메뉴 건너뛰기




Volumn 119, Issue 1, 2012, Pages 10-19

Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model

Author keywords

6 Hydroxydopamine; Fluoxetine; L dihydroxyphenylalanine; Parkinson's disease; Selective serotonin reuptake inhibitor

Indexed keywords

FLUOXETINE; HISTONE H3; LEVODOPA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; OXIDOPAMINE; SEROTONIN 1A RECEPTOR; TRYPTOPHAN HYDROXYLASE; TYROSINE 3 MONOOXYGENASE;

EID: 84861468507     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12003FP     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 0014930392 scopus 로고
    • L-DOPA-induced release of cerebral monoamines
    • Ng KY, Colburn RW, Kopin IJ. L-DOPA-induced release of cerebral monoamines. Science. 1970;170:76-77.
    • (1970) Science , vol.170 , pp. 76-77
    • Ng, K.Y.1    Colburn, R.W.2    Kopin, I.J.3
  • 3
    • 0028568077 scopus 로고
    • Immuno-histochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase
    • Arai R, Karasawa N, Geffard M, Nagatsu T, Nagatsu I. Immuno-histochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase. Brain Res. 1994;667:295-299.
    • (1994) Brain Res , vol.667 , pp. 295-299
    • Arai, R.1    Karasawa, N.2    Geffard, M.3    Nagatsu, T.4    Nagatsu, I.5
  • 4
    • 20144378889 scopus 로고    scopus 로고
    • Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered L-DOPA
    • DOI 10.1016/j.brainres.2005.04.019, PII S0006899305005548
    • Maeda T, Nagata K, Yoshida Y, Kannari K. Serotonergic hyperin-nervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered 1-DOPA. Brain Res. 2005;1046:230-233. (Pubitemid 40775894)
    • (2005) Brain Research , vol.1046 , Issue.1-2 , pp. 230-233
    • Maeda, T.1    Nagata, K.2    Yoshida, Y.3    Kannari, K.4
  • 5
    • 34447627504 scopus 로고    scopus 로고
    • Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats
    • DOI 10.1093/brain/awm082
    • Carta M, Carlsson T, KiriK D, Björklund A. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain. 2007;130:1819-1833. (Pubitemid 47343795)
    • (2007) Brain , vol.130 , Issue.7 , pp. 1819-1833
    • Carta, M.1    Carlsson, T.2    Kirik, D.3    Bjorklund, A.4
  • 6
    • 58149107401 scopus 로고    scopus 로고
    • Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
    • Munoz A, Li Q, Gardoni F, Marcello E, Qin C, Carlsson T, et al. Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain. 2008;131:3380-3394.
    • (2008) Brain , vol.131 , pp. 3380-3394
    • Munoz, A.1    Li, Q.2    Gardoni, F.3    Marcello, E.4    Qin, C.5    Carlsson, T.6
  • 7
    • 34547484764 scopus 로고    scopus 로고
    • Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    • DOI 10.1523/JNEUROSCI.2079-07.2007
    • Carlsson T, Carta M, Winkler C, Björklund A, Kirik D. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. J Neurosci. 2007;27:8011-8022. (Pubitemid 47173327)
    • (2007) Journal of Neuroscience , vol.27 , Issue.30 , pp. 8011-8022
    • Carlsson, T.1    Carta, M.2    Winkler, C.3    Bjorklund, A.4    Kirik, D.5
  • 8
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Diagnosis and management
    • DOI 10.1016/S1474-4422(06)70373-8, PII S1474442206703738
    • Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 2006;5:235-245. (Pubitemid 43238347)
    • (2006) Lancet Neurology , vol.5 , Issue.3 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.V.3
  • 9
    • 26244458417 scopus 로고    scopus 로고
    • Current approaches to management of depression in Parkinson's Disease
    • DOI 10.1016/j.jocn.2005.03.008, PII S096758680500144X
    • Vajda FJ, Solinas C. Current approaches to management of depression in Parkinson's disease. J Clin Neurosci. 2005;12: 739-743. (Pubitemid 41411876)
    • (2005) Journal of Clinical Neuroscience , vol.12 , Issue.7 , pp. 739-743
    • Vajda, F.J.E.1    Solinas, C.2
  • 10
    • 41349108253 scopus 로고    scopus 로고
    • Parkinson's disease - Part 3: Neuropsychiatric symptoms
    • Weintraub D, Comella CL, Horn S. Parkinson's disease - Part 3: Neuropsychiatric symptoms. Am J Manag Care. 2008; 14 (2 Suppl):S59-S69.
