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Volumn 110, Issue 44, 2013, Pages 17969-17974

ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63

Author keywords

[No Author keywords available]

Indexed keywords

CARISOPRODOL; I KAPPA B; PROTEIN ASPP2; PROTEIN P63; SYNAPTOTAGMIN I; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84887055453     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309362110     Document Type: Article
Times cited : (43)

References (39)
  • 1
    • 0022527161 scopus 로고
    • Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
    • Quintanilla M, Brown K, Ramsden M, Balmain A (1986) Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322(6074):78-80.
    • (1986) Nature , vol.322 , Issue.6074 , pp. 78-80
    • Quintanilla, M.1    Brown, K.2    Ramsden, M.3    Balmain, A.4
  • 2
    • 10844223748 scopus 로고    scopus 로고
    • Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis
    • Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind JS (2004) Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res 64(24):8804-8807.
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 8804-8807
    • Vitale-Cross, L.1    Amornphimoltham, P.2    Fisher, G.3    Molinolo, A.A.4    Gutkind, J.S.5
  • 3
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp CJ, Donehower LA, Bradley A, Balmain A (1993) Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74(5):813-822.
    • (1993) Cell , vol.74 , Issue.5 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 4
    • 38849167565 scopus 로고    scopus 로고
    • Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors
    • Martínez-Cruz AB, et al. (2008) Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res 68(3):683-692.
    • (2008) Cancer Res , vol.68 , Issue.3 , pp. 683-692
    • Martínez-Cruz, A.B.1
  • 5
    • 30544444184 scopus 로고    scopus 로고
    • Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
    • Qiao W, et al. (2006) Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene 25(2):207-217.
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 207-217
    • Qiao, W.1
  • 6
    • 0032477945 scopus 로고    scopus 로고
    • Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB
    • Seitz CS, Lin Q, Deng H, Khavari PA (1998) Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB. Proc Natl Acad Sci USA 95(5):2307-2312.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.5 , pp. 2307-2312
    • Seitz, C.S.1    Lin, Q.2    Deng, H.3    Khavari, P.A.4
  • 7
    • 0033565763 scopus 로고    scopus 로고
    • Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling
    • van Hogerlinden M, Rozell BL, Ahrlund-Richter L, Toftgard R (1999) Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling. Cancer Res 59(14):3299-3303.
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3299-3303
    • Van Hogerlinden, M.1    Rozell, B.L.2    Ahrlund-Richter, L.3    Toftgard, R.4
  • 8
    • 0037421484 scopus 로고    scopus 로고
    • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
    • Dajee M, et al. (2003) NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421(6923):639-643.
    • (2003) Nature , vol.421 , Issue.6923 , pp. 639-643
    • Dajee, M.1
  • 9
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for i kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    • Liu B, et al. (2006) A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci USA 103(46): 17202-17207.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.46 , pp. 17202-17207
    • Liu, B.1
  • 11
    • 33645894992 scopus 로고    scopus 로고
    • Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
    • Nguyen BC, et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 20(8):1028-1042.
    • (2006) Genes Dev , vol.20 , Issue.8 , pp. 1028-1042
    • Nguyen, B.C.1
  • 12
    • 0033594491 scopus 로고    scopus 로고
    • P63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills AA, et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398(6729):708-713.
    • (1999) Nature , vol.398 , Issue.6729 , pp. 708-713
    • Mills, A.A.1
  • 13
    • 0033594485 scopus 로고    scopus 로고
