The antidepressants fluoxetine and bupropion differentially affect proceptive behavior in the naturally cycling female rat

Journal of Sexual Medicine

Volumn 10, Issue 11, 2013, Pages 2679-2687

  Ventura Aquino, Elisa ^a   Fernández Guasti, Alonso ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Antidepressants; Bupropion; Female; Fluoxetine; Proceptivity; Receptivity; Sexual Motivation; Yohimbine

Indexed keywords

AMFEBUTAMONE; FLUOXETINE; YOHIMBINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EAR; EJACULATION; ESTRUS CYCLE; FEMALE; LOCOMOTION; LORDOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROESTRUS; RAT; SEXUAL BEHAVIOR; SINGLE DRUG DOSE;

ANTIDEPRESSANTS; BUPROPION; FEMALE; FLUOXETINE; PROCEPTIVITY; RECEPTIVITY; SEXUAL MOTIVATION; YOHIMBINE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BUPROPION; ESTROUS CYCLE; FEMALE; FLUOXETINE; HUMANS; MALE; RATS; SEROTONIN UPTAKE INHIBITORS; SEX FACTORS; SEXUAL BEHAVIOR, ANIMAL; YOHIMBINE;

EID: 84887053749     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12280     Document Type: Article

References (55)

1. Beach FA. Sexual attractivity, proceptivity, and receptivity in female mammals. Horm Behav 1976;7:105-138.
2. Blaustein JD, Erskine MS. Feminine sexual behavior: Cellular integration of hormonal and afferent information in the rodent forebrain. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, brain and behavior. New York: Academic Press; 2002:139-214.
3. Blaustein JD. Feminine reproductive behavior and physiology in rodents: Integration of hormonal, behavioral and environmental influences. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, brain and behavior. San Diego: Elsevier; 2009:67-107.
4. Erskine MS. Solicitation behavior in the estrous female rat: A review. Horm Behav 1989;23:473-502.
5. Ågmo A. Sexual motivation-An inquiry into events determining the occurrence of sexual behavior. Behav Brain Res 1999;105:129-150.
6. Madlafousek J, Hliňák Z, Beran J. Decline of sexual behavior in castrated male rats: Effects of female precopulatory behavior. Horm Behav 1976;7:245-252.
7. Fadem BH, Barfield RJ, Whalen RE. Dose-response and time-response relationships between progesterone and the display of patterns of receptive and proceptive behavior in the female rat. Horm Behav 1979;13:40-48.
8. Rössler AS, Pfaus JG, Kia HK, Bernabé J, Alexandre L, Giuliano F. The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacol Biochem Behav 2006;85:514-521.
9. Fernández-Guasti A, Vega-Matuszczyk J, Larsson K. Synergistic action of estradiol, progesterone and testosterone on rat proceptive behavior. Physiol Behav 1991;50:1007-1011.
10. Higgins A, Nash M, Lynch AM. Antidepressant-associated sexual dysfunction: Impact, effects, and treatment. Drug Healthc Patient Saf 2010;2:141-150.
11. Pfaus JG, Kippin TE, Coria-Avila G. What can animal models tell us about human sexual response? Annu Rev Sex Res 2003;14:1-63.
12. Modell JG, Katholi CR, Modell JD, DePalma RL. Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther 1997;61:476-487.
13. Uphouse L, Guptarak J. Serotonin and sexual behavior. In: Müller C, Jacobs B, eds. Handbook of behavioral neurobiology of serotonin. Amsterdam: Elsevier; 2010:347-365.
14. Moll JL, Brown CS. The use of monoamine pharmacological agents in the treatment of sexual dysfunction: Evidence in the literature. J Sex Med 2011;8:956-970.
15. Hueletl-Soto ME, Carro-Juárez M, Rodríguez-Manzo G. Fluoxetine chronic treatment inhibits male rat sexual behavior by affecting both copulatory behavior and the genital motor pattern of ejaculation. J Sex Med 2012;9:1015-1026.
16. Vega Matuszczyk V, Larsson K, Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 1998;60:527-532.
17. Matuszczyk JV, Larsson K, Eriksson E. Subchronic administration of fluoxetine impairs estrous behavior in intact female rats. Neuropsychopharmacology 1998;19:492-498.
18. Adams S, Heckard D, Hassell J, Uphouse L. Factors influencing fluoxetine-induced sexual dysfunction in female rats. Behav Brain Res 2012;235:73-81.
19. Sarkar J, Hiegel C, Ginis GE, Hilbun E, Uphouse L. Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior. Brain Res 2008;1190:56-64.
20. Uphouse L, Hensler JG, Sarkar J, Grossie B. Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. Brain Res 2006;1072:79-90.
21. Maswood N, Sarkar J, Uphouse L. Modest effects of repeated fluoxetine on estrous cyclicity and sexual behavior in Sprague Dawley female rats. Brain Res 2008;1245:52-60.
22. Sarkar J, Hiegel C, Maswood N, Uphouse L. Daily male exposure attenuates estrous cycle disruption by fluoxetine. Behav Brain Res 2008;189:83-91.
23. Segraves RT, Clayton A, Croft H, Wolf A, Warnock J. Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. J Clin Psychopharmacol 2004;24:339-342.
24. López HH, Wurzel G, Ragen B. The effect of acute bupropion on sexual motivation and behavior in the female rat. Pharmacol Biochem Behav 2007;87:369-379.
