Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients

Resuscitation

Volumn 84, Issue 12, 2013, Pages 1728-1733

  Salciccioli, Justin D ^a   Cocchi, Michael N ^a   Rittenberger, Jon C ^b   Peberdy, Mary Ann ^c   Ornato, Joseph P ^c   Abella, Benjamin S ^d   Gaieski, David F ^d   Clore, John ^c   Gautam, Shiva ^a   Giberson, Tyler ^a   Callaway, Clifton W ^b   Donnino, Michael W ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cardiac arrest; Lactic acidosis; Neuromuscular blockade; OHCA; Shock

Indexed keywords

LACTIC ACID; NEUROMUSCULAR BLOCKING AGENT;

ADULT; AGED; ARTICLE; BLOOD PH; CARDIAC PATIENT; CARDIOVASCULAR MORTALITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMATOSE PATIENT; CONTROLLED STUDY; FEMALE; FUNCTIONAL STATUS; HOSPITAL DISCHARGE; HUMAN; INDUCED HYPOTHERMIA; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROMUSCULAR BLOCKING; OBSERVATIONAL STUDY; OUT OF HOSPITAL CARDIAC ARREST; OUTCOME ASSESSMENT; OVERALL SURVIVAL; OXYGENATION; POST HOC ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETURN OF SPONTANEOUS CIRCULATION; SURVIVAL RATE;

CARDIAC ARREST; LACTIC ACIDOSIS; NEUROMUSCULAR BLOCKADE; OHCA; SHOCK;

ACIDOSIS, LACTIC; ADULT; AGED; FEMALE; HUMANS; LACTATES; MALE; MIDDLE AGED; NEUROMUSCULAR BLOCKADE; OUT-OF-HOSPITAL CARDIAC ARREST; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84887244440     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2013.06.008     Document Type: Article

References (30)

1. Garza A.G., Gratton M.C., Salomone J.A., Lindholm D., McElroy J., Archer R. Improved patient survival using a modified resuscitation protocol for out-of-hospital cardiac arrest. Circulation 2009, 119:2597-2605.
2. Nichol G., Thomas E., Callaway C.W., et al. Regional variation in out-of-hospital cardiac arrest incidence and outcome. J Am Med Assoc 2008, 300:1423-1431.
3. Laver S., Farrow C., Turner D., Nolan J. Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 2004, 30:2126-2128.
4. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556.
5. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Eng J Med 2002, 346:557-563.
6. Nielsen N., Sunde K., Hovdenes J., et al. Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia. Crit Care Med 2011, 39:57-64.
7. Papazian L., Forel J.M., Gacouin A., et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010, 363:1107-1116.
8. Slutsky A.S. Neuromuscular blocking agents in ARDS. N Engl J Med 2010, 363:1176-1180.
9. Forel J.M., Roch A., Marin V., et al. Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med 2006, 34:2749-2757.
10. Chamorro C., Borrallo J.M., Romera M.A., Silva J.A., Balandin B. Anesthesia and analgesia protocol during therapeutic hypothermia after cardiac arrest: a systematic review. Anesth Analg 2010, 110:1328-1335.
11. Peberdy M.A., Callaway C.W., Neumar R.W., et al. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122:S768-S786.
12. Adrie C., Cariou A., Mourvillier B., et al. Predicting survival with good neurological recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA score. Eur Heart J 2006, 27:2840-2845.
13. Hunziker S., Bivens M.J., Cocchi M.N., et al. International validation of the out-of-hospital cardiac arrest score in the United States. Crit Care Med 2011, 39:1670-1674.
14. Lai S.M., Duncan P.W. Stroke recovery profile and the Modified Rankin assessment. Neuroepidemiology 2001, 20:26-30.
15. van Alem A.P., de Vos R., Schmand B., Koster R.W. Cognitive impairment in survivors of out-of-hospital cardiac arrest. Am Heart J 2004, 148:416-421.
16. Stiell I.G., Nichol G., Leroux B.G., et al. Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest. N Engl J Med 2011, 365:787-797.
17. Gainnier M., Roch A., Forel J.M., et al. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med 2004, 32:113-119.
18. Donnino M., Salciccioli J., Gaieski D., et al. Lactate clearance is associated with improved survival and neurological outcome in post-cardiac arrest. Circulation 2012, 126:A38.
19. Donnino M.W., Miller J., Goyal N., et al. Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation 2007, 75:229-234.
20. Kliegel A., Losert H., Sterz F., et al. Serial lactate determinations for prediction of outcome after cardiac arrest. Medicine (Baltimore) 2004, 83:274-279.
21. Nguyen H.B., Rivers E.P., Knoblich B.P., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32:1637-1642.
22. Abramson D., Scalea T.M., Hitchcock R., Trooskin S.Z., Henry S.M., Greenspan J. Lactate clearance and survival following injury. J Trauma 1993, 35:584-588. discussion 588-589.
23. Blow O., Magliore L., Claridge J.A., Butler K., Young J.S. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24h improves outcome from major trauma. J Trauma 1999, 47:964-969.
24. Jacobi J., Fraser G.L., Coursin D.B., et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002, 30:119-141.
25. Rhoney D.H., Murry K.R. National survey of the use of sedating drugs, neuromuscular blocking agents, and reversal agents in the intensive care unit. J Intensive Care Med 2003, 18:139-145.
26. Polderman K.H. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med 2009, 37:S186-S202.
27. Belliard G., Catez E., Charron C., et al. Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation. Resuscitation 2007, 75:252-259.
28. Castrejon S., Cortes M., Salto M.L., et al. Improved prognosis after using mild hypothermia to treat cardiorespiratory arrest due to a cardiac cause: comparison with a control group. Rev Esp Cardiol 2009, 62:733-741.
29. Gooch J.L., Suchyta M.R., Balbierz J.M., Petajan J.H., Clemmer T.P. Prolonged paralysis after treatment with neuromuscular junction blocking agents. Crit Care Med 1991, 19:1125-1131.
30. Segredo V., Caldwell J.E., Matthay M.A., Sharma M.L., Gruenke L.D., Miller R.D. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med 1992, 327:524-528.