Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 46, 2013, Pages 18626-18631

  Hosokawa, Hiroyuki ^a   Tanaka, Tomoaki ^a   Kato, Miki ^a   Shinoda, Kenta ^a   Tohyama, Hiroyuki ^a   Hanazawa, Asami ^a   Tamaki, Yuuki ^a   Hirahara, Kiyoshi ^a   Yagi, Ryoji ^a   Sakikawa, Ikue ^b   Morita, Atsushi ^b   Nagira, Morio ^c   Poyurovsky, Masha V ^c   Suzuki, Yutaka ^d   Motohashi, Shinichiro ^e   Nakayama, Toshinori ^a  

^a CHIBA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

^d Kadmon Research Institute   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Master transcription factor; Polycomb group complex; Transcriptional regulation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2C; PROTEIN; RUVB LIKE PROTEIN 2; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; GENE LOCUS; GENE SILENCING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH2 CELL; TRANSACTIVATION; TRANSCRIPTION REGULATION;

MASTER TRANSCRIPTION FACTOR; POLYCOMB GROUP COMPLEX; TRANSCRIPTIONAL REGULATION;

ANIMALS; BROMODEOXYURIDINE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P18; DNA HELICASES; DNA PRIMERS; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUCIFERASES; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; REAL-TIME POLYMERASE CHAIN REACTION; TH2 CELLS;

EID: 84887413097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311100110     Document Type: Article

References (38)

1. Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28:445-489.
2. Reiner SL (2007) Development in motion: Helper T cells at work. Cell 129(1):33-36.
3. Kurata H, Lee HJ, O'Garra A, Arai N (1999) Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11(6):677-688. (Pubitemid 30030707)
4. Onodera A, et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207(11):2493-2506.
5. Yamashita M, et al. (2005) Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J Biol Chem 280(33):29409-29419. (Pubitemid 41177013)
6. Shinnakasu R, et al. (2008) Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J Biol Chem 283(42):28216-28225.
7. Hosoya T, Maillard I, Engel JD (2010) From the cradle to the grave: Activities of GATA-3 throughout T-cell development and differentiation. Immunol Rev 238(1):110-125.
8. Rothenberg EV, Scripture-Adams DD (2008) Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Semin Immunol 20(4):236-246.
9. Ansel KM, Djuretic I, Tanasa B, Rao A (2006) Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24:607-656.
10. Horiuchi S, et al. (2011) Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J Immunol 186(11):6378-6389.
11. Wei G, et al. (2011) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35(2):299-311.
12. Nakayama T, Yamashita M (2008) Initiation and maintenance of Th2 cell identity. Curr Opin Immunol 20(3):265-271.
13. Grogan JL, et al. (2001) Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14(3):205-215. (Pubitemid 32289286)
14. Zhu J, et al. (2002) Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16(5):733-744. (Pubitemid 34626693)
15. Zhu J, et al. (2004) Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 5(11):1157-1165. (Pubitemid 39549630)
16. Nagasawa M, Melamed I, Kupfer A, Gelfand EW, Lucas JJ (1997) Rapid nuclear translocation and increased activity of cyclin-dependent kinase 6 after T cell activation. J Immunol 158(11):5146-5154. (Pubitemid 127681216)
17. Ortega S, Malumbres M, Barbacid M (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602(1):73-87. (Pubitemid 34311901)
18. Kovalev GI, Franklin DS, Coffield VM, Xiong Y, Su L (2001) An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. J Immunol 167(6):3285-3292. (Pubitemid 32852569)
19. Pei XH, et al. (2009) CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell 15(5):389-401.
20. Tanaka T, Ohkubo S, Tatsuno I, Prives C (2007) hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130(4):638-650. (Pubitemid 47268061)
21. Molenaar JJ, et al. (2010) Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells. Oncogene 29(18):2739-2745.
22. Bates DL, Chen Y, Kim G, Guo L, Chen L (2008) Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol 381(5):1292-1306.
23. Lowry JA, Atchley WR (2000) Molecular evolution of the GATA family of transcription factors: conservation within the DNA-binding domain. J Mol Evol 50(2):103-115. (Pubitemid 30429986)
24. Yang Z, et al. (1994) Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains. Mol Cell Biol 14(3):2201-2212. (Pubitemid 24074617)
25. Hosokawa H, et al. (2006) Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol 177(11):7656-7664. (Pubitemid 44846280)
26. Qi D, Jin H, Lilja T, Mannervik M (2006) Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics 174(1):241-251. (Pubitemid 44427669)
27. Diop SB, et al. (2008) Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. EMBO Rep 9(3):260-266. (Pubitemid 351330991)
28. Miki-Hosokawa T, et al. (2009) CD69 controls the pathogenesis of allergic airway inflammation. J Immunol 183(12):8203-8215.
29. Ku CJ, Hosoya T, Maillard I, Engel JD (2012) GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood 119(10):2242-2251.
30. Huen J, et al. (2010) Rvb1-Rvb2: Essential ATP-dependent helicases for critical complexes. Biochem Cell Biol 88(1):29-40.
31. Jha S, Dutta A (2009) RVB1/RVB2: Running rings around molecular biology. Mol Cell 34(5):521-533.
32. Jónsson ZO, et al. (2001) Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem 276(19):16279-16288.
33. Arnold CN, et al. (2012) A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci USA 109(31):12286-12293.
34. Yu M, et al. (2009) Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 36(4):682-695.
35. Fujiwara T, et al. (2009) Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 36(4):667-681.
36. He A, Kong SW, Ma Q, Pu WT (2011) Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci USA 108(14):5632-5637.
37. Hosokawa H, et al. (2013) Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc Natl Acad Sci USA 110(12):4691-4696.
38. Yamashita M, et al. (2006) Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24(5):611-622. (Pubitemid 43728153)