Potential markers of cisplatin treatment response unveiled by NMR metabolomics of human lung cells

Molecular Pharmaceutics

Volumn 10, Issue 11, 2013, Pages 4242-4251

  Duarte, I F ^a   Ladeirinha, A F ^b   Lamego, I ^a   Gil, A M ^a   Carvalho, L ^b,c   Carreira, I M ^b   Melo, J B ^b  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

A549 lung cells; cisplatin; HRMAS NMR; metabolic profile; metabolomics

Indexed keywords

ALANINE; CHOLESTEROL; CISPLATIN; CITRULLINE; GLUTAMINE; LYSINE; METHIONINE; NICOTINAMIDE; PHENYLALANINE; SORBITOL; TYROSINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EXPOSURE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; METABOLITE; METABOLOME; METABOLOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT RESPONSE;

AMINO ACIDS; CELL LINE, TUMOR; CISPLATIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; NIACINAMIDE; SORBITOL;

EID: 84887331225     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400335k     Document Type: Article

References (49)

1. Coen, M.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. NMR-Based Metabolic Profiling and Metabonomic Approaches to Problems in Molecular Toxicology Chem. Res. Toxicol. 2008, 21, 9-27
2. Robertson, D. G.; Watkins, P. B.; Reily, M. D. Metabolomics in Toxicology: Preclinical and Clinical Applications Toxicol. Sci. 2011, 120, S146-S170
3. Khoo, S. H. G.; Al-Rubeai, M. Metabolomics as a Complementary Tool in Cell Culture Biotechnol. Appl. Biochem. 2007, 47, 71-84
4. Cuperlovic-Culf, M.; Barnett, A. D.; Culf, A. S.; Chute, I. Cell Culture Metabolomics: Applications and Future Directions Drug Discovery Today 2010, 15, 610-621
5. Lutz, N. W. From Metabolic to Metabolomic NMR Spectroscopy of Apoptotic Cells Metabolomics 2005, 1, 251-268
6. Duarte, I. F.; Lamego, I.; Rocha, C.; Gil, A. M. NMR Metabonomics for Mammalian Cell Metabolism Studies Bioanalysis 2009, 1, 1597-1614
7. García-álvarez, I.; Fernández-Mayoralas, A.; Garrido, L. Effect of Drugs in Cells and Tissues by NMR Spectroscopy Curr. Top. Med. Chem. 2011, 11, 27-42
8. Huang, Z.; Tong, Y.; Wang, J.; Huang, Y. NMR Studies of the Relationship Between the Changes of Membrane Lipids and the Cisplatin-Resistance of A549/DDP Cells Cancer Cell Int. 2003, 3, 5
9. Duarte, I. F.; Lamego, I.; Marques, J.; Marques, M. P. M.; Blaise, B. J.; Gil, A. M. Nuclear Magnetic Resonance (NMR) Study of the Effect of Cisplatin on the Metabolic Profile of MG-63 Osteosarcoma Cells J. Proteome Res. 2010, 9, 5877-5886
10. 1H Magnetic Resonance Spectroscopy Metabolites as Biomarkers for Cell Cycle Arrest and Cell Death in Rat Glioma Cells. Int J. Biochem. Cell Biol. 2011, 43, 990-1001
11. Mirbahai, L.; Wilson, M.; Shaw, C. S.; McConville, C.; Malcomson, R. D. G.; Kauppinen, R. A.; Peet, A. C. Lipid Biomarkers of Glioma Cell Growth Arrest and Cell Death Detected by 1H Magic Angle Spinning MRS NMR Biomed. 2012, 25, 1253-1262
12. Pan, X.; Wilson, M.; Mirbahai, L.; McConville, C.; Arvanitis, T. N.; Griffin, J. L.; Kauppinen, R. A.; Peet, A. C. In Vitro Metabonomic Study Detects Increases in UDP-GlcNAc and UDP-GalNAc, as Early Markers of Cisplatin Treatment Response in Brain Tumor Cells J. Proteome Res. 2011, 10, 3493-3500
13. 1H-NMR of Apoptosis and Necrosis in HL60 Leukemia Cells: Differences between the Two Types of Cell Death and Independence from the Stimulus of Apoptosis Used Radiat. Res. 2008, 169, 170-180
14. Triba, M. N.; Starzec, A.; Bouchemal, N.; Guenin, E.; Perret, G. Y.; Moyec, L. L. Metabolomic Profiling with NMR Discriminates Between Biphosphonate and Doxurubicin Effects on B16 Melanoma cells NMR Biomed. 2010, 23, 1009-1016
