메뉴 건너뛰기




Volumn 3, Issue 1, 2009, Pages 16-20

Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion

Author keywords

Biphasic secretion; Bursting; Derivative control; Granules; Oscillations

Indexed keywords

INSULIN;

EID: 84887153619     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229680900300103     Document Type: Article
Times cited : (32)

References (68)
  • 1
    • 20044389102 scopus 로고    scopus 로고
    • Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release
    • Ravier MA, Güldenagel M, Charollais A, Gjinovci A, Caille D, Söhl G, Wollheim CB, Willecke K, Henquin JC, Meda P. Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes. 2005;54(6):1798-807.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1798-1807
    • Ravier, M.A.1    Güldenagel, M.2    Charollais, A.3    Gjinovci, A.4    Caille, D.5    Söhl, G.6    Wollheim, C.B.7    Willecke, K.8    Henquin, J.C.9    Meda, P.10
  • 2
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 2000;49(11):1751-60.
    • (2000) Diabetes , vol.49 , Issue.11 , pp. 1751-1760
    • Henquin, J.C.1
  • 3
    • 0011648510 scopus 로고    scopus 로고
    • The in vivo regulation of pulsatile insulin secretion
    • Pørksen N. The in vivo regulation of pulsatile insulin secretion. Diabetologia. 2002;45(1):3-20.
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 3-20
    • Pørksen, N.1
  • 4
    • 35148816130 scopus 로고    scopus 로고
    • Metabolic and electrical oscillations: Partners in controlling pulsatile insulin secretion
    • Bertram R, Sherman A, Satin LS. Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab. 2007;293(4):E890-900.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.4
    • Bertram, R.1    Sherman, A.2    Satin, L.S.3
  • 5
    • 0020957719 scopus 로고
    • Minimal model for membrane oscillations in the pancreatic beta-cell
    • Chay TR, Keizer J. Minimal model for membrane oscillations in the pancreatic beta-cell. Biophys J. 1983;42(2):181-90.
    • (1983) Biophys J , vol.42 , Issue.2 , pp. 181-190
    • Chay, T.R.1    Keizer, J.2
  • 6
    • 0019249588 scopus 로고
    • The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell
    • Atwater I, Dawson CM, Scott A, Eddlestone G, Rojas E. The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell. Horm Metab Res Suppl. 1980;Suppl 10:100-7.
    • (1980) Horm Metab Res Suppl , Issue.SUPPL. 10 , pp. 100-107
    • Atwater, I.1    Dawson, C.M.2    Scott, A.3    Eddlestone, G.4    Rojas, E.5
  • 7
    • 0000117122 scopus 로고
    • Bursting oscillations in an excitable membrane model
    • Sleeman BD, Jarvis RJ, eds. Ordinary and partial differential equations, New York: Springer
    • Rinzel J. Bursting oscillations in an excitable membrane model. In: Sleeman BD, Jarvis RJ, eds. Ordinary and partial differential equations, lecture notes in mathematics, 1151. New York: Springer; 1985. pp. 304-16.
    • (1985) Lecture Notes in Mathematics , vol.1151 , pp. 304-316
    • Rinzel, J.1
  • 8
    • 0024791707 scopus 로고
    • Glucose-induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans
    • Valdeolmillos M, Santos RM, Contreras D, Soria B, Rosario LM. Glucose-induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans. FEBS Lett. 1989;259(1):19-23.
    • (1989) FEBS Lett , vol.259 , Issue.1 , pp. 19-23
    • Valdeolmillos, M.1    Santos, R.M.2    Contreras, D.3    Soria, B.4    Rosario, L.M.5
  • 9
    • 0344339740 scopus 로고    scopus 로고
    • Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells
    • Göpel SO, Kanno T, Barg S, Eliasson L, Galvanovskis J, Renström E, Rorsman P. Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells. J Gen Physiol. 1999;114(6):759-70.
