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Volumn 73, Issue 21, 2013, Pages 6504-6515

MYC phosphorylation at novel regulatory regions suppresses transforming activity

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; MYC PROTEIN; ONCOPROTEIN;

EID: 84887183079     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4063     Document Type: Article
Times cited : (26)

References (40)
  • 1
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer 2008;8: 976-90.
    • (2008) Nat Rev Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 2
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011;146: 904-17.
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5    Jacobs, H.M.6
  • 3
    • 84876222028 scopus 로고    scopus 로고
    • Selective inhibition of tumor oncogenes by disruption of super-enhancers
    • Loven J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 2013;153: 320-34.
    • (2013) Cell , vol.153 , pp. 320-334
    • Loven, J.1    Hoke, H.A.2    Lin, C.Y.3    Lau, A.4    Orlando, D.A.5    Vakoc, C.R.6
  • 6
    • 33748138585 scopus 로고    scopus 로고
    • Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity, and biological function
    • Hann SR. Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity, and biological function. Semin Cancer Biol 2006;16: 288-302.
    • (2006) Semin Cancer Biol , vol.16 , pp. 288-302
    • Hann, S.R.1
  • 7
    • 79959450256 scopus 로고    scopus 로고
    • Proteolytic control of the oncoprotein transcription factor Myc
    • Thomas LR, Tansey WP. Proteolytic control of the oncoprotein transcription factor Myc. Adv Cancer Res 2011;110: 77-106.
    • (2011) Adv Cancer Res , vol.110 , pp. 77-106
    • Thomas, L.R.1    Tansey, W.P.2
  • 8
    • 13944252067 scopus 로고    scopus 로고
    • The life cycle of C-myc: From synthesis to degradation
    • Sears RC. The life cycle of C-myc: from synthesis to degradation. Cell Cycle 2004;3: 1133-7.
    • (2004) Cell Cycle , vol.3 , pp. 1133-1137
    • Sears, R.C.1
  • 9
    • 0034037132 scopus 로고    scopus 로고
    • The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals
    • Chang DW, Claassen GF, Hann SR, Cole MD. The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals. Mol Cell Biol 2000;20: 4309-19.
    • (2000) Mol Cell Biol , vol.20 , pp. 4309-4319
    • Chang, D.W.1    Claassen, G.F.2    Hann, S.R.3    Cole, M.D.4
  • 10
    • 0033861775 scopus 로고    scopus 로고
    • Induction of cell-cycle progression and acceleration of apoptosis are two separable functions of c-Myc: Transrepression correlates with acceleration of apoptosis
    • Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, et al. Induction of cell-cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol Cell Biol 2000;20: 6008-18.
    • (2000) Mol Cell Biol , vol.20 , pp. 6008-6018
    • Conzen, S.D.1    Gottlob, K.2    Kandel, E.S.3    Khanduri, P.4    Wagner, A.J.5    O'Leary, M.6
  • 12
    • 79551552058 scopus 로고    scopus 로고
    • Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland
    • Wang X, Cunningham M, Zhang X, Tokarz S, Laraway B, Troxell M, et al. Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland. Cancer Res 2011;71: 925-36.
    • (2011) Cancer Res , vol.71 , pp. 925-936
    • Wang, X.1    Cunningham, M.2    Zhang, X.3    Tokarz, S.4    Laraway, B.5    Troxell, M.6
  • 14
    • 84874778318 scopus 로고    scopus 로고
    • A mouse model with T58A mutations in Myc reduces the dependence on KRas mutations and has similarities to claudin-low human breast cancer
    • Hollern DP, Yuwanita I, Andrechek ER. A mouse model with T58A mutations in Myc reduces the dependence on KRas mutations and has similarities to claudin-low human breast cancer. Oncogene 2013;32: 1296-304.
    • (2013) Oncogene , vol.32 , pp. 1296-1304
    • Hollern, D.P.1    Yuwanita, I.2    Andrechek, E.R.3
  • 15
    • 0028023421 scopus 로고
    • Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis
    • Lutterbach B, Hann SR. Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol Cell Biol 1994;14: 5510-22.
    • (1994) Mol Cell Biol , vol.14 , pp. 5510-5522
    • Lutterbach, B.1    Hann, S.R.2
  • 16
    • 0030989077 scopus 로고    scopus 로고
    • Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation
    • Lutterbach B, Hann SR. Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation. Oncogene 1997;14: 967-75.
    • (1997) Oncogene , vol.14 , pp. 967-975
    • Lutterbach, B.1    Hann, S.R.2
  • 17
    • 0024446021 scopus 로고
    • Myc oncoproteins are phosphorylated by casein kinase II
    • Luscher B, Kuenzel EA, Krebs EG, Eisenman RN. Myc oncoproteins are phosphorylated by casein kinase II. EMBO J 1989;8: 1111-9.
    • (1989) EMBO J , vol.8 , pp. 1111-1119
    • Luscher, B.1    Kuenzel, E.A.2    Krebs, E.G.3    Eisenman, R.N.4
  • 18
    • 0032703216 scopus 로고    scopus 로고
    • Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
    • Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J Biol Chem 1999;274: 32580-7.
    • (1999) J Biol Chem , vol.274 , pp. 32580-32587
    • Noguchi, K.1    Kitanaka, C.2    Yamana, H.3    Kokubu, A.4    Mochizuki, T.5    Kuchino, Y.6
