Programmed Cell Death in Rheumatoid Arthritis Peripheral Blood T-Cell Subpopulations Determined by Laser Scanning Cytometry

Laboratory Investigation

Volumn 83, Issue 12, 2003, Pages 1839-1848

  Szodoray, Peter ^a,c   Jellestad, Stig ^a   Nakken, Britt ^b   Brun, Johan G ^a   Jonsson, Roland ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CD4 ANTIGEN; CD8 ANTIGEN; CD95 ANTIBODY; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DIGOXIGENIN; FAS ANTIGEN; FAS LIGAND; INFLIXIMAB; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOMETRY; DISEASE ACTIVITY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LASER SCANNING CYTOMETRY; LIGAND BINDING; LYMPHOCYTE CULTURE; LYMPHOCYTE SUBPOPULATION; MALE; MOLECULAR CLONING; MONONUCLEAR CELL; NICK END LABELING; NUCLEAR CONDENSATION ANALYSIS; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; STAINING; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTIGENS, CD95; APOPTOSIS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FAS LIGAND PROTEIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMAGE CYTOMETRY; IN SITU NICK-END LABELING; LASERS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0347364747     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000101703.80133.99     Document Type: Article

References (30)

1. Adams JM and Cory S (1998). The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326.
2. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, and Hunder GG (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324.
3. Bijl M, Horst G, Limburg PC, and Kallenberg CG (2001). Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus (SLE): Relation to lymphocyte activation and disease activity. Lupus 10:866-872.
4. Cantwell MJ, Hua T, Zvaifler NJ, and Kipps TJ (1997). Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum 40: 1644-1652.
5. Choy EH, Kingsley GH, and Panayi GS (1998). Monoclonal antibody therapy in rheumatoid arthritis. Br J Rheumatol 37:484-490.
6. Cope AP (2002). Studies of T-cell activation in chronic inflammation. Arthritis Res 4(Suppl 3):S197-S211.
7. Emlen W, Niebur J, and Kadera R (1994). Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 152:3685-3692.
8. Funauchi M, Sugiyama M, SukYoo B, Ikoma S, Ohno M, Kinoshita K, and Kanamaru A (2001). A possible role of apoptosis for regulating autoreactive responses in systemic lupus erythematosus. Lupus 10:284-288.
9. Hale LP and Haynes BF (2001). Pathology of rheumatoid arthritis and associated disorders, 14th ed. In: Koopman WJ, editor. Arthritis and allied conditions: A textbook of rheumatology. Philadelphia: Lippincott Williams & Wilkins, 1103-1127.
10. Hashimoto H, Tanaka M, Suda T, Tomita T, Hayashida K, Takeuchi E, Kaneko M, Takano H, Nagata S, and Ochi T (1998). Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 41: 657-662.
11. Kusenda J (1998). Bcl-2 family proteins and leukemia: Mini-review. Neoplasma 45:117-122.
12. Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, and Kalden JR (1997). In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 40:306-317.
13. + T cells in rheumatoid arthritis. Histol Histopathol 15:587-591.
14. Nordstrom DC (1989). DNA synthesis in CD4- and CD8-positive cells in synovial fluid of patients with reactive and rheumatoid arthritis. Rheumatol Int 8:269-272.
15. Ohlsson M, Szodoray P, Loro LL, Johannessen AC, and Jonsson R (2002). CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: A putative anti-apoptotic role during its effector phases. Scand J Immunol 56:561-571.
16. Oltvai ZN, Milliman CL, and Korsmeyer SJ (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
17. Pap T, Gay RE, and Gay S (2002). Rheumatoid arthritis, 2nd ed. In: Theofilopoulos AN and Bona CA, editors. The molecular pathology of autoimmune diseases. New York: Taylor & Francis, 376-401.
18. Papo T, Parizot C, Ortova M, Piette JC, Frances C, Debre P, Godeau P, and Gorochov G (1998). Apoptosis and expression of soluble Fas mRNA in systemic lupus erythematosus. Lupus 7:455-461.
19. Pope RM (2002). Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2:527-535.
20. Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, and van Riel PL (1995). Modified disease activity scores that include twenty-eight-joint counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44-48.
21. Schulze-Koops H and Lipsky PE (2000). Anti-CD4 monoclonal antibody therapy in human autoimmune diseases. Curr Dir Autoimmun 2:24-49.
22. + T lymphocytes on the basis of CDR3 diversity. Int Immunol 6:897-907.
23. Stummvoll GH, Aringer M, Smolen JS, Koller M, Kiener HP, Steiner CW, Bohle B, Knobler R, and Graninger WB (2000). Derangement of apoptosis related lymphocyte homeostasis in systemic sclerosis. Rheumatology 39:1341-1350.
24. Szekanecz Z, Strieter RM, Kunkel SL, and Koch AE (1998). Chemokines in rheumatoid arthritis. Springer Semin Immunopathol 20:115-132.
25. Talmadge JE, Singh R, Ageitos A, and Buyukberber S (2001). Potential for cytokine and product manipulation to improve the results of autologous stem cell transplantation for rheumatoid arthritis. J Rheumatol Suppl 64:32-38.
26. Vollertsen RS and Conn DL (1990). Vasculitis associated with rheumatoid arthritis. Rheum Dis Clin North Am 16:445-461.
27. Wagner UG, Koetz K, Wey CM, and Goronzy JJ (1998). Perturbation of the T cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci USA 95:14447-14452.
28. Wedderburn LR, Robinson N, Patel A, Varsani H, and Woo P (2000). Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis. Arthritis Rheum 43:765-774.
29. Zeher M, Szodoray P, Gyimesi E, and Szondy Z (1999). Correlation of increased susceptibility to apoptosis of CD4+ T cells with lymphocyte activation and activity of disease in patients with primary Sjögren's syndrome. Arthritis Rheum 42:1673-1681.
30. Ziff M (1989). Pathways of mononuclear cell infiltration in rheumatoid synovitis. Rheumatol Int 9:97-103.