Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 34, 2008, Pages 12563-12568

  Madry, Christian ^a   Betz, Heinrich ^a   Geiger, Jörg R P ^a   Laube, Bodo ^b  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Binding site; Ligand gated ion channel; NMDA receptor; Zinc

Indexed keywords

GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1 ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 3A; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; FEMALE; LIGAND BINDING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING;

ANIMALS; BINDING SITES; ELECTROPHYSIOLOGY; GLYCINE; MICROINJECTIONS; MUTATION; OOCYTES; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; RNA; XENOPUS LAEVIS; ZINC;

EID: 50449105436     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805624105     Document Type: Article

References (36)

1. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
2. Collingridge GL, Bliss TV (1995) Memories of NMDA receptors and LTP. Trends Neurosci 18:54-56.
3. Cull-Candy SG, Leszkiewicz DN (2004) Role of distinct NMDA receptor subtypes at central synapses. Sci STKE (255):re16.
4. Madden DR (2002) The structure and function of glutamate receptor ion channels. Nat Rev 3:91-101.
5. Laube B, Kuhse J, Betz H (1998) Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci 18:2954-2961.
6. Johnson JW, Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325:529-531.
7. Das S, et al. (1998) Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393:377-381.
8. Perez-Otano I, et al. (2001) Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci 21:1228-1237.
9. Matsuda K, Fletcher M, Kamiya Y, Yuzaki M (2003) Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors. J Neurosci 5:10064-10073.
10. Tong G, et al. (2008) Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. J Neurophysiol 99:122-132.
11. Schüler T, Mesic I, Madry C, Bartholomäus I, Laube B (2008) Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. J Biol Chem 283:37-46.
12. Chatterton JE, et al. (2002) Excitatory glycine receptors containing the NR3 familiy of NMDA receptor subunits. Nature 415:793-797.
13. Madry C, et al. (2007a) Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function. Biochem Biophys Res Commun 354:102-108.
14. Awobuluyi M, et al. (2007) Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-d-aspartate receptors. Mol Pharmacol 71:112-122.
15. Paoletti P, Ascher P, Neyton J (1997) High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 17:5711-5725.
16. Zheng F, et al. (2001) Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat Neurosci 4:894-901.
17. Rachline J, Perin-Dureau F, Le Goff A, Neyton J, Paoletti P (2005) The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J Neurosci 25:308-317.
18. Stys PK, Lipton SA (2007) White matter NMDA receptors: an unexpected new therapeutic target? Trends Pharmacol Sci 28:561-566.
19. Káradóttir R, Cavelier P, Bergersen LH, Attwell D (2005) NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 22:1162-1166.
20. Salter MG, Fern R (2005) NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature 438:1167-1171.
21. Micu I, et al. (2006) NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439:988-992.
22. Paoletti P, et al. (2000) Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit. Neuron 28:911-925.
23. 2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. Mol Pharmacol 72:1535-1544.
24. Kuryatov A, Laube B, Betz H, Kuhse J (1994) Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron 12:1291-1300.
25. Yao Y, Mayer ML (2006) Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. J Neurosci 26:4559-4566.
26. Stoll L, et al. (2007) Differential regulation of ionotropic glutamate receptors. Biophys J 92:1343-1349.
27. Changeux JP, Edelstein SJ (1998) Allosteric receptors after 30 years. Neuron 21:959-980.
28. Miller PS, Da Silva HM, Smart TG (2005) Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Biol Chem 280:37877-37884.
29. 2+-binding sites. Proc Natl Acad Sci USA 99:3210-3215.
30. Mayer ML (2006) Glutamate receptors at atomic resolution. Nature 440:456-462.
31. Frederickson CJ, et al. (2006) Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods 154:19-29.
32. 2+ as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52:679-690.
33. Furukawa H, Singh SK, Mancusso R, Gouaux E (2005) Subunit arrangement and function in NMDA receptors. Nature 438:185-192.
34. Mueller HT, Meador-Woodruff JH (2004) NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr Res 71:361-370.
35. Henson MA, et al. (2008) Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex. Cereb Cortex. doi:10.1093.
36. Laube B, et al. (1995) Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. J Physiol 483:613-619.