Development of Genetic System to Inactivate a Borrelia turicatae Surface Protein Selectively Produced within the Salivary Glands of the Arthropod Vector

PLoS Neglected Tropical Diseases

Volumn 7, Issue 10, 2013, Pages

  Lopez, Job E ^a   Wilder, Hannah K ^a   Hargrove, Reid ^a   Brooks, Christopher P ^a   Peterson, Karin E ^b   Beare, Paul A ^b   Sturdevant, Daniel E ^b   Nagarajan, Vijayaraj ^c   Raffel, Sandra J ^b   Schwan, Tom G ^b  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GENTAMICIN; MEMBRANE PROTEIN;

ARTHROPOD; ARTICLE; BACTERIAL GENETICS; BACTERIUM ISOLATION; BORRELIA; BORRELIA TURICATAE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DISEASE CARRIER; DISEASE TRANSMISSION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IMMUNOGENICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DENATURATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SALIVARY GLAND; SEQUENCE ANALYSIS; SOUTHERN BLOTTING;

ANIMALS; BACTERIAL PROTEINS; BORRELIA; DNA, BACTERIAL; GENE EXPRESSION PROFILING; GENE KNOCKOUT TECHNIQUES; HOST-PATHOGEN INTERACTIONS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PLASMIDS; REAL-TIME POLYMERASE CHAIN REACTION; SALIVARY GLANDS; SEQUENCE ANALYSIS, DNA; TICKS;

EID: 84887269317     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002514     Document Type: Article

References (41)

