Effects of 5-HT1A receptor stimulation on striatal and cortical M1 pERK induction by l-DOPA and a D1 receptor agonist in a rat model of Parkinson's disease

Brain Research

Volumn 1537, Issue , 2013, Pages 327-339

  Lindenbach, David ^a   Dupre, Kristin B ^a   Eskow Jaunarajs, Karen L ^a   Ostock, Corinne Y ^a   Goldenberg, Adam A ^a   Bishop, Christopher ^a  

^a BINGHAMTON UNIVERSITY   (United States)

Author keywords

Dopamine; Extracellular regulated kinase; Motor cortex; Parkinson's disease; Serotonin; Striatum

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; LEVODOPA; OXIDOPAMINE; PHOSPHORYLATED EXTRACELLULAR REGULATED KINASE; PHOSPHOTRANSFERASE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ACUTE DRUG ADMINISTRATION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DYSKINESIA; ENZYME ACTIVATION; ENZYME INDUCTION; FOREFOOT; FORELIMB; LONG TERM CARE; MALE; MOTOR PERFORMANCE; NONHUMAN; PARKINSON DISEASE; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; UPREGULATION;

ANIMALIA; RATTUS;

5-HT; 5-HT(1A)R; 6-HYDROXYDOPAMINE; 6-OHDA; ABNORMAL INVOLUNTARY MOVEMENTS; AIMS; D(1) RECEPTOR; D(1)R; DA; DOPAMINE; DPAT; ERK; EXTRACELLULAR-REGULATED KINASE; L-DOPA-INDUCED DYSKINESIA; LID; M.A.D.; M1; MEDIAN ABSOLUTE DEVIATION; MOTOR CORTEX; PARKINSON'S DISEASE; PD; PERK; PHOSPHORYLATED EXTRACELLULAR-REGULATED KINASE; PRIMARY MOTOR CORTEX; S.E.M.; SCH; SCH23390; SEROTONIN; SEROTONIN 1A RECEPTOR; SKF; SKF81297; STANDARD ERROR OF THE MEAN; STRIATUM; VEH; VEHICLE; ±8-OH-DPAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LEVODOPA; MALE; MAP KINASE SIGNALING SYSTEM; PARKINSON DISEASE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D1; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN RECEPTOR AGONISTS;

EID: 84887243392     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.09.020     Document Type: Article

References (39)