  • 19
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-68.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 20
  • 21
    • 58849102128 scopus 로고    scopus 로고
    • A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
    • Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A 2009;106: 480-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 480-485
    • Rahdar, M.1    Inoue, T.2    Meyer, T.3    Zhang, J.4    Vazquez, F.5    Devreotes, P.N.6
  • 22
    • 77649117952 scopus 로고    scopus 로고
    • Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data
    • Schweiger R, Linial M. Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data. Biol Direct 2010;5: 6.
    • (2010) Biol Direct , vol.5 , pp. 6
    • Schweiger, R.1    Linial, M.2
  • 23
    • 76749141997 scopus 로고    scopus 로고
    • Surface charge: A key determinant of protein localization and function
    • Goldenberg NM, Steinberg BE. Surface charge: a key determinant of protein localization and function. Cancer Res 2010;70: 1277-80.
    • (2010) Cancer Res , vol.70 , pp. 1277-1280
    • Goldenberg, N.M.1    Steinberg, B.E.2
  • 24
    • 65549147751 scopus 로고    scopus 로고
    • CDC25B mediates rapamycin-induced oncogenic responses in cancer cells
    • Chen RQ, Yang QK, Lu BW, Yi W, Cantin G, Chen YL, et al. CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 2009;69: 2663-8.
    • (2009) Cancer Res , vol.69 , pp. 2663-2668
    • Chen, R.Q.1    Yang, Q.K.2    Lu, B.W.3    Yi, W.4    Cantin, G.5    Chen, Y.L.6
  • 26
    • 0033081027 scopus 로고    scopus 로고
    • Destruction of Myc by ubiquitinmediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
    • Salghetti SE, Kim SY, Tansey WP. Destruction of Myc by ubiquitinmediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J 1999;18: 717-26.
    • (1999) EMBO J , vol.18 , pp. 717-726
    • Salghetti, S.E.1    Kim, S.Y.2    Tansey, W.P.3
  • 27
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000;14: 2501-14.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 28
    • 67649183547 scopus 로고    scopus 로고
    • Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant
    • Thibodeaux CA, Liu X, Disbrow GL, Zhang Y, Rone JD, Haddad BR, et al. Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant. Breast Cancer Res Treat 2009; 116: 281-94.
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 281-294
    • Thibodeaux, C.A.1    Liu, X.2    Disbrow, G.L.3    Zhang, Y.4    Rone, J.D.5    Haddad, B.R.6
  • 29
    • 0842347423 scopus 로고    scopus 로고
    • Negative control of the Myc protein by the stress-responsive kinase Pak2
    • Huang Z, Traugh JA, Bishop JM. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol 2004;24: 1582-94.
    • (2004) Mol Cell Biol , vol.24 , pp. 1582-1594
    • Huang, Z.1    Traugh, J.A.2    Bishop, J.M.3
  • 30
    • 79957897299 scopus 로고    scopus 로고
    • Epithelial cell organization suppresses Myc function by attenuating Myc expression
    • Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res 2011;71: 3822-30.
    • (2011) Cancer Res , vol.71 , pp. 3822-3830
    • Simpson, D.R.1    Yu, M.2    Zheng, S.3    Zhao, Z.4    Muthuswamy, S.K.5    Tansey, W.P.6
  • 35
    • 0021088187 scopus 로고
    • Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma
    • Rabbitts TH, Hamlyn PH, Baer R. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 1983;306: 760-5.
    • (1983) Nature , vol.306 , pp. 760-765
    • Rabbitts, T.H.1    Hamlyn, P.H.2    Baer, R.3
  • 36
    • 0027275755 scopus 로고
    • Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    • Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat Genet 1993; 5: 56-61.
    • (1993) Nat Genet , vol.5 , pp. 56-61
    • Bhatia, K.1    Huppi, K.2    Spangler, G.3    Siwarski, D.4    Iyer, R.5    Magrath, I.6
  • 37
    • 0028298840 scopus 로고
    • Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas
    • Bhatia K, Spangler G, Gaidano G, Hamdy N, Dalla-Favera R, Magrath I. Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas. Blood 1994;84: 883-8.
    • (1994) Blood , vol.84 , pp. 883-888
    • Bhatia, K.1    Spangler, G.2    Gaidano, G.3    Hamdy, N.4    Dalla-Favera, R.5    Magrath, I.6
  • 38
    • 33845919326 scopus 로고    scopus 로고
    • The ins and outs of MYC regulation by posttranslational mechanisms
    • Vervoorts J, Luscher-Firzlaff J, Luscher B. The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem 2006;281: 34725-9.
    • (2006) J Biol Chem , vol.281 , pp. 34725-34729
    • Vervoorts, J.1    Luscher-Firzlaff, J.2    Luscher, B.3
  • 40
    • 84894592163 scopus 로고    scopus 로고
    • MYC activity is negatively regulated by a C-terminal lysine cluster
    • Feb 25. [Epub ahead of print]
    • Wasylishen AR, Kalkat M, Kim SS, Pandyra A, Chan PK, Oliveri S, et al. MYC activity is negatively regulated by a C-terminal lysine cluster. Oncogene. 2013 Feb 25. [Epub ahead of print].
    • (2013) Oncogene
    • Wasylishen, A.R.1    Kalkat, M.2    Kim, S.S.3    Pandyra, A.4    Chan, P.K.5    Oliveri, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.