Sperm PLCζ: From structure to Ca2+ oscillations, egg activation and therapeutic potential

FEBS Letters

Volumn 587, Issue 22, 2013, Pages 3609-3616

  Nomikos, Michail ^a   Kashir, Junaid ^a   Swann, Karl ^a   Lai, F Anthony ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Calcium signaling; Egg activation; Fertilization; Infertility; Phospholipase C (PLC); Phospholipase C zeta (PLC ); Sperm

Indexed keywords

CALCIUM ION; MESSENGER RNA; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C ZETA; PROTEIN KINASE C; RECOMBINANT PHOSPHOLIPASE C ZETA; UNCLASSIFIED DRUG;

CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL VACUOLE; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME RELEASE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; FERTILIZATION IN VITRO; HUMAN; HYDROLYSIS; INTRACYTOPLASMIC SPERM INJECTION; MALE FERTILITY; MALE INFERTILITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SPERM; SPERMATOZOON COUNT; SUBFERTILITY; TESTIS;

CALCIUM SIGNALING; EGG ACTIVATION; FERTILIZATION; INFERTILITY; PHOSPHOLIPASE C (PLC); PHOSPHOLIPASE C ZETA (PLCΖ); SPERM;

ANIMALS; CALCIUM SIGNALING; FERTILIZATION; HUMANS; INFERTILITY; MALE; OOCYTES; PHOSPHOINOSITIDE PHOSPHOLIPASE C; PROTEIN TRANSPORT; SPERMATOZOA;

MAMMALIA;

EID: 84887406850     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.10.008     Document Type: Review

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