1. Felsenfeld O, (1973) The problem of relapsing fever in the Americas. IMS Ind Med Surg 42: 7-10.
2. Balashov YS, (1972) Bloodsucking ticks (Ixodoidea)- vectors of diseases of man and animals. Misc Publ Entomol Soc Am 8: 161-376.
3. Davis GE, (1941) Ornithodoros turicata:the males; feeding and copulation habits, fertility, span of life, and the transmission of relapsing fever spirochetes. Pub Health Rep 56: 1799-1802.
4. Francis E, (1938) Longevity of the tick Ornithodoros turicata and of Spirochaeta recurrentis with this tick. Publ Hlth Rep 53: 2220-2241.
5. Miller SC, Porcella SF, Raffel SJ, Schwan TG, Barbour AG, (2013) Large linear plasmids of borrelia species that cause relapsing Fever. J Bacteriol 195: 3629-3639.
6. Schwan TG, Raffel SJ, Schrumpf ME, Policastro PF, Rawlings JA, et al. (2005) Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida. J Clin Microbiol 43: 3851-3859.
7. Barbour AG, (1984) Isolation and cultivation of Lyme disease spirochetes. Yale J Biol Med 57: 521-525.
8. Battisti JM, Raffel SJ, Schwan TG, (2008) A system for site-specific genetic manipulation of the relapsing fever spirochete Borrelia hermsii. Methods Mol Biol 431: 69-84.
9. Lopez JE, Schrumpf ME, Nagarajan V, Raffel SJ, McCoy BN, et al. (2010) A novel surface antigen of relapsing fever spirochetes can discriminate between relapsing fever and Lyme borreliosis. Clin Vaccine Immunol 17: 564-571.
10. Hulo N, Bairoch A, Bulliard V, Cerutti L, Cuche BA, et al. (2008) The 20 years of PROSITE. Nucleic Acids Res 36: D245-249.
11. Juncker AS, Willenbrock H, Von Heijne G, Brunak S, Nielsen H, et al. (2003) Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci 12: 1652-1662.
12. de Castro E, Sigrist CJ, Gattiker A, Bulliard V, Langendijk-Genevaux PS, et al. (2006) ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins. Nucleic Acids Res 34: W362-365.
13. Rice P, Longden I, Bleasby A, (2000) EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 16: 276-277.
14. Porcella SF, Raffel SJ, Anderson Jr. DE, Gilk SD, Bono JL, et al. (2005) Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America. Infect Immun 73: 6647-6658.
15. Lopez JE, Schrumpf ME, Raffel SJ, Policastro PF, Porcella SF, et al. (2008) Relapsing fever spirochetes retain infectivity after prolonged in vitro cultivation. Vector Borne Zoonotic Dis 8: 813-820.
16. Winston PW, Bates DH, (1960) Saturated solutions for the control of humidity in biological research. Ecology 41: 232-237.
17. Guyard C, Chester EM, Raffel SJ, Schrumpf ME, Policastro PF, et al. (2005) Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences. Infect Immun 73: 3025-3037.
18. Schwan TG, Kime KK, Schrumpf ME, Coe JE, Simpson WJ, (1989) Antibody response in white-footed mice (Peromyscus leucopus) experimentally infected with the Lyme disease spirochete (Borrelia burgdorferi). Infect Immun 57: 3445-3451.
19. Schwan TG, Schrumpf ME, Hinnebusch BJ, Anderson DE, Konkel ME, (1996) GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. J Clin Microbiol 34: 2483-2492.
20. McCoy BN, Raffel SJ, Lopez JE, Schwan TG, (2010) Bloodmeal size and spirochete acquisition of Ornithodoros hermsi (Acari: Argasidae) during feeding. J Med Entomol 47: 1164-1172.
21. McGarey DJ, Barbet AF, Palmer GH, McGuire TC, Allred DR, (1994) Putative adhesins of Anaplasma marginale: major surface polypeptides 1a and 1b. Infect Immun 62: 4594-4601.
22. Schwan TG, Hinnebusch BJ, (1998) Bloodstream- versus tick-associated variants of a relapsing fever bacterium. Science 280: 1938-1940.
23. Schwan TG, Piesman J, (2000) Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 38: 383-388.
24. Stewart PE, Bestor A, Cullen JN, Rosa PA, (2008) A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle. Infect Immun 76: 1970-1978.
25. Cugini C, Medrano M, Schwan TG, Coburn J, (2003) Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture. Infect Immun 71: 1001-1007.
26. Stevenson B, Schwan TG, Rosa PA, (1995) Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 63: 4535-4539.
27. Coburn J, Cugini C, (2003) Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3. Proc Natl Acad Sci U S A 100: 7301-7306.
28. Marcsisin RA, Campeau SA, Lopez JE, Barbour AG, (2012) AlpA, an arthropod-associated outer membrane protein of Borrelia species that cause relapsing fever. Infect immun 80: 1881-1890.
29. Hovis KM, Jones JP, Sadlon T, Raval G, Gordon DL, et al. (2006) Molecular analyses of the interaction of Borrelia hermsii FhbA with the complement regulatory proteins Factor H and Factor H-like protein 1. Infect Immun 74: 2007-2014.
30. Rossmann E, Kraiczy P, Herzberger P, Skerka C, Kirschfink M, et al. (2007) Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes. J Immunol 178: 7292-7301.
31. Hartmann K, Corvey C, Skerka C, Kirschfink M, Karas M, et al. (2006) Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1. Mol Microbiol 61: 1220-1236.
32. Brissette CA, Haupt K, Barthel D, Cooley AE, Bowman A, et al. (2009) Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. Infect Immun 77: 300-306.
33. Barbour AG, Dai Q, Restrepo BI, Stoenner HG, Frank SA, (2006) Pathogen escape from host immunity by a genome program for antigenic variation. Proc Natl Acad Sci USA 103: 18290-18295.
34. Bono JL, Elias AF, Kupko III JJ, Stevenson B, Tilly K, et al. (2000) Efficient targeted mutagenesis in Borrelia burgdorferi. J Bacteriol 182: 2445-2452.
35. Barbour AG, (1988) Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J Clin Microbiol 26: 475-478.
36. Schwan TG, Karstens RH, Schrumpf ME, Simpson WJ, (1991) Changes in antigenic reactivity of Borrelia burgdorferi, the Lyme disease spirochete, during persistent infection in mice. Can J Microbiol 37: 450-454.
37. Davis GE, (1943) Relapsing fever: the tick Ornithodoros turicata as a spirochetal reservoir. Pub Health Rep 58: 839-842.
38. Whitney MS, Schwan TG, Sultemeier KB, McDonald PS, Brillhart MN, (2007) Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas. Vet Clin Pathol 36: 212-216.
39. Adeyeye OA, Butler JF, (1989) Population structure and seasonal intra-burrow movement of Ornithodoros turicata (Acari: Argasidae) in gopher tortoise burrows. J Med Entomol 26: 279-283.
40. Rawlings JA, (1995) An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. Tex Med 91: 56-59.
41. Davis H, Vincent JM, Lynch J, (2002) Tick-borne relapsing fever caused by Borrelia turicatae. Pediatr Infect Dis J 21: 703-705.