15. Bayet-Robert, M.; Morvan, D.; Chollet, P.; Barthomeuf, C. Pharmacometabolomics of Docetaxel-Treated Human MCF-7 Breast Cancer Cells Provides Evidence of Varying Cellular Responses at High and Low Doses Breast Cancer Res. Treat. 2010, 120, 613-626
16. 1H-NMR Spectroscopy-Based Metabolite Profiling of Human Cancer Cell Lines and Response to Chemotherapy Magn. Reson. Med. 2010, 63, 1172-1183
17. Klawitter, J.; Anderson, N.; Klawitter, J.; Christians, U.; Leibfritz, D.; Eckhardt, S. G.; Serkova, N. J. Time-Dependent Effects of Imatinib in Human Leukaemia Cells: a Kinetic NMR-Profiling Study Br. J. Cancer 2009, 100, 923-931
18. Lodi, A.; Ronen, S. M. Magnetic Resonance Spectroscopy Detectable Metabolomic Fingerprint of Response to Antineoplastic Treatment PLoS One 2011, 6, e26155
19. Foster, K. A.; Oster, C. G.; Mayer, M. M.; Avery, M. L.; Audus, K. L. Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism Exp. Cell Res. 1998, 243, 359-366
20. Zhukova, O. S.; Gerasimova, G. K.; Shubina, I. Z.; Kiselevskii, M. V. Combined Effect of Cisplatin and Lymphokine-Activated Killer Cells on A549 Cells of Non-Small Cell Lung Cancer Bull. Exp. Biol. Med. 2007, 144, 231-234
21. Mosmann, T. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays J. Immunol. Methods 1983, 65, 55-63
22. Melo, J. B.; Sousa, C.; Garção, P.; Oliveira, C. R.; Agostinho, P. Galantamine Protects Against Oxidative Stress Induced by Amyloid Beta-Peptide in Cortical Neurons Eur. J. Neurosci. 2009, 29, 455-464
23. Wishart, D. S.; Knox, C.; Guo, A. C.; Eisner, R.; Young, N.; Gautam, B.; Hau, D. D.; Psychogios, N.; Dong, E.; Bouatra, S.; Mandal, R.; Sinelnikov, I.; Xia, J.; Jia, L.; Cruz, J. A.; Lim, E.; Sobsey, C. A.; Shrivastava, S.; Huang, P.; Liu, P.; Fang, L.; Peng, J.; Fradette, R.; Cheng, D.; Tzur, D.; Clements, M.; Lewis, A.; De Souza, A.; Zuniga, A.; Dawe, M.; Xiong, Y.; Clive, D.; Greiner, R.; Nazyrova, A.; Shaykhutdinov, R.; Li, L.; Vogel, H. J.; Forsythe, I. HMDB: a Knowledgebase for the Human Metabolome Nucleic Acids Res. Suppl. 2009, 37 (1) D603-D610
24. Cloarec, O.; Dumas, M. E.; Craig, A.; Barton, R. H.; Trygg, J.; Hudson, J.; Blancher, C.; Gauguier, D.; Lindon, J. C.; Holmes, E.; Nicholson, J. Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolomic H-1 NMR Data Sets Anal. Chem. 2005, 77, 1282-1289
25. Veselkov, K. A.; Lindon, J. C.; Ebbels, T. M. D.; Crockford, D.; Volynkin, V. V.; Holmes, E.; Davies, D. B.; Nicholson, J. K. Recursive Segment-Wise Peak Alignment of Biological H-1 NMR Spectra for Improved Metabolic Biomarker Recovery Anal. Chem. 2009, 81, 56-66
26. 1H NMR Metabonomics Anal. Chem. 2006, 78, 4281-4290
27. Grande, S.; Palma, A.; Luciani, A. M.; Rosi, A.; Guidoni, L.; Viti, V. Glycosidic Intermediates Identified in H-1 MR Spectra of Intact Tumour Cells May Contribute to the Clarification of Aspects of Glycosylation Pathways NMR Biomed. 2011, 24, 68-79
28. Remy, C.; Fouilhe, N.; Barba, I.; Sam-Lai, E.; Lahrech, H.; Cucurella, M.-G.; Izquierdo, M.; Moreno, A.; Ziegler, A.; Massarelli, R.; Decorps, M.; Arus, C. Evidence that Mobile Lipids Detected in Rat Brain Glioma by H-1 Nuclear Magnetic Resonance Correspond to Lipid Droplets Cancer Res. 1997, 57, 407-414
29. 1H NMR Visible Lipids in the Life and Death of Cells Trends Biochem. Sci. 2000, 25, 357-362
30. Delikatny, E. J.; Chawla, S.; Leung, D.-J.; Poptani, H. MR-Visible Lipids and the Tumor Microenvironment NMR Biomed. 2011, 24, 592-611
31. Quintero, M.; Cabanas, M. E.; Arus, C. A Possible Cellular Explanation for the NMR-Visible Mobile Lipid (ML) Changes in Cultured C6 Glioma Cells with Growth Biochim. Biophys. Acta 2007, 1771, 31-44
