Identification of sulfonic acids as efficient ecto-5′-nucleotidase inhibitors

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 685-691

  Iqbal, Jamshed ^a   Saeed, Aamer ^b   Raza, Rabia ^a   Matin, Abdul ^c   Hameed, Abdul ^d   Furtmann, Norbert ^e   Lecka, Joanna ^f,g   Sévigny, Jean ^f,g   Bajorath, Jürgen ^e  

^a Development Studies   (Pakistan)

^b QUAID I AZAM UNIVERSITY   (Pakistan)

^c Research and Development Center)   (Pakistan)

^d UNIVERSITY OF KARACHI   (Pakistan)

^e UNIVERSITY OF BONN   (Germany)

^f UNIVERSITÉ LAVAL   (Canada)

^g LAVAL UNIVERSITY   (Canada)

Author keywords

Adenosine; Binding mode; Cytotoxicity; Ecto 5 nucleotidase; Enzyme inhibition; Sulfonic acids

Indexed keywords

2 (4 AMINOPHENYL) 6 METHYLBENZO[D]THIAZOLE 7 SULFONIC ACID; 3 METHYL 1 PHENYL 1H PYRAZOL 5(4H) ONE; 4 (3 METHYL 5 OXO 4,5 DIHYDROPYRAZOL 1 YL)BENZENESULFONIC ACID; 4 AMINO 3 BROMO 9,10 DIOXO 9,10 DIHYDROANTHRACENE 1 SULFONIC ACID; 4 AMINO 3 HYDROXY 7 NITRONAPHTHALENE 1 SULFONIC ACID; 4 AMINO 5 HYDROXYNAPHTHALENE 2,7 DISULFONIC ACID; 4 HYDROXY 6 UREIDONAPHTHALENE 2 SULFONIC ACID; 5 AMINO 2 (4 NITROPHENYLAMINO)BENZENESULFONIC ACID; 6 AMINO 4 HYDROXYNAPHTHALENE 2 SULFONIC ACID; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; ECTO 5' NUCLEOTIDASE; ECTO 5' NUCLEOTIDASE INHIBITOR; ENZYME INHIBITOR; NAPHTHIONIC ACID; SODIUM 4 AMINONAPHTHALENE 1 SULFONIC ACID; SULFANILIC ACID; SULFONIC ACID DERIVATIVE; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CAPILLARY ELECTROPHORESIS; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LUNG CARCINOMA; STRUCTURE ACTIVITY RELATION;

ADENOSINE; BINDING MODE; CYTOTOXICITY; ECTO-5′-NUCLEOTIDASE; ENZYME INHIBITION; SULFONIC ACIDS;

5'-NUCLEOTIDASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; VINCRISTINE;

EID: 84887192967     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.053     Document Type: Article

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