    • P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • Yang A, et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398(6729):714-718.
    • (1999) Nature , vol.398 , Issue.6729 , pp. 714-718
    • Yang, A.1
  • 14
    • 0036187907 scopus 로고    scopus 로고
    • P63 expression profiles in human normal and tumor tissues
    • Di Como CJ, et al. (2002) p63 expression profiles in human normal and tumor tissues. Clin Cancer Res 8(2):494-501.
    • (2002) Clin Cancer Res , vol.8 , Issue.2 , pp. 494-501
    • Di Como, C.J.1
  • 15
    • 33847230852 scopus 로고    scopus 로고
    • The p53 family in differentiation and tumorigenesis
    • Stiewe T (2007) The p53 family in differentiation and tumorigenesis. Nat Rev Cancer 7(3):165-168.
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 165-168
    • Stiewe, T.1
  • 16
    • 67649159970 scopus 로고    scopus 로고
    • TAp63 prevents premature aging by promoting adult stem cell maintenance
    • Su X, et al. (2009) TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 64-75
    • Su, X.1
  • 17
    • 33847023954 scopus 로고    scopus 로고
    • TAp63 and DeltaNp63 in cancer and epidermal development
    • Candi E, et al. (2007) TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle 6(3):274-285.
    • (2007) Cell Cycle , vol.6 , Issue.3 , pp. 274-285
    • Candi, E.1
  • 18
    • 38449101897 scopus 로고    scopus 로고
    • Mechanisms regulating epithelial stratification
    • Koster MI, Roop DR (2007) Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol 23:93-113.
    • (2007) Annu Rev Cell Dev Biol , vol.23 , pp. 93-113
    • Koster, M.I.1    Roop, D.R.2
  • 19
    • 79551607574 scopus 로고    scopus 로고
    • Np63 is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    • Keyes WM, et al. (2011) Np63 is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 8(2):164-176.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 164-176
    • Keyes, W.M.1
  • 20
    • 10044266819 scopus 로고    scopus 로고
    • Dominant negative p63 isoform expression in head and neck squamous cell carcinoma
    • Sniezek JC, Matheny KE, Westfall MD, Pietenpol JA (2004) Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. Laryngoscope 114(12): 2063-2072.
    • (2004) Laryngoscope , vol.114 , Issue.12 , pp. 2063-2072
    • Sniezek, J.C.1    Matheny, K.E.2    Westfall, M.D.3    Pietenpol, J.A.4
  • 21
    • 17944379798 scopus 로고    scopus 로고
    • ASPP proteins specifically stimulate the apoptotic function of p53
    • Samuels-Lev Y, et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8(4):781-794.
    • (2001) Mol Cell , vol.8 , Issue.4 , pp. 781-794
    • Samuels-Lev, Y.1
  • 22
    • 1642499353 scopus 로고    scopus 로고
    • ASPP1 and ASPP2: Common activators of p53 family members
    • Bergamaschi D, et al. (2004) ASPP1 and ASPP2: Common activators of p53 family members. Mol Cell Biol 24(3):1341-1350.
    • (2004) Mol Cell Biol , vol.24 , Issue.3 , pp. 1341-1350
    • Bergamaschi, D.1
  • 23
    • 0037312920 scopus 로고    scopus 로고
    • IASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
    • Bergamaschi D, et al. (2003) iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 33(2):162-167.
    • (2003) Nat Genet , vol.33 , Issue.2 , pp. 162-167
    • Bergamaschi, D.1
  • 24
    • 33646578801 scopus 로고    scopus 로고
    • ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
    • Vives V, et al. (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20(10):1262-1267.
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1262-1267
    • Vives, V.1
  • 25
    • 63149117341 scopus 로고    scopus 로고
    • Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
    • Kampa KM, et al. (2009) Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci USA 106(11):4390-4395.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.11 , pp. 4390-4395
    • Kampa, K.M.1
  • 26
    • 78651312057 scopus 로고    scopus 로고
    • SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence
    • Wang XD, et al. (2011) SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence. Cell Death Differ 18(2):304-314.
    • (2011) Cell Death Differ , vol.18 , Issue.2 , pp. 304-314
    • Wang, X.D.1
  • 27
    • 84865191462 scopus 로고    scopus 로고