    • (2008) Am J Manag Care , vol.14 , Issue.2 SUPPL.
    • Weintraub, D.1    Comella, C.L.2    Horn, S.3
  • 11
    • 84861474572 scopus 로고    scopus 로고
    • Start of a selective serotonin reuptake inhibitor (SSRI) and increase of antiparkinsonian drug treatment in patients on levodopa
    • van de Vijver DA, Roos RA, Jansen PA, Porsius AJ, de Boer A. Start of a selective serotonin reuptake inhibitor (SSRI) and increase of antiparkinsonian drug treatment in patients on levodopa. Br J Clin Pharmacol. 2002;26:142-145.
    • (2002) Br J Clin Pharmacol , vol.26 , pp. 142-145
    • Van De Vijver, D.A.1    Roos, R.A.2    Jansen, P.A.3    Porsius, A.J.4    De Boer, A.5
  • 12
  • 13
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
    • Ungerstedt U, Arbuthnott GW. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res. 1970;24:485-493.
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.W.2
  • 14
    • 0036283426 scopus 로고    scopus 로고
    • Modeling Parkinson's disease in rats: An evaluation of 6-OHDA lesions of the nigrostriatal pathway
    • DOI 10.1006/exnr.2002.7891
    • Deumens R, Blokland A, Prickaerts J. Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol. 2002;175:303-317. (Pubitemid 34634286)
    • (2002) Experimental Neurology , vol.175 , Issue.2 , pp. 303-317
    • Deumens, R.1    Blokland, A.2    Prickaerts, J.3
  • 16
    • 0037439079 scopus 로고    scopus 로고
    • Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa
    • van Kampen JM, Stoess AJ. Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa. Neuroscience. 2003;116:307-314.
    • (2003) Neuroscience , vol.116 , pp. 307-314
    • Van Kampen, J.M.1    Stoess, A.J.2
  • 17
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signalling and synaptic plasticity
    • Thomas H, Huganir RL. MAPK cascade signaling and synaptic plasticity. Nat Rev Neurosci. 2004;5:173-183. (Pubitemid 38252474)
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.3 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 18
    • 29344434297 scopus 로고    scopus 로고
    • ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice
    • DOI 10.1016/j.biopsych.2005.05.044, PII S0006322305007079
    • Pavon N, Martin AB, Mendialdua A, Moratalla R. ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Biol Psychiatry. 2006;59:64-74. (Pubitemid 43005237)
    • (2006) Biological Psychiatry , vol.59 , Issue.1 , pp. 64-74
    • Pavon, N.1    Martin, A.B.2    Mendialdua, A.3    Moratalla, R.4
  • 20
    • 58149333252 scopus 로고    scopus 로고
    • L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
    • Santini E, Alcacer C, Cacciatore S, Heiman M, Hervé D, Greengard P, et al. L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. J Neurochem. 2009;108:621-633.
    • (2009) J Neurochem , vol.108 , pp. 621-633
    • Santini, E.1    Alcacer, C.2    Cacciatore, S.3    Heiman, M.4    Hervé, D.5    Greengard, P.6
  • 21
    • 0035826913 scopus 로고    scopus 로고
    • Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum
    • Yamato H, Kannari K, Shen H, Suda T, Matsunaga M. Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum. Neuroreport. 2001;12:1123-1126. (Pubitemid 32374729)
    • (2001) NeuroReport , vol.12 , Issue.6 , pp. 1123-1126
    • Yamato, H.1    Kannari, K.2    Shen, H.3    Suda, T.4    Matsunaga, M.5
  • 23
    • 0038182524 scopus 로고    scopus 로고
    • MSK2 and MSK1 mediate the mitogen and stress-induced phosphorylation of histone H3 and HMG-14
    • Soloaga A, Thomson S, Wiggin GR, Rampersaund N, Dyson MH, Hazzakin CA, et al. MSK2 and MSK1 mediate the mitogen and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 2003;22:2788-2797.
