Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 43, 2012, Pages 17466-17471

  Bawa Khalfe, Tasneem ^a   Lu, Long Sheng ^b   Zuo, Yong ^c   Huang, Chao ^b   Dere, Ruhee ^d   Lin, Feng Ming ^b   Yeh, Edward T H ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b ST LUKE S EPISCOPAL HOSPITAL   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Dedifferentiation; Epigenetics; Posttranslational modification

Indexed keywords

ENZYME VARIANT; HETEROCHROMATIN PROTEIN 1; PEPTIDASE; PROTEINASE; SUMO PROTEIN; SUMO SPECIFIC PROTEASE 7; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL AGING; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; RNA SPLICING; SUMOYLATION; TUMOR GROWTH;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; ENDOPEPTIDASES; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; HUMANS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84867910575     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209378109     Document Type: Article

References (24)

1. Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET (2010) SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem 285:25859-25866.
2. Bawa-Khalfe T, Yeh ET (2010) SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression. Genes Cancer 1:748-752.
3. Yeh ET, Gong L, Kamitani T (2000) Ubiquitin-like proteins: New wines in new bottles. Gene 248:1-14. (Pubitemid 30259196)
4. Alegre KO, Reverter D (2011) Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7. J Biol Chem 286:36142-36151.
5. Lima CD, Reverter D (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem 283:32045-32055.
6. Maison C, et al. (2012) The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Nat Struct Mol Biol 19:458-460.
7. Kang X, et al. (2010) SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell 38:191-201.
8. Maison C, et al. (2011) SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin. Nat Genet 43:220-227.
9. Shin JA, et al. (2005) SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Mol Cell 19:817-828. (Pubitemid 41316675)
10. Norwood LE, et al. (2006) A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion. J Biol Chem 281:18668-18676. (Pubitemid 44035527)
11. De Koning L, et al. (2009) Heterochromatin protein 1alpha: A hallmark of cell proliferation relevant to clinical oncology. EMBO Mol Med 1:178-191.
12. Kirschmann DA, et al. (2000) Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer. Cancer Res 60:3359-3363. (Pubitemid 30482146)
13. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428.
14. Narita M, et al. (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113:703-716. (Pubitemid 36724935)
15. Panteleeva I, et al. (2007) HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J 26:3616-3628. (Pubitemid 47236874)
16. Rastogi S, et al. (2006) Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol 26:4161-4171. (Pubitemid 43788018)
17. Hu J, et al. (2011) Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun 411:786-791.
18. Guan F, Handa K, Hakomori SI (2009) Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. Proc Natl Acad Sci USA 106:7461-7466.
19. Nielsen SJ, et al. (2001) Rb targets histone H3 methylation and HP1 to promoters. Nature 412:561-565. (Pubitemid 32743837)
20. Maehara K, et al. (2005) Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53. J Cell Biol 168:553-560. (Pubitemid 40271020)
21. Ansieau S, et al. (2008) Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14:79-89. (Pubitemid 351890463)
22. Liu Y, El-Naggar S, Darling DS, Higashi Y, Dean DC (2008) Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 135:579-588.
23. Kokura K, Sun L, Bedford MT, Fang J (2010) Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J 29:3673-3687.
24. Sánchez-Tilló E, et al. (2010) ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene 29:3490-3500.