Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome

Cell Death and Disease

Volumn 4, Issue 10, 2013, Pages

  John, K ^a   Wielgosz, S ^a   Schulze Osthoff, K ^b,c   Bantel, H ^a   Hass, R ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Apoptosis; Biomarker; Caspases; Cytokeratin 18; HELLP syndrome; Pregnancy disorder

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE; CYTOKERATIN 18; LACTATE DEHYDROGENASE;

ADULT; APOPTOSIS; ARTICLE; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE MARKER; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; HELLP SYNDROME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL; PLACENTA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; TROPHOBLAST;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CASPASE 3; CELL DEATH; DELIVERY, OBSTETRIC; ENZYME ACTIVATION; FEMALE; HELLP SYNDROME; HUMANS; KERATIN-18; L-LACTATE DEHYDROGENASE; PLACENTA; PREGNANCY; REGRESSION ANALYSIS;

EID: 84887419115     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.408     Document Type: Article

References (44)

1. Metcalf D. Hematopoietic cytokines. Blood 2008; 111: 485-491
2. Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL et al. M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature 2013; 497: 239-243
3. Wei S, Dai XM, Stanley ER. Transgenic expression of CSF-1 in CSF-1 receptor-expressing cells leads to macrophage activation, osteoporosis, and early death. J Leukoc Biol 2006; 80: 1445-1453
4. Yu W, Chen J, Xiong Y, Pixley FJ, Dai XM, Yeung YG et al. CSF-1 receptor structure/ function in MacCsf1r-/- macrophages: Regulation of proliferation, differentiation, and morphology. J Leukoc Biol 2008; 84: 852-863
5. Sherr CJ. Mitogenic response to colony-stimulating factor 1. Trends Genet 1991; 7: 398-402
6. Chavez S, Aguilera A. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 1997; 11: 3459-3470
7. Chavez S, Garcia-Rubio M, Prado F, Aguilera A. Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 2001; 21: 7054-7064
8. Jimeno S, Rondon AG, Luna R, Aguilera A. The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 2002; 21: 3526-3535
9. Piruat JI, Aguilera A. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J 1998; 17: 4859-4872
10. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 2002; 417: 304-308
11. Reed R, Cheng H. TREX SR proteins and export of mRNA. Curr Opin Cell Biol 2005; 17: 269-273
12. Pena A, Gewartowski K, Mroczek S, Cuellar J, Szykowska A, Prokop A et al. Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. EMBO J 2012; 31: 1605-1616
13. Rehwinkel J, Herold A, Gari K, Kocher T, Rode M, Ciccarelli FL et al. Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol 2004; 11: 558-566
14. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev 2005; 19: 1512-1517
15. Tamura T, Mancini A, Joos H, Koch A, Hakim C, Dumanski J et al. FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Oncogene 1999; 18: 6488-6495
16. Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW. Cancer cells and normal cells differ in their requirements for Thoc1. Cancer Res 2007; 67: 6657-6664
17. Katahira J, Inoue H, Hurt E, Yoneda Y. Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. EMBO J 2009; 28: 556-567
18. Merz C, Urlaub H, Will CL, Luhrmann R. Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA 2007; 13: 116-128
19. Pierce A, Carney L, Hamza HG, Griffiths JR, Zhang L, Whetton BA et al. THOC5 spliceosome protein: A target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. Br J Haematol 2008; 141: 641-650
20. Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL et al. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia 2012
21. Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Farber S, Koch A et al. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol 2010; 8: 1
22. Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009; 458: 904-908
23. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5: 953-964
24. Dias AP, Dufu K, Lei H, Reed R. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat Commun 2010; 1: 97
25. Mancini A, Koch A, Whetton AD, Tamura T. The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene 2004; 23: 6581-6589
26. Wang J, Muntean AG, Hess JL. ECSASB2 mediates MLL degradation during hematopoietic differentiation. Blood 2012; 119: 1151-1161
27. Bach C, Buhl S, Mueller D, Garcia-Cuellar MP, Maethner E, Slany RK. Leukemogenic transformation by HOXA cluster genes. Blood 2010; 115: 2910-2918
28. Hess JL, Bittner CB, Zeisig DT, Bach C, Fuchs U, Borkhardt A et al. c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood 2006; 108: 297-304
29. Skokowa J, Welte K. Dysregulation of myeloid-specific transcription factors in congenital neutropenia. Ann NY Acad Sci 2009; 1176: 94-100
30. Glesne D, Huberman E. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. Oncogene 2006; 25: 4086-4098
31. Wheadon H, Ramsey JM, Dobbin E, Dickson GJ, Corrigan PM, Freeburn RW et al. Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells Dev 2011; 20: 1465-1476
32. Guria A, Tran DD, Ramachandran S, Koch A, El Bounkari O, Dutta P et al. Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts. RNA 2011; 17: 1048-1056
33. Kopytova DV, Orlova AV, Krasnov AN, Gurskiy DY, Nikolenko JV, Nabirochkina EN et al. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Genes Dev 2010; 24: 86-96
34. Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa Y. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. Nucleic Acids Res 2013; 41: 7060-7072
35. Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T. An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. Rna 2011; 17: 1957-1966
36. Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G et al. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell 2012; 150: 279-290
37. Rollenhagen C, Hodge CA, Cole CN. Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export. Eukaryot Cell 2007; 6: 505-513
38. Elkon R, Ugalde AP, Agami R. Alternative cleavage and polyadenylation: Extent, regulation and function. Nat Rev Genet 2013; 14: 496-506
39. Vooijs M, Jonkers J, Berns A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2001; 2: 292-297
40. Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N et al. IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IkappaBzeta mRNA. J Biol Chem 2010; 285: 29165-29178
41. Koch A, Scherr M, Breyer B, Mancini A, Kardinal C, Battmer K et al. Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover. Oncogene 2008; 27: 4678-4689
42. Mancini A, El Bounkari O, Norrenbrock AF, Scherr M, Schaefer D, Eder M et al. FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha. Oncogene 2007; 26: 1020-1027
43. Zhao F, Xuan Z, Liu L, Zhang MQ. TRED: A Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies. Nucleic Acids Res 2005; 33: D103-D107
44. Perier RC, Praz V, Junier T, Bonnard C, Bucher P. The eukaryotic promoter database (EPD). Nucleic Acids Res 2000; 28: 302-303