25. Tam SW, Worcel M, Wyllie M. Yohimbine: A clinical review. Pharmacol Ther 2001;91:215-243.
26. Sala M, Braida D, Leone MP, Calcaterra P, Monti S, Gori E. Central effect of yohimbine on sexual behavior in the rat. Physiol Behav 1990;47:165-173.
27. Tallentire D, McRae G, Spedding M, Clark R, Vickery B. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol 1996;118:63-72.
28. Rodríguez-Manzo G, Fernández-Guasti A. Participation of the central noradrenergic system in the reestablishment of copulatory behavior of sexually exhausted rats by yohimbine, naloxone, and 8-OH-DPAT. Brain Res Bull 1995;38:399-404.
29. Viitamaa T, Haapalinna A, Ågmo A. The adrenergic α2 receptor and sexual incentive motivation in male rats. Pharmacol Biochem Behav 2006;83:360-369.
30. Clark JT, Smith ER, Davidson JM. Enhancement of sexual motivation in male rats by yohimbine. Science 1984;225:847-849.
31. Rampin O. Pharmacology of alpha-adrenoceptors in male sexual function. Eur Urol 1999;36(1 suppl):103-106.
32. Estrada-Camarena E, Rivera NM, Berlanga C, Fernández-Guasti A. Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test. Psychopharmacology (Berl) 2008;201:351-360.
33. Santamaría A, Arias HR. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behav Brain Res 2010;211:132-139.
34. Davis GA, Kohl R. The influence of alpha-receptors on lordosis in the female rat. Pharmacol Biochem Behav 1977;6:47-53.
35. Laws and Codes of Mexico. Seventh Title of the Regulations of the General Law of Health regarding Health Research. 12th edition. Mexico: Porrúa Publishers; 1995.
36. Goldman JM, Murr AS, Cooper RL. The rodent estrous cycle: Characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res B Dev Reprod Toxicol 2007;80:84-97.
37. Coopersmith C, Candurra C, Erskine MS. Effects of paced mating and intromissive stimulation on feminine sexual behavior and estrus termination in the cycling rat. J Comp Psychol 1996;110:176-186.
38. Hardy DF, DeBold JF. Effects of coital stimulation upon behavior of the female rat. J Comp Physiol Psychol 1972;78:400-408.
39. Paredes RG, Ågmo A. Has dopamine a physiological role in the control of sexual behavior? A critical review of the evidence. Prog Neurobiol 2004;73:179-226.
40. Berridge KC, Robinson TE. What is the role of dopamine in reward? Hedonic impact, reward learning, or incentive salience? Brain Res 1998;28:309-369.
41. Ågmo A. An incentive motivational framework and the description of sexual behaviors. In: Functional and dysfunctional sexual behavior: A synthesis of neuroscience and comparative psychology. San Diego: Academic Press; 2007:30-76.
42. Graham MD, Pfaus JG. Differential regulation of female sexual behaviour by dopamine agonists in the medial preoptic area. Pharmacol Biochem Behav 2010;97:284-292.
43. Rodríguez-Manzo G. Yohimbine interacts with the dopaminergic system to reverse sexual satiation: Further evidence for a role of sexual motivation in sexual exhaustion. Eur J Pharmacol 1999;372:1-8.
44. Koyama Y, Fujita I, Aou S, Oomura Y. Proceptive presenting elicited by electrical stimulation of the female monkey hypothalamus. Brain Res 1988;446:199-203.
45. Floody OR. Time course of VMN lesion effects on lordosis and proceptive behavior in female hamsters. Horm Behav 2002;41:366-376.
46. Ogawa S, Olazábal UE, Parhar IS, Pfaff DW. Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat. J Neurosci 1994;14:1766-1774.
47. Ågmo A. Neural control of sexual behavior. In: Functional and dysfunctional sexual behavior: A synthesis of neuroscience and comparative psychology. San Diego.: Academic Press; 2007:231-256.
48. Fernández-Guasti A, Larsson K, Beyer C. Potentiative action of alpha- and beta-adrenergic receptor stimulation in inducing lordosis behavior. Pharmacol Biochem Behav 1985;22:613-617.
49. Etgen AM. Intrahypothalamic implants of noradrenergic antagonists disrupt lordosis behavior in female rats. Physiol Behav 1990;48:31-36.
50. Malik KF, Morrell JI, Feder HH. Effects of alpha-2-adrenergic drugs in the medial preoptic area and medial basal hypothalamus on lordosis in the guinea pig. Brain Res 1993;628:26-30.
51. Chopin P, Pellow S, File SE. The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not at benzodiazepine receptors. Neuropharmacology 1986;25:53-57.
52. Bowes MP, Peters RH, Kernan WJ Jr, Hopper DL. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol Biochem Behav 1992;41:707-713.
53. Gelez H, Greggain-Mohr J, Pfaus JG, Allers KA, Giuliano F. Flibanserin treatment increases appetitive sexual motivation in the female rat. J Sex Med 2013;10:1231-1239.
54. Pfaus J, Giuliano F, Gelez H. Bremelanotide: An overview of preclinical CNS effects on female sexual function. J Sex Med 2007;4:269-279.
55. Snoeren EM, Chan JS, de Jong TR, Waldinger MD, Olivier B, Oosting RS. A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence. J Sex Med 2011;8:44-56.