Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICSI of fertile oocyte donors?

Asian Journal of Andrology

Volumn 15, Issue 6, 2013, Pages 812-818

  Gosálvez, Jaime ^a   Caballero, Pedro ^b   López Fernández, Carmen ^a   Ortega, Leonor ^b   Guijarro, José Andrés ^b   Fernández, José Luís ^c   Johnston, Stephen D ^d   Nuñez Calonge, Rocío ^b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Clinica Tambre   (Spain)

^c GINIBIC Complejo Hospitalario Universitario   (Spain)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

assisted reproductive technology; egg donation; male factor; sperm DNA fragmentation

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DNA REPAIR; EJACULATION; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MALE; OOCYTE DONATION; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PREGNANCY; REPRODUCTION; SENSITIVITY AND SPECIFICITY; SPERMATOZOON MOTILITY;

ADULT; DNA FRAGMENTATION; FEMALE; HUMANS; MALE; OOCYTES; PREGNANCY; SPERM INJECTIONS, INTRACYTOPLASMIC; SPERMATOZOA;

EID: 84887260988     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2013.74     Document Type: Article

References (61)

1. Guzick DS, Overstreet JW, Factor-Litvek P, Brazil CK, Nakajima ST et al. Comparison of sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001; 345: 1388-93.
2. Holt WV. Is quality assurance in semen analysis still really necessary? A spermatologist's viewpoint. Hum Reprod 2005; 20: 2983-6. (Pubitemid 41662643)
3. Lewis SEM. Is sperm evaluation useful in predicting human fertility? Reproduction 2007; 134: 31-40. (Pubitemid 47244836)
4. Schlegel PN. Evaluation of male infertility. Minerva Ginecol 2009; 61: 261-83.
5. Zini A, Libman J. Sperm DNA damage: clinical significance in the era of assisted reproduction. CMAJ 2006; 175: 495-500. (Pubitemid 44492301)
6. Bungum M, Bungum L, Giwercman A. Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility. Asian J Androl 2011; 13: 69-75
7. Gosá lvez J, López-Fernández C, Fernández JL. Sperm Chromatin Dispersion (SCD) test: technical aspects and clinical applications. In: Zini A, Agarwal A, editors. Sperm DNA Damage: Biological and Clinical Applications in Male Infertility and Assisted Reproduction. New York: Springer-Verlag; 2011. p151-70.
8. Spano M, Bonde JP, Hjollund HI, Kolstad HA, Cordelli E et al. Sperm chromatin damage impairs human fertility. The Danish first pregnancy planner study team. Fertil Steril 2000; 73: 43-50. (Pubitemid 30018020)
9. Henkel R, Hajimohammad M, Stalf T, Hoogendijk C, Mehnert C et al. Influence of deoxyribonucleic acid damage on fertilization and pregnancy. Fertil Steril 2004; 81: 965-72. (Pubitemid 38452959)
10. Benchaib M, Lornage J, Mazoyer C, Lejeune H, Salle B et al. Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome. Fertil Steril 2007; 87: 93-100. (Pubitemid 46013863)
11. Bakos HW, Thompson JG, Feil D, Lane M. Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int J Androl 2008; 31: 518-26.
12. Gandini L, Lombardo F, Paoli D, Caruso F, Eleuteri P et al. Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage. Hum Reprod 2004; 19: 1409-17. (Pubitemid 38807716)
13. Virro MR, Kjersten L, Larson-Cook KL, Evenson DP. Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplamic sperm injection cycles. Fertil Steril 2004; 81: 1289-95. (Pubitemid 38609313)
14. Bungum M, Humaidan P, Spano M, Jepson K, Bungum L et al. The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI. Hum Reprod 2004; 19: 1401-8. (Pubitemid 38807715)
15. Castilla JA, Zamora S, Gonzalvo MC, Luna del Castillo JD, Roldan-Nofuentes JA et al. Sperm chromatin structure assay and classical semen parameters: systematic review. RBM Online 2010; 20: 114-24.
16. Zini A, Libman J. Sperm DNA damage: importance in the era of assisted reproduction. Curr Opin Urol 2006; 16: 428-34. (Pubitemid 44624577)
17. Evenson DP, Jost LK, Marshal D, Zinaman MJ, Clegg E et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 1999; 14: 1039-49. (Pubitemid 29176486)