    • (1999) J Gen Physiol , vol.114 , Issue.6 , pp. 759-770
    • Göpel, S.O.1    Kanno, T.2    Barg, S.3    Eliasson, L.4    Galvanovskis, J.5    Renström, E.6    Rorsman, P.7
  • 10
    • 0036712559 scopus 로고    scopus 로고
    • Calcium-activated K+ channels of mouse beta-cells are controlled by both store and cytoplasmic Ca2+: Experimental and theoretical studies
    • Goforth PB, Bertram R, Khan FA, Zhang M, Sherman A, Satin LS. Calcium-activated K+ channels of mouse beta-cells are controlled by both store and cytoplasmic Ca2+: experimental and theoretical studies. J Gen Physiol. 2002;120(3):307-22.
    • (2002) J Gen Physiol , vol.120 , Issue.3 , pp. 307-322
    • Goforth, P.B.1    Bertram, R.2    Khan, F.A.3    Zhang, M.4    Sherman, A.5    Satin, L.S.6
  • 11
    • 35348964085 scopus 로고    scopus 로고
    • The electrophysiology of the beta-cell based on single transmembrane protein characteristics
    • Meyer-Hermann ME. The electrophysiology of the beta-cell based on single transmembrane protein characteristics. Biophys J. 2007;93(8):2952-68.
    • (2007) Biophys J , vol.93 , Issue.8 , pp. 2952-2968
    • Meyer-Hermann, M.E.1
  • 12
    • 0029784059 scopus 로고    scopus 로고
    • Contributions of modeling to understanding stimulus-secretion coupling in pancreatic beta-cells
    • Sherman A. Contributions of modeling to understanding stimulus-secretion coupling in pancreatic beta-cells. Am J Physiol. 1996;271(2 Pt 1):E362-72.
    • (1996) Am J Physiol , vol.271 , Issue.2 PART 1
    • Sherman, A.1
  • 13
    • 84967387125 scopus 로고    scopus 로고
    • Negative calcium feedback: The road from Chay-Keizer
    • Coombes S, Bressloff PC, eds. Singapore: World Scientific
    • Bertram R, Sherman A. Negative calcium feedback: the road from Chay-Keizer. In: Coombes S, Bressloff PC, eds. Bursting: the genesis of rhythm in the nervous system. Singapore: World Scientific; 2005. pp. 19-48.
    • (2005) Bursting: The Genesis of Rhythm in the Nervous System , pp. 19-48
    • Bertram, R.1    Sherman, A.2
  • 14
    • 0030278163 scopus 로고    scopus 로고
    • Electrical bursting and luminal calcium oscillation in excitable cell models
    • Chay TR. Electrical bursting and luminal calcium oscillation in excitable cell models. Biol Cybern. 1996;75(5):419-31.
    • (1996) Biol Cybern , vol.75 , Issue.5 , pp. 419-431
    • Chay, T.R.1
  • 15
    • 0030808053 scopus 로고    scopus 로고
    • Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells
    • Chay TR. Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells. Biophys J. 1997;73(3):1673-88.
    • (1997) Biophys J , vol.73 , Issue.3 , pp. 1673-1688
    • Chay, T.R.1
  • 18
    • 0024323358 scopus 로고
    • ATP-sensitive potassium channel and bursting in the pancreatic beta cell. A theoretical study
    • Keizer J, Magnus G. ATP-sensitive potassium channel and bursting in the pancreatic beta cell. A theoretical study. Biophys J. 1989;56(2):229-42.
    • (1989) Biophys J , vol.56 , Issue.2 , pp. 229-242
    • Keizer, J.1    Magnus, G.2
  • 19
    • 3042708493 scopus 로고    scopus 로고
    • A calcium-based phantom bursting model for pancreatic islets
    • Bertram R, Sherman A. A calcium-based phantom bursting model for pancreatic islets. Bull Math Biol. 2004;66(5):1313-44.
    • (2004) Bull Math Biol , vol.66 , Issue.5 , pp. 1313-1344
    • Bertram, R.1    Sherman, A.2
  • 20
    • 0037663837 scopus 로고    scopus 로고
    • Modeling of Ca2+ flux in pancreatic beta-cells: Role of the plasma membrane and intracellular stores
    • Fridlyand LE, Tamarina N, Philipson LH. Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores. Am J Physiol Endocrinol Metab. 2003;285(1):E138-54.
