Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ

Biochemical Journal

Volumn 434, Issue 2, 2011, Pages 211-217

  Nomikos, Michail ^a,b   Elgmati, Khalil ^a   Theodoridou, Maria ^b   Calver, Brian L ^a   Cumbes, Bevan ^a   Nounesis, Georg ^b   Swann, Karl ^a   Lai, F Anthony ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Calcium oscillation; Egg activation; Fertilization; Infertility; Phospholipase C (PLC); Phospholipase C (PLC )

Indexed keywords

LUCIFERASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE; PHOSPHOLIPASE C ZETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; FEMALE; HYDROLYSIS; IN VITRO STUDY; MALE; MALE INFERTILITY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOZOON MOTILITY;

ANIMALS; CALCIUM; CALCIUM SIGNALING; FEMALE; HUMANS; HYDROLYSIS; INFERTILITY, MALE; MALE; MICE; OOCYTES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOINOSITIDE PHOSPHOLIPASE C; POINT MUTATION; SPERMATOZOA;

EID: 79951548080     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101772     Document Type: Article

References (19)

1. Stricker, S. A. (1999) Comparative biology of calcium signaling during fertilization and egg activation in animals. Dev. Biol. 211, 157-176
2. Runft, L. L., Jaffe, L. A. and Mehlmann, L. M. (2002) Egg activation at fertilization: where it all begins. Dev. Biol. 245, 237-254
3. Swann, K. (1990) A cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster eggs. Development 110, 1295-1302
4. Schultz, R. M. and Kopf, G. S. (1995) Molecular basis of mammalian egg activation. Curr. Top. Dev. Biol. 30, 21-62
5. 2+ oscillations in the activation of the egg and development of the embryo in mammals. Int. J. Dev. Biol. 42, 1-10
6. 2+ oscillations in eggs and embryo development. Development 129, 3533-3544
7. 2+ oscillations, activation and development of mouse oocytes. Reproduction 124, 611-623
8. 2+ oscillations in mouse eggs. J. Biol. Chem. 279, 10408-10412
9. 2+ oscillations during fertilization. Biol. Reprod. 72, 992-996
10. 2+ oscillations and egg activation in mammals. Semin. Cell Dev. Biol. 17, 264-273
11. Suh, P. G., Park, J. I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S. and Ryu, S. H. (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41, 415-434
12. 2+ release and are unable to initiate the first step of embryo development. J. Clin. Invest. 118, 3671-3681
13. Heytens, E., Parrington, J., Coward, K., Young, C., Lambrecht, S., Yoon, S. Y., Fissore, R. A., Hamer, R., Deane, C. M., Ruas, M. et al. (2009) Reduced amounts and abnormal forms of phospholipase C ζ (PLCζ) in spermatozoa from infertile men. Hum. Reprod. 24, 2417-2428
14. Saunders, C. M., Swann, K. and Lai, F. A. (2007) PLCζ, a sperm-specific PLC and its potential role in fertilization. Biochem. Soc. Symp. 74, 23-36
15. 2+ oscillations. J. Biol. Chem. 280, 31011-31018
16. Summers, M. C., McGinnis, L. K., Lawitts, J. A., Raffin, M. and Biggers, J. D. (2000) IVF of mouse ova in a simplex optimized medium supplemented with amino acids. Hum. Reprod. 15, 1791-1801
17. Ellis, M. V., James, S. R., Perisic, O., Downes, C. P., Williams, R. L. and Katan, M. (1998) Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcδ1. J. Biol. Chem. 273, 11650-11659
18. Heindryckx, B., De Gheselle, S., Gerris, J., Dhont, M. and De Sutter, P. (2008) Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection. Reprod. Biomed. Online 17, 662-668
19. Nasr-Esfahani, M. H., Deemeh, M. R. and Tavalaee, M. (2010) Artificial oocyte activation and intracytoplasmic sperm injection. Fertil. Steril. 94, 520-526