18. Evenson DP, Wixon R. Data analysis of two in vivo fertility studies using Sperm Chromatin Structure Assay-derived DNA fragmentation index vs pregnancy outcome. Fertil Steril 2008; 90: 1229-31.
19. Giwercman A, Lindstedt L, Larsson M, Bungum M, Spano M et al. Sperm chromatin structure assay as an independent predictor of fertility invivo: a case-control study. Int J Androl 2010; 33: e221-7.
20. Payne JF, Raburn DJ, Couchman GM, Price TM, Jamison MG et al. Redefining the relationship between sperm deoxyribonucleic acid fragmentation as measured by the sperm chromatin structure assay and outcomes of assisted reproductive techniques. Fertil Steril 2005; 84: 356-64. (Pubitemid 41125256)
21. Simon L, Castillo J, Oliva R, Lewis SE. Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes. RBM Online 2011; 23: 724-34.
22. Bungum M, Spano M, Humaidan P, Eleuteri P, Rescia M et al. Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive for the outcome of ART. Hum Reprod 2008; 23: 4-10. (Pubitemid 351767324)
23. Li Z, Wang L, Cai J, Huang H. Correlation of sperm DNA damage with IVF and ICSI outcomes: a systematic review and meta-analysis. J Assist Reprod Genet 2006; 23: 367-76. (Pubitemid 44922382)
24. Zini A. Are sperm chromatin and DNA defects relevant in the clinic? Sys Biol Reprod Med 2011; 57: 78-85.
25. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L et al. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 2007; 22: 174-9. (Pubitemid 44942682)
26. Borini A, Tarozzi N, Bizzaro D, Bonu MA, Fava L et al. Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART. Hum Reprod 2006; 21: 2876-81. (Pubitemid 44567001)
27. Zini A, Meriano J, Kader K, Jarvi K, Laskin CA et al. Potential adverse effect of sperm DNA damage on embryo quality after ICSI. Hum Reprod 2005; 20: 3476-80. (Pubitemid 41742530)
28. Zini A, Sigman M. Are tests of sperm DNA damage clinically useful? Pros and cons. J Androl 2009; 30: 219-29.
29. Zini A. Clinical utility of sperm DNA integrity tests. In: Zini A, Agarwal A, editors. Sperm DNA damage: Biological and Clinical Applications in Male Infertility and Assisted Reproduction. New York: Springer-Verlag; 2011. p499-504.
30. Fernández JL, Vélez de la Calle JF, Tamayo M, Cajigal D, Agarwal A et al. Sperm DNA integrity and male infertility: current perspectives. Arch Med Sci 2009; 5: S55-62.
31. Muriel L, Goyanes V, Segrelle E, Gosálvez J, Alvarez J et al. Increased aneuploidy rate in sperm with fragmented DNA as determined by the sperm chromatin dispersion (SCD) test and Fish analysis. J Androl 2007; 28: 38-49. (Pubitemid 46048077)
32. García-Peiró A, Martínez-Heredia J, Oliver-Bonet M, Abad C, Amengua JM et al. Protamine P1/P2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm. Fertil Steril 2011; 95: 105-9.
33. Rodríguez S, Goyanes V, Segrelles E, Blasco M, Gosálvez J et al. Critically short telomeres are associated with sperm DNA fragmentation. Fertil Steril 2005; 84: 843-5. (Pubitemid 41414568)
34. Hansen C, Luben TJ, Sacks JD, Olshan A, Jeffay S et al. The effect of ambient air pollution on sperm quality. Environ Health Perspect 2010; 118: 203-9.
35. Meseguer M, Santiso R, Garrido N, García-Herrero S, Remohí J et al. Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality. Fertil Steril 2011; 95: 124-8.
36. Ashwood-Smith MJ, Edwards RG. DNA repair by oocytes. Mol Hum Reprod 1996; 2: 46-51. (Pubitemid 126717416)
37. Menezo Y Jr, Russo GL, Tosti E, Mouatassim SE, Benkhalifa M. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays. J Assist Reprod Genet 2007; 11: 513-20. (Pubitemid 350231557)
38. Gosálvez J, de la Torre J, López-Fernández C, Pérez-Gutiérrez L, Ortega L et al. DNA fragmentation dynamics in fresh versus frozen thawed plus gradient-isolated human spermatozoa. Syst Biol Reprod Med 2010; 56: 27-36.
39. Gosálvez J, Cortés-Gutierrez E, López- Fernández C, Fernández JL, Caballero P et al. Sperm DNA fragmentation dynamics in fertile donors. Fertil Steril 2009; 92: 170-3.
