An acidic phospholipase A2 (RVVA-PLA2-I) purified from Daboia russelli venom exerts its anticoagulant activity by enzymatic hydrolysis of plasma phospholipids and by non-enzymatic inhibition of factor Xa in a phospholipids/Ca2+ independent manner

Toxicon

Volumn 57, Issue 6, 2011, Pages 841-850

  Saikia, Debashree ^a   Thakur, Rupamoni ^a   Mukherjee, Ashis K ^a  

^a TEZPUR UNIVERSITY   (India)

Author keywords

Acidic phospholipase A2; Anticoagulant activity; Factor Xa inhibition; Inhibition of prothrombin activation; Phospholipids hydrolysis; Russell's viper venom

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CALCIUM ION; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PROTHROMBIN; SNAKE VENOM; THROMBIN;

ANTICOAGULATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DABOIA RUSSELLI; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; GEL FILTRATION; HYDROLYSIS; IN VITRO STUDY; MOLECULAR WEIGHT; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SNAKE; SPECTROFLUOROMETRY;

ANIMALS; ANTICOAGULANTS; CALCIUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR XA; FLUORESCENCE; HYDROLYSIS; INDIA; PHOSPHOLIPASES; PHOSPHOLIPIDS; PROTHROMBIN; RUSSELL'S VIPER; VIPER VENOMS;

AZADIRACHTA INDICA; DABOIA RUSSELLII; VIPERINAE;

EID: 79955026917     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.02.018     Document Type: Article

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