EMT-MET in renal disease: Should we curb our enthusiasm?

Cancer Letters

Volumn 341, Issue 1, 2013, Pages 24-29

  Galichon, Pierre ^a,b,c   Finianos, Serge ^b   Hertig, Alexandre ^a,b,c  

^a INSERM   (France)

^b HÔPITAL TENON   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Epithelial to mesenchymal transition; Fibrosis; Kidney; Tubular epithelial cell

Indexed keywords

CALCINEURIN INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OSTEOGENIC PROTEIN 1;

CELL DIFFERENTIATION; CORRELATION ANALYSIS; DISEASE MARKER; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FIBROBLAST; HUMAN; KIDNEY DISEASE; KIDNEY EPITHELIUM; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MESENCHYMAL EPITHELIAL TRANSITION; NEOPLASM; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY;

EID: 84887130500     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.04.018     Document Type: Review

References (47)

1. Hay E.D. An overview of epithelio-mesenchymal transformation. Acta Anat. (Basel) 1995, 154(1):8-20.
2. Hay E.D., Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am. J. Kidney Dis. 1995, 26(4):678-690.
3. Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 7(2):131-142.
4. Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J. Clin. Invest. 2011, 121(2):468-474.
5. Zeisberg M., Duffield J.S. Resolved: EMT produces fibroblasts in the kidney. J. Am. Soc. Nephrol. 2010, 21(8):1247-1253.
6. Neilson E.G. Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia. J. Am. Soc. Nephrol. 2007, 18(7):1995-1998.
7. Strutz F., Okada H., Lo C.W., Danoff T., Carone R.L., Tomaszewski J.E., et al. Identification and characterization of a fibroblast marker: FSP1. J. Cell Biol. 1995, 130(2):393-405.
8. Vongwiwatana A., Tasanarong A., Rayner D.C., Melk A., Halloran P.F. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am. J. Transplant. 2005, 5(6):1367-1374.
9. Rastaldi M.P., Ferrario F., Giardino L., Dell'Antonio G., Grillo C., Grillo P., et al. Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int. 2002, 62(1):137-146.
10. Hertig A., Verine J., Mougenot B., Jouanneau C., Ouali N., Sebe P., et al. Risk factors for early epithelial to mesenchymal transition in renal grafts. Am. J. Transplant. 2006, 6(12):2937-2946.
11. Hertig A., Anglicheau D., Verine J., Pallet N., Touzot M., Ancel P.-Y., et al. Early epithelial phenotypic changes predict graft fibrosis. J. Am. Soc. Nephrol. 2008, 19(8):1584-1591.
12. Xu-Dubois Y.-C., Baugey E., Peltier J., Colombat M., Ouali N., Jouanneau C., et al. Epithelial phenotypic changes are associated with a tubular active fibrogenic process in human renal grafts. Hum. Pathol. 2013, 17(1).
13. Hazzan M., Hertig A., Buob D., Copin M.-C., Noël C., Rondeau E., et al. Epithelial-to-mesenchymal transition predicts cyclosporine nephrotoxicity in renal transplant recipients. J. Am. Soc. Nephrol. 2011, 22(7):1375-1381.
14. Humphreys B.D., Lin S.-L., Kobayashi A., Hudson T.E., Nowlin B.T., Bonventre J.V., et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am. J. Pathol. 2010, 176(January):85-97.
15. Faulkner J.L., Szcykalski L.M., Springer F., Barnes J.L. Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am. J. Pathol. 2005, 167(5):1193-1205.
16. Koesters R., Kaissling B., Lehir M., Picard N., Theilig F., Gebhardt R., et al. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am. J. Pathol. 2010, 177(2):632-643.
17. Mengel M., Sis B., Haas M., Colvin R.B., Halloran P.F., Racusen L.C., et al. Banff 2011 meeting report: new concepts in antibody-mediated rejection. Am. J. Transplant. 2012, 12(3):563-570.
18. Galichon P., Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?. Fibrogen. Tissue Repair. 2011, 4:11.
19. Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119(6):1420-1428.
20. Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 2002, 110(3):341-350.
21. Österreicher C.H., Penz-Österreicher M., Grivennikov S.I., Guma M., Koltsova E.K., Datz C., et al. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc. Natl. Acad. Sci. USA 2011, 108(1):308-313.
22. Zeisberg M., Hanai J., Sugimoto H., Mammoto T., Charytan D., Strutz F., et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 2003, 9(7):964-968.