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , Issue.1
    • Fridlyand, L.E.1    Tamarina, N.2    Philipson, L.H.3
  • 21
    • 0033058934 scopus 로고    scopus 로고
    • Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances
    • Kinard TA, de Vries G, Sherman A, Satin LS. Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances. Biophys J. 1999;76(3):1423-35.
    • (1999) Biophys J , vol.76 , Issue.3 , pp. 1423-1435
    • Kinard, T.A.1    De Vries, G.2    Sherman, A.3    Satin, L.S.4
  • 22
    • 10044256230 scopus 로고    scopus 로고
    • Calcium and glycolysis mediate multiple bursting modes in pancreatic islets
    • Bertram R, Satin L, Zhang M, Smolen P, Sherman A. Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J. 2004;87(5):3074-87.
    • (2004) Biophys J , vol.87 , Issue.5 , pp. 3074-3087
    • Bertram, R.1    Satin, L.2    Zhang, M.3    Smolen, P.4    Sherman, A.5
  • 23
    • 34247603072 scopus 로고    scopus 로고
    • Rhythm of the β-cell oscillator is not governed by a single regulator: Multiple systems contribute to oscillatory behavior
    • Heart E, Smith PJS. Rhythm of the β-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior. Am J Physiol Endocrinol Metab. 2007;292(5):E1295-300.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.5
    • Heart, E.1    Smith, P.J.S.2
  • 24
    • 0025054950 scopus 로고
    • Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells
    • Smith PA, Ashcroft FM, Rorsman P. Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells. FEBS Lett. 1990;261(1):187-90.
    • (1990) FEBS Lett , vol.261 , Issue.1 , pp. 187-190
    • Smith, P.A.1    Ashcroft, F.M.2    Rorsman, P.3
  • 25
    • 34548017201 scopus 로고    scopus 로고
    • Phantom bursting is highly sensitive to noise and unlikely to account for slow bursting in beta-cells: Considerations in favor of metabolically driven oscillations
    • Pedersen MG. Phantom bursting is highly sensitive to noise and unlikely to account for slow bursting in beta-cells: considerations in favor of metabolically driven oscillations. J Theor Biol. 2007;248(2):391-400.
    • (2007) J Theor Biol , vol.248 , Issue.2 , pp. 391-400
    • Pedersen, M.G.1
  • 26
    • 0021019170 scopus 로고
    • Properties of the Ca-activated K+ channel in pancreatic beta-cells
    • Atwater I, Rosario L, Rojas E. Properties of the Ca-activated K+ channel in pancreatic beta-cells. Cell Calcium. 1983;4(5-6):451-61.
    • (1983) Cell Calcium , vol.4 , Issue.5-6 , pp. 451-461
    • Atwater, I.1    Rosario, L.2    Rojas, E.3
  • 27
    • 0023751870 scopus 로고
    • Role of single-channel stochastic noise on bursting clusters of pancreatic beta-cells
    • Chay TR, Kang HS. Role of single-channel stochastic noise on bursting clusters of pancreatic beta-cells. Biophys J. 1988;54(3):427-35.
    • (1988) Biophys J , vol.54 , Issue.3 , pp. 427-435
    • Chay, T.R.1    Kang, H.S.2
  • 28
    • 0023791327 scopus 로고
    • Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing
    • Sherman A, Rinzel J, Keizer J. Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing. Biophys J. 1988;54(3):411-25.
    • (1988) Biophys J , vol.54 , Issue.3 , pp. 411-425
    • Sherman, A.1    Rinzel, J.2    Keizer, J.3
  • 29
    • 34247628855 scopus 로고    scopus 로고
    • The effect of noise on β-cell burst period
    • Pedersen MG, Sørensen MP. The effect of noise on β-cell burst period. SIAM J Appl Math. 2007;67:530-42.
