Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods

Metabolic Brain Disease

Volumn 28, Issue 4, 2013, Pages 667-676

  Alimov, Alexander ^a   Wang, Haiping ^a   Liu, Mei ^b   Frank, Jacqueline A ^a   Xu, Mei ^a   Ou, Xiaoming ^c   Luo, Jia ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Alcohol; Brain development; Fetal alcohol syndrome; Gene expression; Neurodegeneration

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALCOHOL; ATAXIN 3; BECLIN 1; CASPASE 3; CATHEPSIN B; CATHEPSIN D; CATHEPSIN S; CCAAT ENHANCER BINDING PROTEIN BETA; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUCOSE REGULATED PROTEIN 78; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 9; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BNIP3;

ACTIVATING TRANSCRIPTION FACTOR 6 GENE; AMPLIFIED IN OSTEOSARCOMA GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIN 3 GENE; AUTOPHAGY; AUTOPHAGY RELATED 10; AUTOPHAGY RELATED 9A GENE; BECLIN 1 GENE; BNIP3 GENE; BRAIN DEVELOPMENT; BRAIN MATURATION; CATHEPSIN B GENE; CATHEPSIN D GENE; CATHEPSIN S GENE; CCAAT ENHANCER BINDING PROTEIN BETA GENE; CELL STRESS; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 2A GENE; ENDOPLASMIC RETICULUM CHAPERONE SIL 1 HOMOLOG GENE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 ALPHA KINASE 3 GENE; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1 GENE; GAMMA AMINOBUTYRIC ACID A RECEPTOR ASSOCIATED PROTEIN LIKE 1; GAMMA AMINOBUTYRIC ACID RECEPTOR ASSOCIATED ACID PROTEIN LIKE 2 GENE; GENE; GENE EXPRESSION; GENETIC REGULATION; GLUCOSE REGULATED PROTEIN 78 GENE; IMMUNONITY RELATED GTPASE FAMILY M MEMBER 1 GENE; IRE1 ALPHA GENE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1 GENE; MAMMALIAN TARGET OF RAPAMYCIN GENE; MICROARRAY ANALYSIS; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 ALPHA GENE; MITOGEN ACTIVATED PROTEIN KINASE 14 GENE; MITOGEN ACTIVATED PROTEIN KINASE 9 GENE; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NUCLEAR PROTEIN LOCALIZATION HOMOLOG GENE; NUCLEOTIDE SEQUENCE; PHOSPHATIDYLINOSITOL 3 4 5 TRISPHOSPHATE 3 PHOSPHATASE GENE; PHOSPHOINOSITIDE 3 KINASE 3 CATALYTIC GAMMA POLYPEPTIDE GENE; PHOSPHOINOSITIDE 3 KINASE CLASS 3 GENE; SEQUESTOSOME 1 GENE; SYNUCLEIN ALPHA GENE; THIRD TRIMESTER PREGNANCY; UNFOLDED PROTEIN RESPONSE; UNINDEXED SEQUENCE; WD REPEAT DOMAIN PHOSPHOINOSITIDE INTERACTING 1 GENE;

MUS;

ANIMALS; AUTOPHAGY; BRAIN; CASPASE 3; ETHANOL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, INBRED C57BL; NEURONS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84887226564     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-013-9430-2     Document Type: Article

References (34)