40. Metz CE. Receiver operating Characteristic analysis: a tool for the quantitative evaluation of observer performance and imaging systems. J Am Coll Radiol 2006; 6: 413-22. (Pubitemid 43775808)
41. Fluss R, Faraggi D, Reiser B. Estimation of the Youden Index and its associated cut off point. Biometrical J 2005; 47: 458-72. (Pubitemid 41229379)
42. Zini A, Finellia A, Phanga D, Jarvia K. Influence of semen processing technique on human sperm DNA integrity. Urology 2000; 56: 1081-4.
43. Enciso M, Iglesias M, Galán I, Sarasa J, Gosálvez A et al. The ability of sperm selection techniques to remove single-or double-strand DNA damage. Asian J Androl 2011; 13: 764-8.
44. Ng FL, Liu DY, Baker HW. Comparison of Percoll, mini-Percoll and swim-up methods for sperm preparation from abnormal semen samples. Hum Reprod 1992; 7: 261-6.
45. Sakkas D, Manicardi GC, Tomlinson M, Mandrioli M, Bizzaro D et al. The use of two density gradient centrifugation techniques and the swim-up method to separate spermatozoa with chromatin and nuclear DNA anomalies. Hum Reprod 2000; 15: 1112-6. (Pubitemid 30251310)
46. Mortimer D. Sperm preparation techniques and iatrogenic failures of in-vitro fertilization. Hum Reprod 1991; 6: 173-6.
47. Tampaichitr N, Agulnik A, Seibel M, Taymor M. Comparison of the in vitro fertilization rate by human sperm capacitated by multiple-tube swim-up and Percoll gradient centrifugation. J In Vitro Fert Embryo Transf 1988; 5: 119-22.
48. Santiso R, Tamayo M, Gosálvez J, Meseguer M, Garrido N et al. Swim-up procedure selects spermatozoa with longer telomere length. Mut Res 2010; 688: 88-90.
49. Huszar G, Ozenci CC, Cayli S, Zavaczki Z, Hansch E et al. Hyaluronic acid binding by human sperm indicates cellular maturity, viability, and unreacted acrosomal status. Fertil Steril 2003; 79: 1616-24. (Pubitemid 36687941)
50. Eltes F, Yaari S, Katz N, Barr I, Fishman A et al. The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm. Hum Reprod 2005; 20: 185-90.
51. Said TM, Agarwal A, Grunewald S, Rasch M, Glander HJ et al. Evaluation of sperm recovery following annexin V magnetic-activated cell sorting separation. RBM Online 2006; 13: 336-9. (Pubitemid 44375411)
52. Sun JG, Jurisicova A, Casper RF. Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod 1997; 56: 602-7. (Pubitemid 27084094)
53. Lopes S, Sun JG, Jurisicova A, Meriano J, Casper RF. Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril 1998; 69: 528-32.
54. Henkel R, Kierspel E, Stalf T, Mehnert C, Menkveld R. Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non leukocytospermic patients. Fertil Steril 2005; 83: 635-42. (Pubitemid 40348575)
55. Benchaib M, Braun V, Lornage J, Hadj S, Salle B et al. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod 2003; 18: 1023-8. (Pubitemid 36592045)
56. Muriel L, Meseguer M, Fernández JL, Álvarez J, Remohí J et al. Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study. Hum Reprod 2006; 21: 738-44. (Pubitemid 43372981)
57. Velez de la Calle JF, Muller A, Walschaerts M, Clavere JL, Jimenez C et al. Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproductive technology programs: results of a large prospective multicenter study. Fertil Steril 2008; 90: 1792-9.
58. Evenson D, Jost L. Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 2000; 22: 169-89. (Pubitemid 32218769)
59. Evenson DP, Larson KJ, Jost LK. Sperm Chromatin Structure Assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002; 23: 25-43. (Pubitemid 34001126)
60. Álvarez JG. The predictive value of sperm chromatin structure assay. Hum Reprod 2005; 20: 2365-7. (Pubitemid 41418536)
61. Santiso R, Tamayo M, Gosá lvez J, Johnston S, Mariño A et al. DNA fragmentation dynamics allows the assessment of cryptic sperm damage in human: evaluation of exposure to ionizing radiation, hyperthermia, acidic pH and nitric oxide. Mutat Res 2012; 734: 41-9.