Mechanism of in vivo anticoagulant and haemolytic activity by a neutral phospholipase A2 purified from Daboia russelii russelii venom: Correlation with clinical manifestations in Russell's Viper envenomed patients

Toxicon

Volumn 76, Issue , 2013, Pages 291-300

  Saikia, Debashree ^a   Majumdar, Sourav ^a   Mukherjee, Ashis K ^a,b  

^a TEZPUR UNIVERSITY   (India)

^b UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

Anticoagulant activity; Haemolysis; Phospholipids hydrolysis; Russell's Viper venom

Indexed keywords

NEUPHOLIPASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DABOIA RUSSELLII; ENVENOMATION; ENZYME ACTIVITY; ENZYME BINDING; ERYTHROCYTE COUNT; ERYTHROCYTE MEMBRANE; GAS CHROMATOGRAPHY; HEMOLYSIS; IN VIVO STUDY; LEUKOCYTE COUNT; LIPID HYDROLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

DABOIA RUSSELLII; MUS; VIPERINAE;

ANTICOAGULANT ACTIVITY; HAEMOLYSIS; NEUTRAL PLA(2); PHOSPHOLIPIDS HYDROLYSIS; RUSSELL'S VIPER VENOM;

ANIMALS; ANTICOAGULANTS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GOATS; HEMOLYTIC AGENTS; HUMANS; MICE; MICE, INBRED BALB C; PEPTIDE MAPPING; PHOSPHOLIPASES A2; RUSSELL'S VIPER; SNAKE BITES; SUBSTRATE SPECIFICITY; VIPER VENOMS;

EID: 84887351007     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.10.001     Document Type: Article

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