., Tu, S., Sevarino, K. A., Nakanishi, N., Tong, G., Lipton, S. A., and Zhang, D. (2002). Excitatory glycine receptors containing the NR3 familiy of NMDA receptor subunits. Nature 415, 793-797.
5. Cull-Candy, S., Brickley, S., and Farrant, M. (2001). NMDA receptor subunits: Diversity, development and disease. Curr. Opin. Neurobiol. 11, 327-335.
6. Dingledine, R., Borges, K., Bowie, D., and Traynelis, S. F. (1999). The glutamate receptor ion channels. Pharmacol. Rev. 51, 7-61.
7. Frederickson, C. J., Koh, J. Y., and Bush, A. I. (2005). The neurobiology of zinc in health and disease. Nat. Rev. Neurosci. 6, 449-462.
8. Furukawa, H., Singh, S. K., Mancusso, R., and Gouaux, E. (2005). Subunit arrangement and function in NMDA receptors. Nature 438, 185-192.
9. + permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15, 193-204.
10. Grudzinska, J., Schemm, R., Haeger, S., Nicke, A., Schmalzing, G., Betz, H., and Laube, B. (2005). The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45, 727-739.
11. + as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52, 679-690.
12. Johnson, J. W., and Ascher, P. (1987). Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325, 529-531.
13. Katz, E., Verbitsky, M., Rothlin, C., Vetter, D., Heinemann, S. F., and Elgoyhen, A. (2000). High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor. Hear. Res. 141, 117-128.
14. Kuner, T., Wollmuth, L. P., Karlin, A., Seeburg, P. H., and Sakmann, B. (1996). Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron 17, 343-352.
15. Kuryatov, A., Laube, B., Betz, H., and Kuhse, J. (1994). Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron 12, 1291-1300.
16. Laube, B., Hirai, H., Sturgess, M., Betz, H., and Kuhse, J. (1997). Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron 18, 493-503.
17. Laube, B., Kuhse, J., and Betz, H. (1998). Evidence for a tetrameric structure of recombinant NMDA receptors. J. Neurosci. 18, 2954-2961.
18. Laube, B., Kuhse, J., Rundstrom, N., Kirsch, J., Schmieden, V., and Betz, H. (1995).Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. J. Physiol. 483, 613-619.
19. Laube, B., Schemm, R., and Betz, H. (2004). Molecular determinants of ligand discrimination in the glutamatebinding pocket of the NMDA receptor. Neuropharmacology 47, 994-1007.
20. + and NR1-site antagonist. Proc. Natl. Acad. Sci. U.S.A. 105, 12563-12568.
21. Madry, C., Mesic, I., Bartholomäus, I., Nicke, A., Betz, H., and Laube, B. (2007a). Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function. Biochem. Biophys. Res. Commun. 354, 102-108.
22. + inhibition and glycine affinity of NMDA receptors. Mol. Pharmacol. 72, 1535-1544.
23. Mayer, M. L. (2006). Glutamate receptors at atomic resolution. Nature 440, 456-462.
24. Nishi, M., Hinds, H., Lu, H. P., Kawata, M., and Hayashi, Y. (2001). Motoneuronspecific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. J. Neurosci. 21, RC185.
25. Parnas, M., Katz, B., Lev, S., Tzarfaty, V., Dadon, D., Gordon-Shaag, A., Metzner, H., Yaka, R., and Minke, B. (2009). Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J. Neurosci. 29, 2371-2383.
26. Rosenmund, C., Stern-Bach, Y., and Stevens, C. F. (1998). The tetrameric structure of a glutamate receptor channel. Science 280, 1596-1599.
27. Schüler, T., Mesic, I., Madry, C., Bartholomäus, I., and Laube, B. (2008). Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. J. Biol. Chem. 283, 37-46.
28. Smothers, C. T., and Woodward, J. J. (2009). Expression of glycine-activated diheteromeric NR1/NR3 receptors in HEK293 cells is NR1 splice variant dependent. J. Pharmacol. Exp. Ther. 331, 975-984.
29. Sucher, N. J., Akbarian, S., Chi, C. L., Leclerc, C. L., Awobuluyi, M., Deitcher, D. L., Wu, M. K., Yuan, J. P., Jones, E. G., and Lipton, S. A. (1995). Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J. Neurosci. 15, 6509-6520.
30. Tong, G., Takahashi, H., Tu, S., Shin, Y., Talantova, M., Zago, W., Xia, P., Nie, Z., Goetz, T., Zhang, D., Lipton, S. A., and Nakanishi, N. (2008). Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. J. Neurophysiol. 99, 122-132.
31. Ulbrich, M. H., and Isacoff, E. Y. (2008). Rules of engagement for NMDA receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 105, 14163-14168.
32. Wada, A., Takahashi, H., Lipton, S., and Chen, V. (2006). NR3A modulates the outer vestibule of the 'NMDA' receptor channel. J. Neurosci. 26, 13156-13166.
33. + flux rates in NMDA receptor channels. J. Neurosci. 22, 10209-10216.
34. Weisstaub, N., Vetter, D., Elgoyhen, A., and Katz, E. (2002). The α9α10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations. Hear. Res. 167, 122-135.
35. +. Mol. Pharmacol. 53, 933-941.
36. Wong, E. H., Kemp, J. A., Priestley, T., Knight, A. R., Woodruff, G. N., and Iversen, L. L. (1986). The anticonvulsant MK-801 is a potent N-methyl-Daspartate antagonist. Proc. Natl. Acad. Sci. U.S.A. 83, 7104-7108.
37. Yao, Y., and Mayer, M. L. (2006). Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. J. Neurosci. 26, 4559-4566.
38. Yuan, H., Erreger, K., Dravid, S. M., and Traynelis, S. F. (2005). Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. J. Biol. Chem. 280, 29708-29716.