Yohimbine interacts with the dopaminergic system to reverse sexual satiation: Further evidence for a role of sexual motivation in sexual exhaustion

European Journal of Pharmacology

Volumn 372, Issue 1, 1999, Pages 1-8

  Rodríguez Manzo, Gabriela ^a,b  

^a Secc de Terap Experimental   (Mexico)

^b Div de Invest en Neurociencias   (Mexico)

Author keywords

Dopamine noradrenaline interaction; Sexual behavior, male rat; Sexual exhaustion; Sexual motivation; Yohimbine

Indexed keywords

APOMORPHINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; YOHIMBINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COPULATION; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; EJACULATION; EXHAUSTION; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SATIETY; SEXUAL BEHAVIOR;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; APOMORPHINE; COPULATION; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EJACULATION; FEMALE; HALOPERIDOL; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SATIETY RESPONSE; SEXUAL BEHAVIOR, ANIMAL; WALKING; YOHIMBINE;

EID: 0344780707     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00140-5     Document Type: Article

References (44)

1. Andén N.E., Grabowska M. Pharmacological evidence for a stimulation of dopamine neurones by noradrenaline neurones in the brain. Eur. J. Pharmacol. 39:1976;275-282.
2. Andén N.E., Strömbom U. Adrenergic receptor blocking agents: effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia. 38:1974;91-103.
3. Andén N.E., Pauksens K., Svensson K. Selective blockade of brain alpha 2-autoreceptors by yohimbine: effects on motor activity and on turnover of noradrenaline and dopamine. J. Neural Transm. 55:1982;111-120.
4. Beach F.A., Jordan L. Sexual exhaustion and recovery in the male rat. Q. J. Exp. Psychol. 8:1956;121-133.
5. Benelli A., Arletti R., Basaglia R., Bertolini A. Male sexual behaviour: further studies on the role of alpha 2-adrenoceptors. Pharmacol. Res. 28:1993;35-45.
6. Berridge C.W., Stratford T.L., Foote S.L., Kelley A.E. Distribution of dopamine beta-hydroxylase-like immunoreactive fibres within the shell subregion of the nucleus accumbens. Synapse. 27:1997;230-241.
7. Bitran D., Hull E.M., Holmes G.M., Lookingland K.J. Regulation of male copulatory behaviour by preoptic incertohypothalamic dopamine neurones. Brain Res. Bull. 20:1988;323-331.
8. Clark J.T., Smith E., Davidson J.M. Enhancement of sexual motivation in male rats by yohimbine. Science. 225:1984;847-849.
9. Clark J.T., Smith E., Davidson J.M. Evidence for the modulation of sexual behaviour by α-adrenoceptors in male rats. Neuroendocrinology. 41:1985;36-43.
10. Damsma G., Pfaus J.G., Wenkstern D., Phillips A.G., Fibiger H.C. Sexual behaviour increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav. Neurosci. 106:1992;181-191.
11. 2 receptor agonist-induced behavioural effects in rats. Eur. J. Pharmacol. 250:1993;51-57.
12. Fiorino D.F., Coury A., Phillips A.G. Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats. J. Neurosci. 17:1997;4849-4855.
13. Gresch P.J., Sved A.F., Zigmond M.J., Finlay J.M. Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex. J. Neurochem. 65:1995;111-116.
14. 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;570-582.
15. Hull E.M., Du J., Lorrain D.S., Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J. Neurosci. 15:1995;7465-7471.
16. Hull E.M., Du J., Lorrain D.S., Matuszewich L. Testosterone, preoptic dopamine and copulation in male rats. Brain Res. Bull. 44:1997;327-333.
17. Johnston A.L., File S.E. Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites. Pharmacol. Biochem. Behav. 32:1989;151-156.
18. Larsson, K., 1956. Conditioning and Sexual Behaviour in the Male Albino Rat. Almqvist and Wiksell, Stockholm.
19. Lawrence K., Barfield R. Differential rates of exhaustion and recovery of several parameters of male rat sexual behaviour. J. Comp. Physiol. Psychol. 8:1975;693-703.