    • Autophagic activity dictates the cellular response to oncogenic RAS
    • Wang Y, et al. (2012) Autophagic activity dictates the cellular response to oncogenic RAS. Proc Natl Acad Sci USA 109(33):13325-13330.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.33 , pp. 13325-13330
    • Wang, Y.1
  • 28
    • 80053619221 scopus 로고    scopus 로고
    • Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
    • Notari M, et al. (2011) Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci USA 108(40):16645-16650.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.40 , pp. 16645-16650
    • Notari, M.1
  • 29
    • 80054938836 scopus 로고    scopus 로고
    • IASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
    • Chikh A, et al. (2011) iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J 30(20):4261-4273.
    • (2011) EMBO J , vol.30 , Issue.20 , pp. 4261-4273
    • Chikh, A.1
  • 30
    • 84877826693 scopus 로고    scopus 로고
    • Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
    • Lu M, et al. (2013) Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell 23(5):618-633.
    • (2013) Cancer Cell , vol.23 , Issue.5 , pp. 618-633
    • Lu, M.1
  • 31
    • 0033636739 scopus 로고    scopus 로고
    • Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome
    • Kuperwasser C, et al. (2000) Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. Am J Pathol 157(6): 2151-2159.
    • (2000) Am J Pathol , vol.157 , Issue.6 , pp. 2151-2159
    • Kuperwasser, C.1
  • 32
    • 77954905229 scopus 로고    scopus 로고
    • ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development
    • Sottocornola R, et al. (2010) ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell 19(1):126-137.
    • (2010) Dev Cell , vol.19 , Issue.1 , pp. 126-137
    • Sottocornola, R.1
  • 33
    • 0028596185 scopus 로고
    • Sunburn and p53 in the onset of skin cancer
    • Ziegler A, et al. (1994) Sunburn and p53 in the onset of skin cancer. Nature 372(6508): 773-776.
    • (1994) Nature , vol.372 , Issue.6508 , pp. 773-776
    • Ziegler, A.1
  • 34
    • 81255168184 scopus 로고    scopus 로고
    • TP63 P2 promoter functional analysis identifies α-catenin as a key regulator of Np63 expression
    • Ruptier C, et al. (2011) TP63 P2 promoter functional analysis identifies α-catenin as a key regulator of Np63 expression. Oncogene 30(46):4656-4665.
    • (2011) Oncogene , vol.30 , Issue.46 , pp. 4656-4665
    • Ruptier, C.1
  • 35
    • 33947166199 scopus 로고    scopus 로고
    • Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases
    • Lefort K, et al. (2007) Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev 21(5):562-577.
    • (2007) Genes Dev , vol.21 , Issue.5 , pp. 562-577
    • Lefort, K.1
  • 36
    • 0033575818 scopus 로고    scopus 로고
    • NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
    • Yang JP, et al. (1999) NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene 18(37):5177-5186.
    • (1999) Oncogene , vol.18 , Issue.37 , pp. 5177-5186
    • Yang, J.P.1
  • 37
    • 84874949078 scopus 로고    scopus 로고
    • ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
    • Wang Y, et al. (2013) ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells. Cell Death Differ 20(4):525-534.
    • (2013) Cell Death Differ , vol.20 , Issue.4 , pp. 525-534
    • Wang, Y.1
  • 38
    • 54249090199 scopus 로고    scopus 로고
    • BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds
    • Pal-Ghosh S, Tadvalkar G, Jurjus RA, Zieske JD, Stepp MA (2008) BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Exp Eye Res 87(5):478-486.
    • (2008) Exp Eye Res , vol.87 , Issue.5 , pp. 478-486
    • Pal-Ghosh, S.1    Tadvalkar, G.2    Jurjus, R.A.3    Zieske, J.D.4    Stepp, M.A.5
  • 39
    • 0033571118 scopus 로고    scopus 로고
    • Vivo gene expression profile analysis of human breast cancer progression
    • Sgroi DC, et al. (1999) In vivo gene expression profile analysis of human breast cancer progression. Cancer Res 59(22):5656-5661.
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5656-5661
    • Sgroi, D.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.