23. Zeisberg M., Shah A.A., Kalluri R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J. Biol. Chem. 2005, 280(9):8094-8100.
24. Lin S.-L., Kisseleva T., Brenner D.A., Duffield J.S. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am. J. Pathol. 2008, 173(6):1617-1627.
25. Rowe R.G., Lin Y., Shimizu-Hirota R., Hanada S., Neilson E.G., Greenson J.K., et al. Hepatocyte-derived Snail1 propagates liver fibrosis progression. Mol. Cell. Biol. 2011, 31(12):2392-2403.
26. Sugimoto H., LeBleu V.S., Bosukonda D., Keck P., Taduri G., Bechtel W., et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat. Med. 2012, 18(3):396-404.
27. Paldi A. What makes the cell differentiate?. Prog. Biophys. Mol. Biol. 2012, 110(1):41-43.
28. Theise N.D., Nimmakayalu M., Gardner R., Illei P.B., Morgan G., Teperman L., et al. Liver from bone marrow in humans. Hepatology 2000, 32(1):11-16.
29. Poulsom R., Forbes S.J., Hodivala-Dilke K., Ryan E., Wyles S., Navaratnarasah S., et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J. Pathol. 2001, 195(2):229-235.
30. Gupta S., Verfaillie C., Chmielewski D., Kim Y., Rosenberg M.E. A role for extrarenal cells in the regeneration following acute renal failure. Kidney Int. 2002, 62(4):1285-1290.
31. Lin F., Moran A., Igarashi P. Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. J. Clin. Invest. 2005, 115(7):1756-1764.
32. Duffield J.S., Park K.M., Hsiao L.-L., Kelley V.R., Scadden D.T., Ichimura T., et al. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J. Clin. Invest. 2005, 115(7):1743-1755.
33. Humphreys B.D., Valerius M.T., Kobayashi A., Mugford J.W., Soeung S., Duffield J.S., et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008, 2(3):284-291.
34. Humphreys B.D., Czerniak S., DiRocco D.P., Hasnain W., Cheema R., Bonventre J.V. Repair of injured proximal tubule does not involve specialized progenitors. Proc. Natl. Acad. Sci. USA 2011, 108(22):9226-9231.
35. Mani S.A., Guo W., Liao M.-J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008, 133(4):704-715.
36. Jinde K., Nikolic-Paterson D.J., Huang X.R., Sakai H., Kurokawa K., Atkins R.C., et al. Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis. Am. J. Kidney Dis. 2001, 38(4):761-769.
37. Giannico G., Yang H., Neilson E.G., Fogo A.B. Dystroglycan in the diagnosis of FSGS. Clin. J. Am. Soc. Nephrol. 2009, 4(11):1747-1753.
38. Bariety J., Hill G.S., Mandet C., Irinopoulou T., Jacquot C., Meyrier A., et al. Glomerular epithelial-mesenchymal transdifferentiation in pauci-immune crescentic glomerulonephritis. Nephrol. Dial. Transplant. 2003, 18(9):1777-1784.
39. de Matos A.C.C., Câmara N.O.S., Tonato E.J., Durão Júnior M.de S., Franco M.F., Moura L.A.R., et al. Vimentin expression and myofibroblast infiltration are early markers of renal dysfunction in kidney transplantation: an early stage of chronic allograft dysfunction?. Transplant. Proc. 2010, 42(9):3482-3488.
40. Hertig A., Bonnard G., Ulinski T., Colombat M., Jouanneau C., Baugey E., et al. Tubular nuclear accumulation of Snail and epithelial phenotypic changes in human myeloma cast nephropathy. Hum. Pathol. 2011, 42(8):1142-1148.
41. Thiery J.P., Acloque H., Huang R.Y.J., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139(5):871-890.
42. Vitalone M.J., O'Connell P.J., Jimenez-Vera E., Yuksel A., Wavamunno M., Fung C.L.-S., et al. Epithelial-to-mesenchymal transition in early transplant tubulointerstitial damage. J. Am. Soc. Nephrol. 2008, 19(8):1571-1583.
43. Zhou Y., Mao H., Li S., Cao S., Li Z., Zhuang S., et al. HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J. Am. Soc. Nephrol. 2010, 21(4):598-609.
44. Yang J., Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J. Am. Soc. Nephrol. 2002, 13(1):96-107.
45. Tan X., Li Y., Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J. Am. Soc. Nephrol. 2006, 17(12):3382-3393.
46. Surendran K., Schiavi S., Hruska K.A. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J. Am. Soc. Nephrol. 2005, 16(8):2373-2384.
47. Li Y., Tan X., Dai C., Stolz D.B., Wang D., Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J. Am. Soc. Nephrol. 2009, 20(9):1907-1918.