32. Pan, X.; Wilson, M.; McConville, C.; Brundler, M.-A; Arvanitis, T. N.; Shockcor, J. P.; Griffin, J. L.; Kauppinen, R. A.; Peet, A. C. The Lipid Composition of Isolated Cytoplasmic Lipid Droplets from a Human Cancer Cell Line, BE(2)M17 Mol. BioSyst. 2012, 8, 1694-1700
33. Farese, R. V.; Walther, T. C. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T Cell 2009, 139, 855-860
34. 1H NMR Visible Mobile Lipids During Apoptosis of Paclitaxel-Treated K562 Cells Biochem. Pharmacol. 2003, 65, 1271-1280
35. Milkevitch, M.; Shim, H.; Pilatus, U.; Pickup, S.; Wehrle, J. P.; Samid, D.; Poptani, H.; Glickson, J. D.; Delikatny, E. J. Increases in NMR-Visible Lipid and Glycerophosphocholine During Phenylbutyrate-Induced Apoptosis in Human Prostate Cancer Cells Biochim. Biophys. Acta 2005, 1734, 1-12
36. Boren, J.; Brindle, K. M. Apoptosis-Induced Mitochondrial Dysfunction Causes Cytoplasmic Lipid Droplet Formation Cell Death Differ. 2012, 19, 1561-1570
37. Montopoli, M.; Bellanda, M.; Lonardoni, F.; Ragazzi, E.; Dorigo, P.; Froldi, G.; Mammi, S.; Caparrotta, L. Metabolic Reprogramming" in Ovarian Cancer Cells Resistant to Cisplatin Curr. Cancer Drug Targets 2011, 11, 226-235
38. Zietkowski, D.; Payne, G. S.; Nagy, E.; Mobberley, M. A.; Ryder, T. A.; De Souza, N. M. Comparison of NMR Lipid Profiles in Mitotic Arrest and Apoptosis as Indicators of Paclitaxel Resistance in Cervical Cell Lines Magn. Reson. Med. 2012, 68, 369-377
39. Al-Saffar, N. M. S.; Titley, J. C.; Robertson, D.; Clarke, P. A.; Leach, L. E.; Ronen, S. M. Apoptosis Is Associated with Triacylglycerol Accumulation in Jurkat T-Cells Br. J. Cancer 2002, 86, 963-970
40. Iorio, E.; Vito, M. D.; Spadaro, F.; Ramoni, C.; Lococo, E.; Carnevale, R.; Lenti, L.; Strom, R.; Podo, F. Triacsin C Inhibits the Formation of 1H NMR-Visible Mobile Lipids and Lipid Bodies in HuT 78 Apoptotic Cells Biochim. Biophys. Acta 2003, 1634, 1-14
41. Milkevitch, M.; Beardsley, N. J.; Delikatny, E. J. Phenylbutyrate Induces Apoptosis and Lipid Accumulations Via a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Pathway NMR Biomed. 2010, 23, 473-479
42. Milkevitch, M.; Jeitner, T. M.; Beardsley, N. J.; Delikatny, E. J. Lovastatin Enhances Phenylbutyrate-Induced MR-Visible Glycerophosphocholine but Not Apoptosis in DU145 Prostate Cells Biochim. Biophys. Acta 2007, 1771, 1166-1176
43. 1H Detects Polyunsaturated Fatty Acid Accumulation During Gene Therapy of Glioma: Implications for the In Vivo Detection of Apoptosis Nat. Med. 1999, 5, 1323-1327
44. Griffin, J. L.; Lehtimaki, K. K.; Valonen, P. K.; Grohn, O. H. J.; Kettunen, M. I.; Yla-Herttuala, S.; Pitkanen, A.; Nicholson, J. K.; Kauppinen, R. A. Assignment of 1H Nuclear Magnetic Resonance Visible Polyunsaturated Fatty Acids in BT4C Gliomas Undergoing Ganciclovir-Thymidine Kinase Gene Therapy-Induced Programmed Cell Death Cancer Res. 2003, 63, 3195-3201
45. Ohtsubo, K.; Marth, J. D. Glycosylation in Cellular Mechanisms of Health and Disease Cell 2006, 126, 855-867
46. 1H NMR study Br. J. Cancer 2002, 86, 1180-1187
47. Alim, Z.; Beydemir, S. Effects of Some Anti-Neoplastic Drugs on Sheep Liver Sorbitol Dehydrogenase Arch. Physiol. Biochem. 2012, 118, 244-252
48. Vulimiri, S. V.; Misra, M.; Hamm, J. T.; Mitchell, M.; Berger, A. Effects of Mainstream Cigarette Smoke on the Global Metabolome of Human Lung Epithelial Cells Chem. Res. Toxicol. 2009, 22, 492-503
49. Fan, T. W. M.; Bandura, L. L.; Higashi, R. M.; Lane, A. N. Metabolomics-Edited Transcriptomics Analysis of Se Anticancer Action in Human Lung Cancer Cells Metabolomics 2005, 1, 325-339