    • (2003) EMBO J , vol.22 , pp. 2788-2797
    • Soloaga, A.1    Thomson, S.2    Wiggin, G.R.3    Rampersaund, N.4    Dyson, M.H.5    Hazzakin, C.A.6
  • 24
    • 0019160120 scopus 로고
    • Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in Parkinsonism
    • DOI 10.1002/ana.410080603
    • Melamed E, Hefti F, Wurtman RJ. Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in parkinsonism. Ann Neurol. 1980;8:558-563. (Pubitemid 11213498)
    • (1980) Annals of Neurology , vol.8 , Issue.6 , pp. 558-563
    • Melamed, E.1    Hefti, F.2    Wurtman, R.J.3
  • 26
    • 0033601926 scopus 로고    scopus 로고
    • Role of serotonergic neuron in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats
    • Tanaka H, Kannari K, Maeda T, Tomiyama M, Sudo T, Matsunaga M. Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats. Neuroreport. 1999;10:631-634. (Pubitemid 29333295)
    • (1999) NeuroReport , vol.10 , Issue.3 , pp. 631-634
    • Tanaka, H.1    Kannari, K.2    Maeda, T.3    Tomiyama, M.4    Suda, T.5    Matsunaga, M.6
  • 27
    • 79960098724 scopus 로고    scopus 로고
    • Serotonin innervation of basal ganglia in monkeys and humans
    • Parent M, Wallman MJ, Gagnon D, Parent A. Serotonin innervation of basal ganglia in monkeys and humans. J Chem Neuroanat. 2011;41:256-265.
    • (2011) J Chem Neuroanat , vol.41 , pp. 256-265
    • Parent, M.1    Wallman, M.J.2    Gagnon, D.3    Parent, A.4
  • 28
    • 79954563661 scopus 로고    scopus 로고
    • Serotonin innervation of human basal ganglia
    • Wallman MJ, Gagnon D, Parent M. Serotonin innervation of human basal ganglia. Eur J Neurosci. 2011;33:1519-1532.
    • (2011) Eur J Neurosci , vol.33 , pp. 1519-1532
    • Wallman, M.J.1    Gagnon, D.2    Parent, M.3
  • 29
    • 33846426067 scopus 로고    scopus 로고
    • Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
    • DOI 10.1016/j.pharmthera.2006.08.004, PII S0163725806001525
    • Alex KD, Pehek EA. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther. 2007;113:296-320. (Pubitemid 46149046)
    • (2007) Pharmacology and Therapeutics , vol.113 , Issue.2 , pp. 296-320
    • Alex, K.D.1    Pehek, E.A.2
  • 30
    • 80052834174 scopus 로고    scopus 로고
    • The serotonergic system in Parkinson's disease
    • Huot P, Fox SH, Brotchie JM. The serotonergic system in Parkinson's disease. Prog Neurobiol. 2011;95:163-212.
