Desensitization and internalization of endothelin receptor a; Impact of g protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32138-32148

  Gärtner, Florian ^a   Seidel, Thorsten ^b   Schulz, Uwe ^a   Gummert, Jan ^a   Milting, Hendrik ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN RECEPTORS; ENDOTHELIN STIMULATION; G PROTEIN COUPLED RECEPTORS; G PROTEIN-COUPLED RECEPTOR KINASE 2; OVER-EXPRESSION; PHOSPHORYLATION SITES; RECEPTOR REGULATION; REGULATORY MECHANISM;

ENZYMES; SIGNALING;

PHOSPHORYLATION;

ENDOTHELIN; ENDOTHELIN A RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PHOSPHOLIPASE C;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ENDOTHELIN; G PROTEIN-COUPLED RECEPTOR (GPCR); PHOSPHORYLATION; RECEPTOR DESENSITIZATION; RECEPTOR ENDOCYTOSIS; RECEPTOR REGULATION;

AMINO ACID SUBSTITUTION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, ENDOTHELIN; TYPE C PHOSPHOLIPASES;

EID: 84887444986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.461566     Document Type: Article

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