    • (2007) SIAM J Appl Math , vol.67 , pp. 530-542
    • Pedersen, M.G.1    Sørensen, M.P.2
  • 30
    • 0027161335 scopus 로고
    • Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis
    • Smolen P, Rinzel J, Sherman A. Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis. Biophys J. 1993;64(6):1668-80.
    • (1993) Biophys J , vol.64 , Issue.6 , pp. 1668-1680
    • Smolen, P.1    Rinzel, J.2    Sherman, A.3
  • 31
    • 3042736858 scopus 로고    scopus 로고
    • Three roads to islet bursting: Emergent oscillations in coupled phantom bursters
    • Zimliki CL, Mears D, Sherman A. Three roads to islet bursting: emergent oscillations in coupled phantom bursters. Biophys J. 2004;87(1):193-206.
    • (2004) Biophys J , vol.87 , Issue.1 , pp. 193-206
    • Zimliki, C.L.1    Mears, D.2    Sherman, A.3
  • 32
    • 34047149839 scopus 로고    scopus 로고
    • Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics
    • Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M. Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes. 2007;56(4):1078-86.
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1078-1086
    • Speier, S.1    Gjinovci, A.2    Charollais, A.3    Meda, P.4    Rupnik, M.5
  • 33
    • 0025827061 scopus 로고
    • Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets
    • Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991;266(14):9314-9.
    • (1991) J Biol Chem , vol.266 , Issue.14 , pp. 9314-9319
    • Longo, E.A.1    Tornheim, K.2    Deeney, J.T.3    Varnum, B.A.4    Tillotson, D.5    Prentki, M.6    Corkey, B.E.7
  • 34
    • 0030756468 scopus 로고    scopus 로고
    • Are metabolic oscillations responsible for normal oscillatory insulin secretion?
    • Tornheim K. Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes. 1997;46(9):1375-80.
    • (1997) Diabetes , vol.46 , Issue.9 , pp. 1375-1380
    • Tornheim, K.1
  • 35
    • 33645525256 scopus 로고    scopus 로고
    • Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets
    • Luciani DS, Misler S, Polonsky KS. Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets. J Physiol. 2006;572(Pt 2):379-92.
    • (2006) J Physiol , vol.572 , Issue.PART 2 , pp. 379-392
    • Luciani, D.S.1    Misler, S.2    Polonsky, K.S.3
  • 36
    • 0036314357 scopus 로고    scopus 로고
    • Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet beta-cells: Evidence for a Ca2+-dependent mechanism
    • Ainscow EK, Rutter GA. Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet beta-cells: evidence for a Ca2+-dependent mechanism. Diabetes. 2002;51 Suppl 1:S162-70.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Ainscow, E.K.1    Rutter, G.A.2
  • 37
    • 0034011770 scopus 로고    scopus 로고
    • Correlated oscillations in glucose consumption, oxygen consumption, and intracellular free Ca(2+) in single islets of Langerhans
    • Jung SK, Kauri LM, Qian WJ, Kennedy RT. Correlated oscillations in glucose consumption, oxygen consumption, and intracellular free Ca(2+) in single islets of Langerhans. J Biol Chem. 2000;275(9):6642-50.
    • (2000) J Biol Chem , vol.275 , Issue.9 , pp. 6642-6650
    • Jung, S.K.1    Kauri, L.M.2    Qian, W.J.3    Kennedy, R.T.4
  • 38
    • 44949172767 scopus 로고    scopus 로고
    • ATP, mitochondrial calcium and mitochondrial pH responses during nutrient activation of the pancreatic cell
    • Wiederkehr A, Park K-S, Dupont O, Demaurex N, Pozzan T, Wollheim CB. ATP, mitochondrial calcium and mitochondrial pH responses during nutrient activation of the pancreatic cell . Diabetologia. 2007;50 Suppl 1:S74-5.