1. Chen G, Luo J (2010) Anthocyanins: are they beneficial in treating ethanol neurotoxicity? Neurotox Res 17(1):91-101
2. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J (2012) Autophagy is a protective response to ethanol neurotoxicity. Autophagy 8(11):1577-1589
3. Fernando P, Brunette S, Megeney LA (2005) Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J 19(12):1671-1673
4. Galluzzi L, Vicencio JM, Kepp O, Tasdemir E, Maiuri MC, Kroemer G (2008) To die or not to die: that is the autophagic question. Curr Mol Med 8(2):78-91
5. Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221(1):3-12
6. He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67-93
7. Hellemans KG, Sliwowska JH, Verma P, Weinberg J (2010) Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev 34(6):791-807
8. Ikonomidou C (2009) Triggers of apoptosis in the immature brain. Brain Dev 31(7):488-492
9. Ke Z, Wang X, Liu Y, Fan Z, Chen G, Xu M, Bower KA, Frank JA, Li M, Fang S, Shi X, Luo J (2011a) Ethanol induces endoplasmic reticulum stress in the developing brain. Alcohol Clin Exp Res 35(9):1574-1583
10. Ke Z, Liu Y, Wang X, Fan Z, Chen G, Xu M, Bower KA, Frank JA, Ou X, Shi X, Luo J (2011b) Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain. J Neurosci Res 89(10):1676-1684
11. Khan JY, Black SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr Res 54(1):77-82
12. Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132(1):27-42
13. Liu Y, Chen G, Ma C, Bower KA, Xu M, Fan Z, Shi X, Ke ZJ, Luo J (2009) Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity. J Neurosci Res 87(12):2793-2802
14. Luo J (2012) Mechanisms of ethanol-induced death of cerebellar granule cells. Cerebellum 11(1):145-154
15. Madalosso SH, Pérez-Villegas EM, Armengol JA (2005) Naturally occurring neuronal death during the postnatal development of Purkinje cells and their precerebellar afferent projections. Brain Res Brain Res Rev 49(2):267-279
16. Maier SE, Miller JA, Blackwell JM, West JR (1999) Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development. Alcohol Clin Exp Res 23(4):726-734
17. Mocchetti I, Bachis A, Masliah E (2008) Chemokine receptors and neurotrophic factors: potential therapy against aids dementia? J Neurosci Res 86(2):243-255
18. Olney JW, Tenkova T, Dikranian K, Muglia LJ, Jermakowicz WJ, D'Sa C, Roth KA (2002) Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 9(2):205-219
19. Oomman S, Finckbone V, Dertien J, Attridge J, Henne W, Medina M, Mansouri B, Singh H, Strahlendorf H, Strahlendorf J (2004) Active caspase-3 expression during postnatal development of rat cerebellum is not systematically or consistently associated with apoptosis. J Comp Neurol 476(2):154-173
20. Rasheva VI, Domingos PM (2009) Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis 14:996-1007
21. Riley EP, Infante MA, Warren KR (2011) Fetal alcohol spectrum disorders: an overview. Neuropsychol Rev 21(2):73-80
22. Ron D (2002) Translational control in the endoplasmic reticulum stress response. J Clin Invest 110:1383-1388
23. Shen HM, Codogno P (2011) Autophagic cell death: Loch Ness monster or endangered species? Autophagy 7(5):457-465
24. Shimoji M, Pagan F, Healton EB, Mocchetti I (2009) CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease. Neurotox Res 16(3):318-328
25. Siler-Marsiglio KI, Madorsky I, Pan Q, Paiva M, Neeley AW, Shaw G, Heaton MB (2006) Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Alcohol Clin Exp Res 30(6):1031-1038
26. Spreafico R, Frassoni C, Arcelli P, Selvaggio M, De Biasi S (1995) In situ labeling of apoptotic cell death in the cerebral cortex and thalamus of rats during development. J Comp Neurol 363(2):281-295
27. Tiveron MC, Boutin C, Daou P, Moepps B, Cremer H (2010) Expression and function of CXCR7 in the mouse forebrain. J Neuroimmunol 224(1-2):72-79
28. Vidal RL, Hetz C (2012) Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease. Autophagy 8(6):970-972
29. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ 17(3):488-498
30. Wang H, Bower KA, Frank JA, Xu M, Luo J (2013) Hypoxic preconditioning alleviates ethanol neurotoxicity: the involvement of autophagy. Neurotox Res
31. Wu Y, Peng H, Cui M, Whitney NP, Huang Y, Zheng JC (2009) CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway. J Neurochem 109(4):1157-1167
32. Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656-2664
33. Yakovlev A, Khafizova M, Abdullaev Z, Loukinov D, Kondratyev A (2010) Epigenetic regulation of caspase-3 gene expression in rat brain development. Gene 450(1-2):103-108
34. Zhu Y, Matsumoto T, Mikami S, Nagasawa T, Murakami F (2009) SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation. Development 136(11):1919-1928