The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

EMBO Reports

Volumn 14, Issue 11, 2013, Pages 975-983

  Garvin, Alexander J ^a   Densham, Ruth M ^a   Blair Reid, Sarah A ^a   Pratt, Kenny M ^a   Stone, Helen R ^a   Weekes, Daniel ^b   Lawrence, Kirsty J ^a   Morris, Joanna R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

homologous recombination; HP1a; KAP1; SENP7; SUMO

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1 ALPHA; KRAB ASSOCIATED PROTEIN 1; PEPTIDASE; PROTEIN; SENP7 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; RECOMBINATION REPAIR; SUMOYLATION;

MAMMALIA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA HELICASES; ENDOPEPTIDASES; HEK293 CELLS; HELA CELLS; HUMANS; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINATIONAL DNA REPAIR; SUMO-1 PROTEIN;

EID: 84887038983     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.141     Document Type: Article

References (28)

1. Psakhye I, Jentsch S (2012) Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell 151: 807-820
2. Bekker-Jensen S, Mailand N (2011) The ubiquitin-and SUMO-dependent signaling response to DNA double-strand breaks. FEBS Lett 585: 2914-2919
3. Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (2009) Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell 34: 145-154
4. Ivanov AV et al (2007) PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol Cell 28: 823-837
5. Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway. Nat Cell Biol 8: 870-876
6. Goodarzi AA, Kurka T, Jeggo PA (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol 18: 831-839
7. Goodarzi AA, Noon AT, Jeggo PA (2009) The impact of heterochromatin on DSB repair. Biochem Soc Trans 37: 569-576
8. Hickey CM, Wilson NR, Hochstrasser M (2012) Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol 13: 755-766
9. Schulz S et al (2012) Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. Embo Rep 13: 930-938
10. Shin EJ, Shin HM, Nam E, Kim WS, Kim JH, Oh BH, Yun Y (2012) DeSUMOylating isopeptidase: a second class of SUMO protease. Embo Rep 13: 339-346
11. Shen LN, Geoffroy MC, Jaffray EG, Hay RT (2009) Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J 421: 223-230
12. Lima CD, Reverter D (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem 283: 32045-32055
13. Jiang M, Chiu SY, Hsu W (2011) SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ 18: 1005-1015
14. Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S (2011) NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell 43: 180-191
15. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET (2010) Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell 39: 333-345
16. Nozawa RS, Nagao K, Masuda HT, Iwasaki O, Hirota T, Nozaki N, Kimura H, Obuse C (2010) Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol 12: 719-727
17. Maison C, Romeo K, Bailly D, Dubarry M, Quivy JP, Almouzni G (2012) The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Nat Struct Mol Biol 19: 458-460
18. Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET (2012) Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci USA 109: 17466-17471
19. Bekes M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS (2011) The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem 286: 10238-10247
20. Alegre KO, Reverter D (2011) Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7. J Biol Chem 286: 36142-36151
21. Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH (2011) Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144: 732-744
22. Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y (2012) The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol 199: 1067-1081
23. White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd (2006) KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res 66: 11594-11599
24. Bruderer R, Tatham MH, Plechanovova A, Matic I, Garg AK, Hay RT (2011) Purification and identification of endogenous polySUMO conjugates. Embo Rep 12: 142-148
25. Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT (2009) System-wide changes to SUMO modifications in response to heat shock. Sci Signal 2: ra24
26. Bowen NJ, Fujita N, Kajita M, Wade PA (2004) Mi-2/NuRD: multiple complexes for many purposes. Biochimica et biophysica acta 1677: 52-57
27. Iyengar S, Farnham PJ (2011) KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem 286: 26267-26276
28. Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR (2012) The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J 31: 3918-3934