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Volumn 17, Issue 4, 2013, Pages 1094-1100

Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo

Author keywords

Antioxidant enzymes; Cyclooxygenase 2 (COX 2); Ginsenoside Rd; Inducible nitric oxide synthase (iNOS); Mitogen activated protein kinases (MAPKs); Nuclear factor B (NF B)

Indexed keywords

CATALASE; CYCLOOXYGENASE 2; DEXAMETHASONE; ENZYME; GINSENOSIDE RD; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; NITRIC OXIDE; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE;

EID: 84887166458     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.10.013     Document Type: Article
Times cited : (53)

References (43)
  • 1
    • 77953639975 scopus 로고    scopus 로고
    • Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice
    • G.J. Huang, S.S. Huang, S.S. Lin, Y.Y. Shao, C.C. Chen, and W.C. Hou Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice J Agric Food Chem 58 2010 7445 7452
    • (2010) J Agric Food Chem , vol.58 , pp. 7445-7452
    • Huang, G.J.1    Huang, S.S.2    Lin, S.S.3    Shao, Y.Y.4    Chen, C.C.5    Hou, W.C.6
  • 2
    • 79952537526 scopus 로고    scopus 로고
    • Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonicaex vivo and in vivo
    • C.T. Chang, S.S. Huang, S.S. Lin, S. Amagaya, H.Y. Ho, and W.C. Hou Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonicaex vivo and in vivo Food Chem 127 2011 1131 1137
    • (2011) Food Chem , vol.127 , pp. 1131-1137
    • Chang, C.T.1    Huang, S.S.2    Lin, S.S.3    Amagaya, S.4    Ho, H.Y.5    Hou, W.C.6
  • 4
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem Biol Interact 160 2006 1 40
    • (2006) Chem Biol Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 6
    • 78651383851 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo
    • M.H. Huang, S.S. Huang, B.S. Wang, C.H. Wu, M.J. Sheu, and W.C. Hou Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo J Ethnopharmacol 133 2011 743 750
    • (2011) J Ethnopharmacol , vol.133 , pp. 743-750
    • Huang, M.H.1    Huang, S.S.2    Wang, B.S.3    Wu, C.H.4    Sheu, M.J.5    Hou, W.C.6
  • 7
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • A.S. Attele, J.A. Wu, and C.S. Yuan Ginseng pharmacology: multiple constituents and multiple actions Biochem Pharmacol 58 1999 1685 1693
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 8
    • 4444239425 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease
    • W. Zhou, H. Chai, P.H. Lin, A.B. Lumsden, Q. Yao, and C.J. Chen Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease Med Sci Monit 10 2004 187 192
    • (2004) Med Sci Monit , vol.10 , pp. 187-192
    • Zhou, W.1    Chai, H.2    Lin, P.H.3    Lumsden, A.B.4    Yao, Q.5    Chen, C.J.6
  • 9
    • 13444293396 scopus 로고    scopus 로고
    • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
    • Y. Cheng, L.H. Shen, and J.T. Zhang Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action Acta Pharmacol Sin 26 2005 143 149
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 143-149
    • Cheng, Y.1    Shen, L.H.2    Zhang, J.T.3
  • 10
    • 71049183577 scopus 로고    scopus 로고
    • Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
    • H. Liu, J. Yang, F. Du, X. Gao, X. Ma, and Y. Huang Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats Drug Metab Dispos 37 2009 2290 2298
    • (2009) Drug Metab Dispos , vol.37 , pp. 2290-2298
    • Liu, H.1    Yang, J.2    Du, F.3    Gao, X.4    Ma, X.5    Huang, Y.6
  • 12
    • 67249094291 scopus 로고
    • Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs
    • C.A. Winter, E.A. Risley, and G.W. Nuss Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs Proc Soc Exp Biol Med 111 1962 544 547
    • (1962) Proc Soc Exp Biol Med , vol.111 , pp. 544-547
    • Winter, C.A.1    Risley, E.A.2    Nuss, G.W.3
  • 13
    • 0021742157 scopus 로고
    • Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models
    • J.E. Krawisz, P. Sharon, and W.F. Stenson Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models Gastroenterology 87 1984 1344 1350
    • (1984) Gastroenterology , vol.87 , pp. 1344-1350
    • Krawisz, J.E.1    Sharon, P.2    Stenson, W.F.3
  • 14
    • 0021923228 scopus 로고
    • A new assay method for lipid peroxides using a methylene blue derivative
    • N. Ohishi, H. Ohkawa, A. Miike, T. Tatano, and K. Yagi A new assay method for lipid peroxides using a methylene blue derivative Biochem Int 10 1985 205 211
    • (1985) Biochem Int , vol.10 , pp. 205-211
    • Ohishi, N.1    Ohkawa, H.2    Miike, A.3    Tatano, T.4    Yagi, K.5
  • 16
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signaling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
    • B. Kaminska MAPK signaling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits Biochim Biophys Acta 1754 2005 253 262
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 17