    • (2007) Diabetologia , vol.50 , Issue.SUPPL. 1
    • Wiederkehr, A.1    Park, K.-S.2    Dupont, O.3    Demaurex, N.4    Pozzan, T.5    Wollheim, C.B.6
  • 40
    • 0030840117 scopus 로고    scopus 로고
    • Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentrations of effectors
    • MacDonald MJ, Al-Masri H, Jumelle-Laclau M, Cruz MO. Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentrations of effectors. Diabetes. 1997;46(12):1996-2001.
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 1996-2001
    • MacDonald, M.J.1    Al-Masri, H.2    Jumelle-Laclau, M.3    Cruz, M.O.4
  • 41
    • 33847772664 scopus 로고    scopus 로고
    • Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets
    • Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A. Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys J. 2007;92(5):1544-55.
    • (2007) Biophys J , vol.92 , Issue.5 , pp. 1544-1555
    • Bertram, R.1    Satin, L.S.2    Pedersen, M.G.3    Luciani, D.S.4    Sherman, A.5
  • 42
    • 2642542358 scopus 로고    scopus 로고
    • Complex bursting in pancreatic islets: A potential glycolytic mechanism
    • Wierschem K, Bertram R. Complex bursting in pancreatic islets: a potential glycolytic mechanism. J Theor Biol. 2004;228(4):513-21.
    • (2004) J Theor Biol , vol.228 , Issue.4 , pp. 513-521
    • Wierschem, K.1    Bertram, R.2
  • 43
    • 33644874708 scopus 로고    scopus 로고
    • Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
    • Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006;290(1):E143-8.
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.1
    • Heart, E.1    Corkey, R.F.2    Wikstrom, J.D.3    Shirihai, O.S.4    Corkey, B.E.5
  • 45
    • 0030767184 scopus 로고    scopus 로고
    • Minimal model of beta-cell mitochondrial Ca2+ handling
    • Magnus G, Keizer J. Minimal model of beta-cell mitochondrial Ca2+ handling. Am J Physiol. 1997;273(2 Pt 1):C717-33.
    • (1997) Am J Physiol , vol.273 , Issue.2 PART 1
    • Magnus, G.1    Keizer, J.2
  • 46
    • 37149054439 scopus 로고    scopus 로고
    • Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: A computational approach
    • Fridlyand LE, Harbeck MC, Roe MW, Philipson LH. Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach. Am J Physiol Cell Physiol. 2007;293(6):C1924-33.
    • (2007) Am J Physiol Cell Physiol , vol.293 , Issue.6
    • Fridlyand, L.E.1    Harbeck, M.C.2    Roe, M.W.3    Philipson, L.H.4
  • 47
    • 0030792753 scopus 로고    scopus 로고
    • Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells
    • Renström E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol. 1997;502(Pt 1):105-18.
    • (1997) J Physiol , vol.502 , Issue.PART 1 , pp. 105-118
    • Renström, E.1    Eliasson, L.2    Rorsman, P.3
  • 49
    • 0015381760 scopus 로고
    • A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling
    • Grodsky GM. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest. 1972;51(8):2047-59.
    • (1972) J Clin Invest , vol.51 , Issue.8 , pp. 2047-2059
    • Grodsky, G.M.1
  • 50
    • 0019013375 scopus 로고
    • Comparison of storage- and signal-limited models of pancreatic insulin secretion
    • O'Connor MD, Landahl H, Grodsky GM. Comparison of storage- and signal-limited models of pancreatic insulin secretion. Am J Physiol. 1980;238(5):R378-89.
    • (1980) Am J Physiol , vol.238 , Issue.5
    • O'Connor, M.D.1    Landahl, H.2    Grodsky, G.M.3
  • 51
    • 0016230485 scopus 로고
    • A mathematical model for the glucose induced insulin release in man
    • Cerasi E, Fick G, Rudemo M. A mathematical model for the glucose induced insulin release in man. Eur J Clin Invest. 1974;4(4):267-78.