    • (2011) Prog Neurobiol , vol.95 , pp. 163-212
    • Huot, P.1    Fox, S.H.2    Brotchie, J.M.3
  • 31
    • 0027163303 scopus 로고
    • 5-HT and antidepressants: New views from microdialysis studies [1]
    • Artigas F. 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol Sci. 1993;14:262. (Pubitemid 23204242)
    • (1993) Trends in Pharmacological Sciences , vol.14 , Issue.7 , pp. 262
    • Artigas, F.1
  • 32
    • 0024477717 scopus 로고
    • 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis
    • Sharp T, Bramwell SR, Grahame-Smith DG. 5-HT1 agonists reduce 6-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol. 1989;96: 283-290 (Pubitemid 19045101)
    • (1989) British Journal of Pharmacology , vol.96 , Issue.2 , pp. 283-290
    • Sharp, T.1    Bramwell, S.R.2    Grahame-Smith, D.G.3
  • 33
    • 0030696650 scopus 로고    scopus 로고
    • The effect of the selective 5-HT(1A) agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain
    • DOI 10.1038/sj.bjp.0701420
    • Casanovas JM, Lesourd M, Artigas F. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. Br J Pharmacol. 1997;122:733-741. (Pubitemid 27453100)
    • (1997) British Journal of Pharmacology , vol.122 , Issue.4 , pp. 733-741
    • Casanovas, J.M.1    Lesourd, M.2    Artigas, F.3
  • 34
    • 67651017881 scopus 로고    scopus 로고
    • Physiology and pharmacology of striatal neurons
    • Kreitzer AC. Physiology and pharmacology of striatal neurons. Annu Rev Neurosci. 2009;32:127-147.
    • (2009) Annu Rev Neurosci , vol.32 , pp. 127-147
    • Kreitzer, A.C.1
  • 35
    • 68949172388 scopus 로고    scopus 로고
    • Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation
    • Darmopil S, Martin AB, De Diego IR, Ares S, Moratalla R. Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. Biol Psychiatry. 2009;66:603-613.
    • (2009) Biol Psychiatry , vol.66 , pp. 603-613
    • Darmopil, S.1    Martin, A.B.2    De Diego, I.R.3    Ares, S.4    Moratalla, R.5
  • 36
    • 2942598295 scopus 로고    scopus 로고
    • Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias
    • DOI 10.1016/j.bbr.2003.10.009, PII S0166432803003735
    • Delfino MA, Stefano AV, Ferrario JE, Taravini IR, Murer MG, Gershanik OS. Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias. Behav Brain Res. 2004;152:297-306. (Pubitemid 38757900)
    • (2004) Behavioural Brain Research , vol.152 , Issue.2 , pp. 297-306
    • Delfino, M.A.1    Stefano, A.V.2    Ferrario, J.E.3    Taravini, I.R.E.4    Murer, M.G.5    Gershanik, O.S.6
  • 37
    • 28144463965 scopus 로고    scopus 로고
    • Validation of the L-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists
    • DOI 10.1016/j.brainresbull.2004.10.011, PII S0361923004002758
    • Monville C, Torres EM, Dunnett SB. Validation of the L-DOPA-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists. Brain Res Bull. 2005;68:16-23. (Pubitemid 41698872)
    • (2005) Brain Research Bulletin , vol.68 , Issue.1-2 , pp. 16-23
    • Monville, C.1    Torres, E.M.2    Dunnett, S.B.3
  • 38
    • 23944489551 scopus 로고    scopus 로고
    • 2 receptor contributions to L-DOPA-induced dyskinesia in the dopamine-depleted rat
    • DOI 10.1016/j.pbb.2005.06.013, PII S0091305705002169
    • Taylor JL, Bishop C, Walker PD. Dopamine D1 and D2 receptor contributions to L-DOPA-induced dyskinesia in the dopamine-depleted rat. Pharmacol Biochem Behav. 2005;81:887-893. (Pubitemid 41187824)
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , Issue.4 , pp. 887-893
    • Taylor, J.L.1    Bishop, C.2    Walker, P.D.3
  • 39
    • 34047178328 scopus 로고    scopus 로고
    • Spatiotemporal Pattern of Striatal ERK1/2 Phosphorylation in a Rat Model of L-DOPA-Induced Dyskinesia and the Role of Dopamine D1 Receptors
