-
2
-
-
49249124305
-
Advances in the development of siRNA-based therapeutics for cancer
-
Shen Y. Advances in the development of siRNA-based therapeutics for cancer. I Drugs 2008;11:572-8.
-
(2008)
I Drugs
, vol.11
, pp. 572-578
-
-
Shen, Y.1
-
3
-
-
67649120076
-
Overcoming obstacles to develop effective and safe siRNA therapeutics
-
Li L, Shen Y. Overcoming obstacles to develop effective and safe siRNA therapeutics. Expert Opin Biol Ther 2009;9:609-19.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 609-619
-
-
Li, L.1
Shen, Y.2
-
4
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc A,Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008;26:561-9.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 561-569
-
-
Akinc Azumbuehl, A.1
Goldberg, M.2
Leshchiner, E.S.3
Busini, V.4
Hossain, N.5
-
5
-
-
57149086661
-
Atu027, a liposomal small interfering RNAformulation targeting protein kinase N3, inhibits cancer progression
-
Aleku M, Schulz P, Keil O, Santel A, Schaeper U, Dieckhoff B, et al. Atu027, a liposomal small interfering RNAformulation targeting protein kinase N3, inhibits cancer progression. Cancer Res 2008;68:9788-98.
-
(2008)
Cancer Res
, vol.68
, pp. 9788-9798
-
-
Aleku, M.1
Schulz, P.2
Keil, O.3
Santel, A.4
Schaeper, U.5
Dieckhoff, B.6
-
6
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005;65:8984-92.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
7
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, et al. RNAi-mediated gene silencing in non-human primates. Nature 2006;441:111-4.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
-
8
-
-
34548735210
-
Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes
-
Rozema DB, Lewis DL, Wakefield DH, Wong SC, Klein JJ, Roesch PL, et al. Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci U S A 2007;104:12982-7.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12982-12987
-
-
Rozema, D.B.1
Lewis, D.L.2
Wakefield, D.H.3
Wong, S.C.4
Klein, J.J.5
Roesch, P.L.6
-
9
-
-
65649085603
-
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
-
Judge AD, Robbins M, Tavakoli I, Levi J, Hu L, Fronda A, et al. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest 2009;119:661-73.
-
(2009)
J Clin Invest
, vol.119
, pp. 661-673
-
-
Judge, A.D.1
Robbins, M.2
Tavakoli, I.3
Levi, J.4
Hu, L.5
Fronda, A.6
-
10
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol 2010;28:172-6.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
Sandhu, A.P.4
Mui, B.L.5
Cho, C.K.6
-
11
-
-
79953002512
-
A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors
-
Lin X, Li L, Wang R, Wilcox D, Zhao X, Song J, et al. A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors. Rna 2011;17:603-12.
-
(2011)
Rna
, vol.17
, pp. 603-612
-
-
Lin, X.1
Li, L.2
Wang, R.3
Wilcox, D.4
Zhao, X.5
Song, J.6
-
12
-
-
0032991616
-
Stabilized plasmid-lipid particles: Construction and characterization
-
Wheeler JJ, Palmer L, Ossanlou M, MacLachlan I, Graham RW, Zhang YP, et al. Stabilized plasmid-lipid particles: construction and characterization. Gene Ther 1999;6:271-81.
-
(1999)
Gene Ther
, vol.6
, pp. 271-281
-
-
Wheeler, J.J.1
Palmer, L.2
Ossanlou, M.3
Maclachlan, I.4
Graham, R.W.5
Zhang, Y.P.6
-
13
-
-
20044396377
-
Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
-
Morrissey DV, Blanchard K, Shaw L, Jensen K, Lockridge JA, Dickinson B, et al. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology (Baltimore, MD) 2005;41:1349-56.
-
(2005)
Hepatology (Baltimore, MD)
, vol.41
, pp. 1349-1356
-
-
Morrissey, D.V.1
Blanchard, K.2
Shaw, L.3
Jensen, K.4
Lockridge, J.A.5
Dickinson, B.6
-
14
-
-
24944577514
-
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
-
Heyes J, Palmer L, Bremner K, MacLachlan I. Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. J Control Release 2005;107:276-87.
-
(2005)
J Control Release
, vol.107
, pp. 276-287
-
-
Heyes, J.1
Palmer, L.2
Bremner, K.3
Maclachlan, I.4
-
15
-
-
30344454418
-
Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes
-
Judge A, McClintock K, Phelps JR, Maclachlan I. Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. Mol Ther 2006;13:328-37.
-
(2006)
Mol Ther
, vol.13
, pp. 328-337
-
-
Judge, A.1
McClintock, K.2
Phelps, J.R.3
Maclachlan, I.4
-
16
-
-
84887466460
-
Inventors; Abbott Laboratories, assignee
-
United States patent US 20100104629. Apr 29
-
Dande PA, Hansen TM, Hubbard RD, Sarthy AV, Shen Y, Tian L, et al., inventors; Abbott Laboratories, assignee. Cationic lipids and uses thereof. United States patent US 20100104629. 2010 Apr 29.
-
(2010)
Cationic Lipids and Uses Thereof
-
-
Dande, P.A.1
Hansen, T.M.2
Hubbard, R.D.3
Sarthy, A.V.4
Shen, Y.5
Tian, L.6
-
17
-
-
84863294823
-
Cationic lipids percentage and processing temperature are critical in designing siRNA lipid nanoparticles
-
Zhao X, Liu Y, Song J, Yong H, Li L, Shen Y, et al. Cationic lipids percentage and processing temperature are critical in designing siRNA lipid nanoparticles. J Drug Target 2012;20: 281-9.
-
(2012)
J Drug Target
, vol.20
, pp. 281-289
-
-
Zhao, X.1
Liu, Y.2
Song, J.3
Yong, H.4
Li, L.5
Shen, Y.6
-
18
-
-
84863721493
-
Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery
-
Li L, Wang R, Wilcox D, Zhao X, Song J, Lin X, et al. Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther 2012;19:775-80.
-
(2012)
Gene Ther
, vol.19
, pp. 775-780
-
-
Li, L.1
Wang, R.2
Wilcox, D.3
Zhao, X.4
Song, J.5
Lin, X.6
-
19
-
-
0035817303
-
Intermembrane transfer of polyethylene glycol-modified phosphatidylethanolamine as a means to reveal surface-associated binding ligands on liposomes
-
Li WM, Xue L, Mayer LD, Bally MB. Intermembrane transfer of polyethylene glycol-modified phosphatidylethanolamine as a means to reveal surface-associated binding ligands on liposomes. Biochim Biophys Acta 2001;1513:193-206.
-
(2001)
Biochim Biophys Acta
, vol.1513
, pp. 193-206
-
-
Li, W.M.1
Xue, L.2
Mayer, L.D.3
Bally, M.B.4
-
20
-
-
33645235714
-
Diffusible-PEG-lipid stabilized plasmid lipid particles
-
MacLachlan I, Cullis P. "Diffusible-PEG-lipid stabilized plasmid lipid particles." Adv Genet 2005;53:157-88.
-
(2005)
Adv Genet
, vol.53
, pp. 157-188
-
-
Maclachlan, I.1
Cullis, P.2
-
21
-
-
0027415097
-
Interbilayer transfer of phospholipidanchored macromolecules via monomer diffusion
-
Silvius JR, Zuckermann MJ. Interbilayer transfer of phospholipidanchored macromolecules via monomer diffusion. Biochemistry 1993;32
-
(1993)
Biochemistry
, vol.32
-
-
Silvius, J.R.1
Zuckermann, M.J.2
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