    • (1974) Eur J Clin Invest , vol.4 , Issue.4 , pp. 267-278
    • Cerasi, E.1    Fick, G.2    Rudemo, M.3
  • 52
    • 0036314212 scopus 로고    scopus 로고
    • Modeling phasic insulin release: Immediate and time-dependent effects of glucose
    • Nesher R, Cerasi E. Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes. 2002;51 Suppl 1:S53-9.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Nesher, R.1    Cerasi, E.2
  • 53
    • 0014336473 scopus 로고
    • Dynamics of insulin secretion by the perfused rat pancreas
    • Curry DL, Bennett LL, Grodsky GM. Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology. 1968;83(3):572-84.
    • (1968) Endocrinology , vol.83 , Issue.3 , pp. 572-584
    • Curry, D.L.1    Bennett, L.L.2    Grodsky, G.M.3
  • 54
    • 0032832621 scopus 로고    scopus 로고
    • Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion
    • Daniel S, Noda M, Straub SG, Sharp GW. Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion. Diabetes. 1999;48(9):1686-90.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1686-1690
    • Daniel, S.1    Noda, M.2    Straub, S.G.3    Sharp, G.W.4
  • 57
    • 0034745951 scopus 로고    scopus 로고
    • Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response
    • Jonkers FC, Henquin JC. Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response. Diabetes. 2001;50(3):540-50.
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 540-550
    • Jonkers, F.C.1    Henquin, J.C.2
  • 59
    • 0020289635 scopus 로고
    • Comparison of models of insulin release
    • Landahl HD, Grodsky GM. Comparison of models of insulin release. Bull Math Biol. 1982;44(3):399-409.
    • (1982) Bull Math Biol , vol.44 , Issue.3 , pp. 399-409
    • Landahl, H.D.1    Grodsky, G.M.2
  • 61
    • 0015808117 scopus 로고
    • Threshold secretory mechanism: A model of derivative element in biological control
    • Licko V. Threshold secretory mechanism: a model of derivative element in biological control. Bull Math Biol. 1973;35(1):51-8.
    • (1973) Bull Math Biol , vol.35 , Issue.1 , pp. 51-58
    • Licko, V.1
  • 62
    • 34547138896 scopus 로고    scopus 로고
    • Insulin granule trafficking in beta-cells: Mathematical model of glucose-induced insulin secretion
    • Bertuzzi A, Salinari S, Mingrone G. Insulin granule trafficking in beta-cells: mathematical model of glucose-induced insulin secretion. Am J Physiol Endocrinol Metab. 2007;293(1):E396-409.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.1
    • Bertuzzi, A.1    Salinari, S.2    Mingrone, G.3
  • 63
    • 51649087725 scopus 로고    scopus 로고
    • Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis
    • Chen YD, Wang S, Sherman A. Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis. Biophys J. 2008;95(5):2226-41.
    • (2008) Biophys J , vol.95 , Issue.5 , pp. 2226-2241
    • Chen, Y.D.1    Wang, S.2    Sherman, A.3
  • 64
    • 10344258585 scopus 로고    scopus 로고
    • Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+
    • Wan QF, Dong Y, Yang H, Lou X, Ding J, Xu T. Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+. J Gen Physiol. 2004;124(6):653-62.
    • (2004) J Gen Physiol , vol.124 , Issue.6 , pp. 653-662
    • Wan, Q.F.1    Dong, Y.2    Yang, H.3    Lou, X.4    Ding, J.5    Xu, T.6
  • 65
    • 10344221040 scopus 로고    scopus 로고
    • A highly Ca 2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells
    • Yang Y, Gillis KD. A highly Ca 2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells. J Gen Physiol. 2004;124(6):641-51.
    • (2004) J Gen Physiol , vol.124 , Issue.6 , pp. 641-651
    • Yang, Y.1    Gillis, K.D.2
  • 67
    • 48249083049 scopus 로고    scopus 로고
    • Voltage-gated ion channels in human pancreatic beta-cells: Electrophysiological characterization and role in insulin secretion
    • Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes. 2008;57(6):1618-28.
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1618-1628
    • Braun, M.1    Ramracheya, R.2    Bengtsson, M.3    Zhang, Q.4    Karanauskaite, J.5    Partridge, C.6    Johnson, P.R.7    Rorsman, P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.