    • 79952412498 scopus 로고    scopus 로고
    • Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling
    • C.H. Hsing, M.C. Lin, P.C. Choi, W.C. Huang, J.I. Kai, and C.C. Tsai Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling PLoS One 6 2011 e17598
    • (2011) PLoS One , vol.6 , pp. 17598
    • Hsing, C.H.1    Lin, M.C.2    Choi, P.C.3    Huang, W.C.4    Kai, J.I.5    Tsai, C.C.6
  • 18
    • 78649891437 scopus 로고    scopus 로고
    • In vitro and in vivo anti-inflammatory activity of 17-O-acetylacuminolide through the inhibition of cytokines. NF-κB translocation and IKKβ activity
    • M. Achoui, D. Appleton, M.A. Abdulla, K. Awang, M.A. Mohd, and M.R. Mustafa In vitro and in vivo anti-inflammatory activity of 17-O- acetylacuminolide through the inhibition of cytokines. NF-κB translocation and IKKβ activity PLoS One 5 2010 e15105
    • (2010) PLoS One , vol.5 , pp. 15105
    • Achoui, M.1    Appleton, D.2    Abdulla, M.A.3    Awang, K.4    Mohd, M.A.5    Mustafa, M.R.6
  • 19
    • 0024368804 scopus 로고
    • Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: Rat pleurisy induced by carrageenin and phorbol myristate acetate
    • S. Oh-ishi, I. Hayashi, M. Hayashi, K. Yamaki, and I. Utsunomiya Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate Dermatologica 179 1989 68 71
    • (1989) Dermatologica , vol.179 , pp. 68-71
    • Oh-Ishi, S.1    Hayashi, I.2    Hayashi, M.3    Yamaki, K.4    Utsunomiya, I.5
  • 20
    • 0026335390 scopus 로고
    • A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse
    • J. Dawson, A.D. Sedgwick, J.C. Edwards, and P. Lees A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse Int J Tissue React 13 1991 171 185
    • (1991) Int J Tissue React , vol.13 , pp. 171-185
    • Dawson, J.1    Sedgwick, A.D.2    Edwards, J.C.3    Lees, P.4
  • 21
    • 0025914077 scopus 로고
    • Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenan-induced inflammation: Effect of non-steroidal anti-inflammatory drugs
    • B.M. Peskar, M. Trautmann, P. Nowak, and B.A. Peskar Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenan-induced inflammation: effect of non-steroidal anti-inflammatory drugs Agents Actions 33 1991 240 246
    • (1991) Agents Actions , vol.33 , pp. 240-246
    • Peskar, B.M.1    Trautmann, M.2    Nowak, P.3    Peskar, B.A.4
  • 22
    • 0031226491 scopus 로고    scopus 로고
    • Protective effect of melatonin in carrageenin-induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity
    • S. Cuzzocrea, B. Zingarelli, E. Gilard, P. Hake, A.L. Salzman, and C. Szabó Protective effect of melatonin in carrageenin-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity J Pineal Res 23 1997 106 116
    • (1997) J Pineal Res , vol.23 , pp. 106-116
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilard, E.3    Hake, P.4    Salzman, A.L.5    Szabó, C.6
  • 23
    • 0015832229 scopus 로고
    • Differentiation of human monocytes in bone marrow and blood. Sequential formation of two granule populations
    • B.A. Nichols, and D.F. Bainton Differentiation of human monocytes in bone marrow and blood. Sequential formation of two granule populations Lab Invest 29 1973 27 40
    • (1973) Lab Invest , vol.29 , pp. 27-40
    • Nichols, B.A.1    Bainton, D.F.2
  • 25
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: Friend and foe
    • S.J. Klebanoff Myeloperoxidase: friend and foe J Leukoc Biol 77 2005 598-625
    • (2005) J Leukoc Biol , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 26
    • 0018144790 scopus 로고
    • Characterization and quantification of the peroxidase in human monocytes
    • A. Bos, R. Wever, and D. Roos Characterization and quantification of the peroxidase in human monocytes Biochim Biophys Acta 525 1978 37 44
    • (1978) Biochim Biophys Acta , vol.525 , pp. 37-44
    • Bos, A.1    Wever, R.2    Roos, D.3
  • 28
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: Friend and foe
    • S.J. Klebanoff Myeloperoxidase: friend and foe J Leukoc Biol 77 2005 598-25
    • (2005) J Leukoc Biol , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 29
    • 80054879532 scopus 로고    scopus 로고
    • Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola
    • J.S. Deng, C.S. Chi, S.S. Huang, P.H. Shie, T.H. Lin, and G.J. Huang Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola J Ethnopharmacol 137 2011 1161 1171
    • (2011) J Ethnopharmacol , vol.137 , pp. 1161-1171
    • Deng, J.S.1    Chi, C.S.2    Huang, S.S.3    Shie, P.H.4    Lin, T.H.5    Huang, G.J.6
  • 30
    • 0028151406 scopus 로고
    • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation
    • H. Rubbo, R. Radi, M. Trujillo, R. Telleri, B. Kalyanaraman, and S. Barnes Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation J Biol Chem 269 1994 26066 26075
    • (1994) J Biol Chem , vol.269 , pp. 26066-26075