    • DOI 10.1016/j.biopsych.2006.11.032, PII S0006322306015514, Molecular Mechanisms, Brain Development, and Novel Treatment Mechanisms for Schizophrenia
    • Westin JE, Vercammen L, Strome EM, Konradi C, Cenci MA. Spatiotemporal pattern of striatal ERM1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biol Psychiatry. 2007;62:800-810. (Pubitemid 47374647)
    • (2007) Biological Psychiatry , vol.62 , Issue.7 , pp. 800-810
    • Westin, J.E.1    Vercammen, L.2    Strome, E.M.3    Konradi, C.4    Cenci, M.A.5
  • 40
    • 44849131472 scopus 로고    scopus 로고
    • Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat
    • DOI 10.1002/syn.20527
    • Carta AR, Frau L, Pinna A, Pontis S, Simola N, Schintu N, et al. Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat. Synapse. 2008;62:524-533. (Pubitemid 351794179)
    • (2008) Synapse , vol.62 , Issue.7 , pp. 524-533
    • Carta, A.R.1    Lucia, F.2    Annalisa, P.3    Silvia, P.4    Nicola, S.5    Nicoletta, S.6    Micaela, M.7
  • 41
    • 0029945376 scopus 로고    scopus 로고
    • Dyskinesias and tolerance induced by chronic treatment with a D1 agonist administered in pulsatile or continuous mode do not correlate with changes of putaminal D1 receptors in drug-naive MPTP monkeys
    • DOI 10.1016/0006-8993(96)00157-6
    • Goulet M, Grondin R, Blanchet PJ, Bedard PJ, Di Paolo T. Dyskinesias and tolerance induced by chronic treatment with a D1 agonist administered in pulsatile or continuous mode do not correlate with changes of putaminal D1 receptors in drug-naïve MPTP monkeys. Brain Res. 1996;719:129-137. (Pubitemid 26173384)
    • (1996) Brain Research , vol.719 , Issue.1-2 , pp. 129-137
    • Goulet, M.1    Grondin, R.2    Blanchet, P.J.3    Bedard, P.J.4    Di, P.T.5
  • 42
    • 0033009422 scopus 로고    scopus 로고
    • Chronic D1 and D2 dopaminomimetic treatment of MPTP-denervated monkeys: Effects on basal ganglia GABA(A)/benzodiazepine receptor complex and GABA content
    • DOI 10.1016/S0197-0186(99)00064-9, PII S0197018699000649
    • Calon F, Morissette M, Goulet M, Grondin R, Blanchet PJ, Bedard PJ, et al. Chronic D1 and D2 dopaminomimetic of MPTP-denervated monkeys: effects on basal ganglia GABA(A)/ benzodiazepine receptor complex and GABA content. Neurochem Int. 1999;35:81-91. (Pubitemid 29251232)
    • (1999) Neurochemistry International , vol.35 , Issue.1 , pp. 81-91
    • Calon, F.1    Morissette, M.2    Goulet, M.3    Grondin, R.4    Blanchet, P.J.5    Bedard, P.J.6    Di, P.T.7
  • 45
  • 46
    • 0034644473 scopus 로고    scopus 로고
    • Signaling to chromatin through histone modification
    • Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modification. Cell. 2000;103:263-271.
    • (2000) Cell , vol.103 , pp. 263-271
    • Cheung, P.1    Allis, C.D.2    Sassone-Corsi, P.3
  • 47
    • 61349185158 scopus 로고    scopus 로고
    • Role of the ERK/MSK1 signaling pathway in chromatin remodeling and brain responses to drugs of abuse
    • Brami-Cherrier K, Roze E, Girault JA, Betuing S, Caboche J. Role of the ERK/MSK1 signaling pathway in chromatin remodeling and brain responses to drugs of abuse. J Neurochem. 2009;108:1323-1335.
    • (2009) J Neurochem , vol.108 , pp. 1323-1335
    • Brami-Cherrier, K.1    Roze, E.2    Girault, J.A.3    Betuing, S.4    Caboche, J.5
  • 48
    • 40749086042 scopus 로고    scopus 로고
    • Parkinson's disease: Levodopa-induced dyskinesia and signal transduction
    • DOI 10.1111/j.1742-4658.2008.06296.x
    • Santini E, Valjent E, Fisone G. Parkinson's disease: levodopa-induced dyskinesia and signal transduction. FEBS J. 2008; 275:1392-1399. (Pubitemid 351388785)
    • (2008) FEBS Journal , vol.275 , Issue.7 , pp. 1392-1399
    • Santini, E.1    Valjent, E.2    Fisone, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.