1. J.E. Ahlskog, and M.D. Muenter Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature Mov. Disord. 16 2001 448 458
2. B.W. Balleine, M.R. Delgado, and O. Hikosaka The role of the dorsal striatum in reward and decision-making J. Neurosci. 27 2007 8161 8165
3. F. Bibbiani, J.D. Oh, and T.N. Chase Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models Neurology 57 2001 1829 1834
4. J. Buritova, G. Berrichon, C. Cathala, F. Colpaert, and D. Cussac Region-specific changes in 5-HT1A agonist-induced extracellular signal-regulated kinases 1/2 phosphorylation in rat brain: a quantitative ELISA study Neuropharmacology 56 2009 350 361
5. Cenci, M.A., Lundblad, M., 2007. Ratings of l-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice. Current Protocols in Neuroscience (Chapter 9: Unit 25).
6. M.A. Cenci, K.E. Ohlin, and P. Odin Current options and future possibilities for the treatment of dyskinesia and motor fluctuations in Parkinson's disease CNS Neurol. Disord. Drug Targets 10 2011 670 684
7. J.W. Chang, S.R. Wachtel, D. Young, and U.J. Kang Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions Neuroscience 88 1999 617 628
8. J. Chen, C. Shen, and E. Meller 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain Eur. J. Pharmacol. 452 2002 155 162
9. Y. Ding, L. Won, J.P. Britt, S.A. Lim, D.S. McGehee, and U.J. Kang Enhanced striatal cholinergic neuronal activity mediates l-DOPA-induced dyskinesia in parkinsonian mice Proc. Natl. Acad. Sci. USA 108 2011 840 845
10. K.B. Dupre, K.L. Eskow, G. Negron, and C. Bishop The differential effects of 5-HT1A receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat, Brain Res. Brain. Res. 1158 2007 135 143
11. K.B. Dupre, K.L. Eskow, C.J. Barnum, and C. Bishop Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat Neuropharmacology 55 2008 1321 1328
12. K.B. Dupre, C.Y. Ostock, K.L. Eskow Jaunarajs, T. Button, L.M. Savage, W. Wolf, and C. Bishop Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rat Exp. Neurol. 229 2011 288 299
13. K.B. Dupre, C.Y. Ostock, J.A. George, K.L. Eskow Jaunarajs, C.M. Hueston, and C. Bishop Effects of 5-HT receptor stimulation on D1 receptor agonist-induced striatonigral activity and dyskinesia in hemiparkinsonian rats ACS Chem. Neurosci. 4 2013 747 760
14. K.L. Eskow, V. Gupta, S. Alam, J.Y. Park, and C. Bishop The partial 5-HT1A agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy Pharmacol. Biochem. Behav. 87 2007 306 314
15. S. Fasano, E. Bezard, A. D'Antoni, V. Francardo, M. Indrigo, L. Qin, S. Dovero, M. Cerovic, M.A. Cenci, and R. Brambilla Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa-induced dyskinesia Proc. Natl. Acad. Sci. USA 107 2010 21824 21829
16. M. Feyder, A. Bonito-Oliva, and G. Fisone l-DOPA-induced dyskinesia and abnormal signaling in striatal medium spiny neurons: focus on dopamine D1 receptor-mediated transmission Front. Behav. Neurosci. 5 2011 1 11
17. D. Frechilla, A. Cobreros, L. Saldise, R. Moratalla, R. Insausti, M. Luquin, and J. Del Rio Serotonin 5-HT(1A) receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys Synapse 39 2001 288 296
18. M.N. Garnovskaya, T. van Biesen, B. Hawe, S. Casanas Ramos, R.J. Lefkowitz, and J.R. Raymond Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway Biochemistry 35 1996 13716 13722
19. C.R. Gerfen, S. Miyachi, R. Paletzki, and P. Brown D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase J. Neurosci. 22 2002 5042 5054
20. S. Geyer, M. Matelli, G. Luppino, and K. Zilles Functional neuroanatomy of the primate isocortical motor system Anat. Embryol. 202 2000 443 474
21. P. Huot, T.H. Johnston, J.B. Koprich, L. Winkelmolen, S.H. Fox, and J.M. Brotchie Regulation of cortical and striatal 5-HT1A receptors in the MPTP-lesioned macaque Neurobiol. Aging 33 2012 9 19
22. M. Inden, M. Abe, H. Minamino, K. Takata, K. Yoshimoto, I. Tooyama, and Y. Kitamura Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on l-DOPA-induced rotational behavior in a hemiparkinsonian rat model J. Pharmacol. Sci. 119 2012 10 19
23. P. Jenner Molecular mechanisms of l-DOPA-induced dyskinesia Nat. Rev. Neurosci. 9 2008 665 677
24. D.S. Kim, R.D. Palmiter, A. Cummins, and C.R. Gerfen Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice Neuroscience 137 2006 1381 1388
25. D. Lindenbach, C.Y. Ostock, K.L. Eskow Jaunarajs, K.B. Dupre, C.J. Barnum, N. Bhide, and C. Bishop Behavioral and cellular modulation of l-DOPA-induced dyskinesia by β-adrenoceptor blockade in the 6-hydroxydopamine-lesioned rat J. Pharmacol. Exp. Ther. 337 2011 755 765
26. H.S. Lindgren, K.E. Ohlin, and M.A. Cenci Differential involvement of D1 and D2 dopamine receptors in l-DOPA-induced angiogenic activity in a rat model of Parkinson's disease Neuropsychopharmacology 34 2009 2477 2488
27. S.T. Papadeas, B.L. Blake, D.J. Knapp, and G.R. Breese Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement J. Neurosci. 24 2004 5863 5876
28. N. Pavon, A.B. Martin, A. Mendialdua, and R. Moratalla ERK phosphorylation and FosB expression are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice Biol. Psychiatry 59 2006 64 74
29. G. Paxinos, and W. Watson The Rat Brain in Stereotaxic Coordinates fourth ed. 1998 Academic Press San Diego
30. B. Picconi, D. Centonze, K. Håkansson, G. Bernardi, P. Greengard, G. Fisone, M.A. Cenci, and P. Calabresi Loss of bidirectional striatal synaptic plasticity in l-DOPA-induced dyskinesia Nat. Neurosci. 6 2003 501 506
31. J.R. Raymond, Y.V. Mukhin, T.W. Gettys, and M.N. Garnovskaya The recombinant 5-HT1A receptor: G protein coupling and signalling pathways Br. J. Pharmacol. 127 1999 1751 1764
32. E. Santini, E. Valjent, A. Usiello, M. Carta, A. Borgkvist, J.A. Girault, D. Herve, P. Greengard, and G. Fisone Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia J. Neurosci. 27 2007 6995 7005
33. E. Santini, E. Valjent, and G. Fisone Parkinson's disease: levodopa-induced dyskinesia and signal transduction FEBS J. 275 2008 1392 1399
34. E. Santini, C. Alcacer, S. Cacciatore, M. Heiman, D. Hervé, P. Greengard, J.-A. Girault, E. Valjent, and G. Fisone l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice J. Neurochem. 108 2009 621 633
35. E. Santini, V. Sgambato-Faure, Q. Li, M. Savasta, S. Dovero, G. Fisone, and E. Bezard Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in l-DOPA-induced dyskinesia PLoS One 5 2010 e12322
36. M.W. Shiflett, and B.W. Balleine Contributions of ERK signaling in the striatum to instrumental learning and performance Behav. Brain Res. 218 2011 240 247
37. G.M. Thomas, and R.L. Huganir MAPK cascade signalling and synaptic plasticity Nat. Rev. Neurosci. 5 2004 173 183
38. V. Voon, P.O. Fernagut, J. Wickens, C. Baunez, M. Rodriguez, N. Pavon, J.L. Juncos, J.A. Obeso, and E. Bezard Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders Lancet Neurol. 8 2009 1140 1149
39. J.E. Westin, L. Vercammen, E.M. Strome, C. Konradi, and M.A. Cenci Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of l-DOPA-induced dyskinesia and the role of dopamine D1 receptors Biol. Psychiatry 62 2007 800 810