20. Le Moal, M., 1995. Mesocorticolimbic dopaminergic neurones. Functional and regulatory roles. In: Bloom, F.E., Kupfer, D.J. (Eds.), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, NY, pp. 283-294.
21. Maeda T., Kitahama K., Geffard M. Dopaminergic innervation of rat locus coeruleus: a light and electron microscopic immunohistochemical study. Microsc. Res. Tech. 29:1994;211-218.
22. Mas M., González-Mora J.G., Louilot A., Solé A., Guadalupe T. Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltammetry. Neurosci. Lett. 110:1990;303-308.
23. Mas M., Fumero B., Fernández-Vera J.R., González-Mora J.L. Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdyalisis. Brain Res. 675:1995;13-19.
24. Mas M., Fumero B., Pérez-Rodríguez I. Induction of mating behaviour by apomorphine in sexually sated rats. Eur. J. Pharmacol. 280:1995;331-334.
25. Mitchell, J.B., Gratton, A., 1994. Involvement of mesolimbic dopamine neurones in sexual behaviours: implications for the neurobiology of motivation.
26. Pfaus J.G., Gorzalka B.B. Opioids and sexual behaviour. Neurosci. Biobehav. Rev. 11:1987;1-34.
27. Pfaus J.G., Mendelson S.D., Phillips A.G. A correlational and factor analysis of anticipatory and consummatory measures of sexual behaviour in the male rat. Psychoneuroendocrinology. 15:1990;329-340.
28. Pfaus J.G., Damsma G., Nomikos G.G., Wenkstern D.G., Blaha C.D., Phillips A.G., Fibiger H.C. Sexual behaviour enhances central dopamine transmission in the male rat. Brain Res. 530:1990;345-348.
29. Pleim E.T., Matochik J.A., Barfield R.J., Auerbach S.B. Correlation of dopamine release in the nucleus accumbens with masculine sexual behaviour in rats. Brain Res. 524:1990;160-163.
30. Pycock C. Noradrenergic involvement in dopamine-dependent stereotyped and cataleptic responses in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 298:1977;15-22.
31. Rodríguez-Manzo, G., 1999. Blockade of the establishment of the sexual inhibition resulting from sexual exhaustion by the Coolidge effect. Behav. Brain Res. (in press).
32. Rodríguez-Manzo G., Fernández-Guasti A. Reversal of sexual exhaustion by serotonergic and noradrenergic agents. Behav. Brain Res. 62:1994;127-134.
33. Rodríguez-Manzo G., Fernández-Guasti A. Opioid antagonists and the sexual satiation phenomenon. Psychopharmacology (Berlin). 122:1995;131-136.
34. Rodríguez-Manzo G., Fernández-Guasti A. Participation of the central noradrenergic system in the re-establishment of copulatory behaviour of sexually exhausted rats by yohimbine, naloxone and 8-OH-DPAT. Brain Res. Bull. 38:1995;399-404.
35. Salamone J.D. The behavioural neurochemistry of motivation: methodological and conceptual issues in studies of the dynamic activity of nucleus accumbens dopamine. J. Neurosci. Methods. 64:1996;137-149.
36. Sato Y., Wada H., Horita H., Suzuki N., Shibuya A., Adachi H., Kato R., Tsukamoto T., Kumamoto Y. Dopamine release in the medial preoptic area during male copulatory behaviour in rats. Brain Res. 692:1995;66-70.
37. Scaletta L.L., Hull E.M. Systemic or intracranial apomorphine increases copulation in long-term castrated male rats. Pharmacol. Biochem. Behav. 37:1990;471-475.
38. Scatton B., Zivkovic B., Dedek J. Antidopaminergic properties of yohimbine. J. Pharmacol. Exp. Ther. 215:1980;494-499.
39. Siegel, S., 1965. Nonparametric Statistics for the Behavioural Sciences. McGraw Hill, New York, NY.
40. 2-adrenoceptor antagonists and male sexual behaviour: I. Mating behaviour. Physiol. Behav. 41:1987;7-14.
41. Steel, R.G.D., Torrie, J.H., 1985. Principles and Procedures of Statistics. A Biometrical Approach. McGraw Hill, New York, NY.
42. Van Furth W.R., Wolterink G., Van Ree J.M. Regulation of masculine sexual behaviour: involvement of brain opioids and dopamine. Brain Res. Rev. 21:1995;162-184.
43. Wenkstern D., Pfaus J.G., Fibiger H.C. Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats. Brain Res. 618:1993;41-46.
44. 2 adrenoceptor antagonist or a selective dopamine uptake inhibitor: evidence for dopamine release from local dopaminergic nerve terminals. J. Pharmacol. Exp. Ther. 267:1993;211-217.