N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14579-14585

  Auton, Matthew ^a   Sowa, Katie E ^a   Behymer, Molly ^a   Cruz, Miguel A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING PLATELETS; AMINO ACID SEQUENCE; BINDING CAPACITIES; COATED SURFACE; CONFORMATIONAL CHANGE; DOMAIN COMPLEXES; FLANKING REGIONS; GLYCOPROTEIN (GP); HIGH SHEAR; HIGH SHEAR RATE; N-TERMINALS; PLATELET ACTIVATION; PLATELET ADHESION; STRUCTURAL CONFORMATIONS; STRUCTURAL STABILIZATION; SURFACE AREA; THROMBUS FORMATION; VON WILLEBRAND FACTOR; WHOLE BLOOD;

AMINO ACIDS; ANTIGEN-ANTIBODY REACTIONS; CHEMICAL ACTIVATION; CIRCULAR DICHROISM SPECTROSCOPY; DIFFERENTIAL SCANNING CALORIMETRY; GLYCOPROTEINS; PROTEINS; SHEAR STRESS;

PLATELETS;

A1A2A3 PROTEIN; FIBRINOGEN; GLYCOPROTEIN IB ALPHA; REGULATOR PROTEIN; RISTOCETIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DNA FLANKING REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGLUTINATION;

ANTI-BACTERIAL AGENTS; FEMALE; FIBRINOGEN; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MULTIPROTEIN COMPLEXES; PLATELET ACTIVATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RISTOCETIN; STRESS, PHYSIOLOGICAL; VON WILLEBRAND FACTOR;

EID: 84860376548     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348573     Document Type: Article

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