    • Rubbo, H.1    Radi, R.2    Trujillo, M.3    Telleri, R.4    Kalyanaraman, B.5    Barnes, S.6
  • 31
    • 84863013934 scopus 로고    scopus 로고
    • Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide- stimulated macrophages and the λ-carrageenan-induced paw edema model
    • G.J. Huang, C.H. Pan, and C.H. Wu Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model J Nat Prod 75 2012 54 59
    • (2012) J Nat Prod , vol.75 , pp. 54-59
    • Huang, G.J.1    Pan, C.H.2    Wu, C.H.3
  • 32
    • 0026629902 scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • C. Nanthan Nitric oxide as a secretory product of mammalian cells FASEB J 6 1992 3051 3064
    • (1992) FASEB J , vol.6 , pp. 3051-3064
    • Nanthan, C.1
  • 33
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • J.K. Kundu, and Y.J. Surh Inflammation: gearing the journey to cancer Mutat Res 659 2008 15 30
    • (2008) Mutat Res , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 34
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-κB activity Annu Rev Immunol 18 2000 621 663
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 35
    • 33846260180 scopus 로고    scopus 로고
    • Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappa B/MAP kinases in lipopolysaccharide-treated RAW 264.7cells
    • M.S. Choi, S.H. Lee, H.S. Cho, Y. Kim, Y.P. Yun, and H.Y. Jung Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappa B/MAP kinases in lipopolysaccharide-treated RAW 264.7cells Eur J Pharmacol 556 2007 181 189
    • (2007) Eur J Pharmacol , vol.556 , pp. 181-189
    • Choi, M.S.1    Lee, S.H.2    Cho, H.S.3    Kim, Y.4    Yun, Y.P.5    Jung, H.Y.6
  • 36
    • 56949083956 scopus 로고    scopus 로고
    • Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappa B signaling pathways
    • H.J. Choi, J.S. Eun, Y.R. Park, D.K. Kim, R. Li, and W.S. Moon Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide- stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappa B signaling pathways Eur J Pharmacol 601 2008 171 178
    • (2008) Eur J Pharmacol , vol.601 , pp. 171-178
    • Choi, H.J.1    Eun, J.S.2    Park, Y.R.3    Kim, D.K.4    Li, R.5    Moon, W.S.6
  • 37
    • 0037247748 scopus 로고    scopus 로고
    • Nuclear factor-kappa B as a therapeutic target in critical care medicine
    • B. Zingarelli, M. Sheehan, and H.R. Wong Nuclear factor-kappa B as a therapeutic target in critical care medicine Crit Care Med 31 2003 S105 S111
    • (2003) Crit Care Med , vol.31
    • Zingarelli, B.1    Sheehan, M.2    Wong, H.R.3
  • 38
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 39
    • 44649175701 scopus 로고    scopus 로고
    • Carrageenan-induced NF kappa B activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10
    • S. Bhattacharyya, P.K. Dudeja, and J.K. Tobacman Carrageenan-induced NF kappa B activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10 Biochim Biophys Acta 1780 2008 973 982
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 973-982
    • Bhattacharyya, S.1    Dudeja, P.K.2    Tobacman, J.K.3
  • 40
    • 33644820971 scopus 로고    scopus 로고
    • Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappa B and p38 MAP kinase activity in LPS-stimulated RAW264.7 cells
    • J.H. Kim, D.H. Kim, S.H. Baek, H.J. Lee, M.R. Kim, and H.J. Kwon Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappa B and p38 MAP kinase activity in LPS-stimulated RAW264.7 cells Biochem Pharmacol 71 2006 1198 1205
    • (2006) Biochem Pharmacol , vol.71 , pp. 1198-1205
    • Kim, J.H.1    Kim, D.H.2    Baek, S.H.3    Lee, H.J.4    Kim, M.R.5    Kwon, H.J.6
  • 41
    • 33644961589 scopus 로고    scopus 로고
    • The naturally occurring bioflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappa B regulation, in RAW264.7 cells
    • S.J. Suh, T.W. Chung, M.J. Son, S.H. Kim, T.C. Moon, and K.H. Son The naturally occurring bioflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappa B regulation, in RAW264.7 cells Arch Biochem Biophys 447 2006 136 146
    • (2006) Arch Biochem Biophys , vol.447 , pp. 136-146
    • Suh, S.J.1    Chung, T.W.2    Son, M.J.3    Kim, S.H.4    Moon, T.C.5    Son, K.H.6
  • 42
    • 0032925361 scopus 로고    scopus 로고
    • Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma
    • S.J. Ajizian, B.K. English, and E.A. Meals Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma J Infect Dis 179 1999 939 944
    • (1999) J Infect Dis , vol.179 , pp. 939-944
    • Ajizian, S.J.1    English, B.K.2    Meals, E.A.3
  • 43
    • 0032951716 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
    • J.L. Dean, M. Brook, A.R. Clark, and J. Saklatvala p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes J Biol Chem 274 1999 264 269
    • (1999) J Biol Chem , vol.274 , pp. 264-269
    • Dean, J.L.1    Brook, M.2    Clark, A.R.3    Saklatvala, J.4


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