OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis

Biochemical Pharmacology

Volumn 86, Issue 10, 2013, Pages 1430-1440

  Bai, Li Yuan ^a,b   Weng, Jing Ru ^c   Chiu, Chang Fang ^a,b   Wu, Chia Yung ^c   Yeh, Su Peng ^a,b   Sargeant, Aaron M ^d   Lin, Po Han ^a   Liao, Yu Min ^a  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

Acute myeloid leukemia; Glutathione; Indole 3 carbinol; OSU A9; Reactive oxygen species

Indexed keywords

3 INDOLEMETHANOL; [1 (4 CHLORO 3 NITROBENZENE SULFONYL) 1H INDOL 3 YL]METHANOL; ACETYLCYSTEINE; ANTILEUKEMIC AGENT; AZACITIDINE; CYCLIN A; CYCLIN B1; CYTARABINE; ETOPOSIDE; GLUTATHIONE; HYDROXYUREA; OSUA 9; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BODY WEIGHT; BONE MARROW CELL; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; WEIGHT REDUCTION; WESTERN BLOTTING;

ACUTE MYELOID LEUKEMIA; GLUTATHIONE; INDOLE-3-CARBINOL; OSU-A9; REACTIVE OXYGEN SPECIES;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; CYCLIN A; CYCLIN B1; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; INDOLES; LEUKEMIA, MYELOID, ACUTE; METHANOL; MICE; MICE, NUDE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84887064161     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.09.002     Document Type: Article

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